DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Dendrid (Idoxuridine Ophthalmic) - Description and Clinical Pharmacology

 
 



DENDRID®
(idoxuridine)
Sterile Ophthalmic Solution

DESCRIPTION

Dendrid® (idoxuridine) is an antiviral chemotherapeutic agent prepared in a sterile buffered isotonic solution. The active ingredient is represented by the chemical structure:

Established name:

Idoxuridine

Chemical name:

Uridine, 2’-deoxy-5-iodo-

Each ml contains: Active: Idoxuridine 0.1%. Preservative: Benzalkonium Chloride 0.01%. Inactive: Boric Acid, Edetate Disodium, Sodium Hydroxide and/or Hydrochloric Acid (to adjust pH), Purified Water. DM-01

CLINICAL PHARMACOLOGY

Herpes simplex virus utilizes thymidine in the synthesis of deoxyribonucleic acid (DNA), a metabolite necessary for reproduction. Idoxuridine is identical in chemical structure to thymidine except that the 5-methyl group is replaced by iodine. When idoxuridine is substituted for thymidine in DNA, the cell is unable to utilize the DNA and reproduction ceases.

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017