Meperidine hydrochloride is ethyl 1-methyl-4-phenylisonipecotate hydrochloride, a white crystalline substance with a melting point of 186°C to 189°C. It is readily soluble in water and has a neutral reaction and a slightly bitter taste. The solution is not decomposed by a short period of boiling.
DEMEROL injectable is supplied in Carpuject with luer lock of 2.5% (25 mg/1 mL), 5% (50 mg/1 mL), 7.5% (75 mg/1 mL), and 10% (100 mg/1 mL). Uni-Amp unit dose pak-ampuls of 5% solution (25 mg/0.5 mL), (50 mg/1 mL), (75 mg/1.5 mL), (100 mg/2 mL), and 10% solution (100 mg/1 mL). Multiple-dose vials of 5% and 10% solutions contain metacresol 0.1% as preservative.
The pH of DEMEROL solutions is adjusted between 3.5 and 6 with sodium hydroxide or hydrochloric acid.
DEMEROL, brand of meperidine hydrochloride, 5 percent solution has a specific gravity of 1.0086 at 20°C and 10 percent solution, a specific gravity of 1.0165 at 20°C.
DEMEROL (MEPERIDINE) is indicated for the following:
For the relief of moderate to severe pain
For preoperative medication
support of anesthesia
For obstetrical analgesia
Media Articles Related to Demerol (Meperidine)
Chest pain: New tool helps doctors decide when tests are needed
Source: Cardiovascular / Cardiology News From Medical News Today [2017.02.17]
A two year follow-up on a study involving more than 10,000 people with stable chest pain finds that an online tool can accurately predict which patients are likely to have normal non-invasive tests...
Survey Data Paint Picture of PCMH Docs
Source: MedPage Today Public Health & Policy [2017.02.17]
(MedPage Today) -- More support staff, better access to patients' medical records
Spinal Manipulation for Back and Neck Pain: Does It Work?
Source: Medscape Anesthesiology Headlines [2017.02.15]
For decades, osteopathic physicians and chiropractors, who sought to relieve patients' back and neck pain with spinal manipulation, were accused of being quacks. But mounting evidence supports it.
New Reports Paint Mixed Picture of State Telemedicine Laws
Source: Medscape Business of Medicine Headlines [2017.02.14]
State laws increasingly support telemedicine, but change has been slow; all 50 state Medicaid programs now cover virtual visits.
Medscape Medical News
New clinical guideline issued for treating low back pain
Source: Clinical Trials / Drug Trials News From Medical News Today [2017.02.14]
The American College of Physicians have just issued their clinical practice guideline for the noninvasive treatment of nonradicular low back pain.
Published Studies Related to Demerol (Meperidine)
Meperidine relieves pain during transrectal ultrasound-guided prostate biopsy. 
ultrasound-guided prostate biopsy... CONCLUSION: Intramuscular meperidine injection is a safe and effective analgesic
Intra-articular bupivacaine reduces postoperative pain and meperidine use after
total hip arthroplasty: a randomized, double-blind study. 
One hundred patients receiving unilateral total hip arthroplasty (THA) were
randomized to receive an intra-articular injection of 300mg bupivacaine or normal
saline after completion of surgery. Pain scores of the bupivacaine group were
significantly lower than those of the control group the first 12hours
postoperatively (all, P<0.001).
Comparison of the analgesic efficacy of dexketoprofen trometamol and meperidine
HCl in the relief of renal colic. 
In this study, the analgesic effects of dexketoprofen trometamol and meperidine
hydrochloride were compared in patients diagnosed with renal colic. This study
was a prospective, randomized, double-blind study... With this
study, we concluded that dexketoprofen trometamol, from the nonsteroidal
anti-inflammatory drug group, can be within the primary treatment options for
renal colic because of better analgesic efficacy, being well tolerated by
patients compared with meperidine hydrochloride.
Meperidine for uterine dystocia and its effect on duration of labor and neonatal
acid-base status: a randomized clinical trial. 
CONCLUSION: Because of the absence of any beneficial effect of meperidine on
Antishivering effects of two different doses of intrathecal meperidine in caesarean section: a prospective randomised blinded study. [2011.03]
BACKGROUND AND OBJECTIVE: Shivering causes various adverse disturbances and interferes with monitoring. The optimal dose of intrathecal meperidine to prevent shivering without producing other side-effects remains unknown. This prospective randomised double-blinded study was conducted to compare the antishivering effects of two different doses of intrathecal meperidine... CONCLUSION: The use of intrathecal meperidine for caesarean section during spinal anaesthesia for the prevention of shivering cannot be recommended as its use is associated with increased incidence of nausea and vomiting.
Clinical Trials Related to Demerol (Meperidine)
Remifentanil Only vs. Midazolam and Meperidine During Elective Colonoscopy [Completed]
A Comparison of Meperidine for Post-Cesarean Analgesia: Bolus Versus Infusion and Bolus [Not yet recruiting]
The purpose of this study is to determine if epidural meperidine administered by
patient-controlled bolus button is equivalent to a low dose infusion plus patient-controlled
Efficacy and Safety Profiles of Combination Sedation Propofol With Midazolam and Meperidine. [Completed]
The purpose of this study is to compare efficacy and safety of combination of propofol and
midazolam with meperidine versus midazolam and meperidine for ambulatory ERCP
Neuraxial Pethidine After Lumbar Surgery Trial [Recruiting]
The hypothesis is that epidural pethidine is an effective form of pain relief following
lumbar spinal surgery, resulting in significantly lower usage of concomitantly administered
(intravenous) patient-controlled analgesia (PCA) pethidine.
Study of the Effectiveness of Administration of Meperidine on the Length of Active Phase of Labor in Women [Recruiting]
Labor pain is universal and occurs acutely. This is the most painful experience in a woman's
life. Pain relief during labor is expected to have positive impact on the progress, outcome
and cost of labor. However, it is controversial whether labor analgesia shortens the length
of labor and influences progression to cesarean. Labor analgesia can be performed via spinal,
epidural or systemic routes (intravenous or intramuscular). Opioid agonists (meperidine,
fentanyl etc.) as well are the systemic agents frequently used for labor analgesia. Results
of the studies concerning effect of meperidine on the length of labor are controversial.
Many studies have expressed that meperidine has no effect or effect on the progress of
labor. This study aims to evaluate the effect of meperidine on the length of active phase of
labor in nulliparous or multiparous women, who will be randomized into case and control
Reports of Suspected Demerol (Meperidine) Side Effects
Drug Hypersensitivity (63),
Abdominal Pain (7),
Confusional State (6),
Clostridium Difficile Colitis (6),
Pneumonia Fungal (6),
Febrile Neutropenia (6),
Leukaemia Recurrent (5), more >>