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Demerol (Meperidine Hydrochloride) - Summary

 
 



DEMEROL SUMMARY

Meperidine hydrochloride is a narcotic analgesic with multiple actions qualitatively similar to those of morphine; the most prominent of these involve the central nervous system and organs composed of smooth muscle. The principal actions of therapeutic value are analgesia and sedation.

DEMEROL is indicated for the relief of moderate to severe pain.

DEMEROL contains meperidine, a mu-agonist opioid with an abuse liability similar to morphine and is a Schedule II controlled substance. Meperidine, like morphine and other opioids used in analgesia, can be abused and is subject to criminal diversion.
See all Demerol indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Demerol (Meperidine)

Many U.S. Workers on Disability Use Narcotic Painkillers, Study Finds
Source: MedicineNet Chronic Pain Specialty [2014.08.22]
Title: Many U.S. Workers on Disability Use Narcotic Painkillers, Study Finds
Category: Health News
Created: 8/22/2014 9:36:00 AM
Last Editorial Review: 8/22/2014 12:00:00 AM

U.S. to Tighten Access to Certain Narcotic Painkillers
Source: MedicineNet Drug Abuse Specialty [2014.08.22]
Title: U.S. to Tighten Access to Certain Narcotic Painkillers
Category: Health News
Created: 8/21/2014 4:36:00 PM
Last Editorial Review: 8/22/2014 12:00:00 AM

Treating pain by blocking the 'chili-pepper receptor'
Source: Biology / Biochemistry News From Medical News Today [2014.08.21]
Biting into a chili pepper causes a burning spiciness that is irresistible to some, but intolerable to others.

IBS - why pain relief drugs don't work
Source: GastroIntestinal / Gastroenterology News From Medical News Today [2014.08.21]
New research from the University of Adelaide is the first in the world to explain why people with irritable bowel syndrome - also known as IBS - may not get relief from pain medications.

After brachial plexus injury, electroacupuncture attenuates neuropathic pain
Source: Medical Devices / Diagnostics News From Medical News Today [2014.08.21]
Electroacupuncture has traditionally been used to treat pain, but its effect on pain following brachial plexus injury is still unknown.

more news >>

Published Studies Related to Demerol (Meperidine)

Meperidine for uterine dystocia and its effect on duration of labor and neonatal acid-base status: a randomized clinical trial. [2012]
CONCLUSION: Because of the absence of any beneficial effect of meperidine on

Antishivering effects of two different doses of intrathecal meperidine in caesarean section: a prospective randomised blinded study. [2011.03]
BACKGROUND AND OBJECTIVE: Shivering causes various adverse disturbances and interferes with monitoring. The optimal dose of intrathecal meperidine to prevent shivering without producing other side-effects remains unknown. This prospective randomised double-blinded study was conducted to compare the antishivering effects of two different doses of intrathecal meperidine... CONCLUSION: The use of intrathecal meperidine for caesarean section during spinal anaesthesia for the prevention of shivering cannot be recommended as its use is associated with increased incidence of nausea and vomiting.

Ondansetron and meperidine prevent postoperative shivering after general anesthesia. [2011.02]
BACKGROUND: Postoperative shivering is one of the common problems following general anesthesia and may lead to multiple complications. The aim of this study was to examine the preventive effects of Ondansetron and Meperidine on postoperative shivering... CONCLUSION: Ondansetron can effectively reduce post operative shivering.

Preemptive peritonsillar ketamine infiltration: postoperative analgesic efficacy versus meperidine. [2011.02]
OBJECTIVES: The current study was planned to assess post-tonsillectomy analgesic efficacy of pre-emptive peritonsillar ketamine infiltration with or without bupivacaine in comparison to meperidine alone or in combination with bupivacaine... CONCLUSION: Peritonsillar injection of a combination of bupivacaine and ketamine provided efficient postoperative analgesia after adenotonsillectomy and achieved higher parents' satisfaction for the outcome of surgery. The used drugs' combination and volume could be recommended as a routine preemptive analgesic policy for children assigned for adenotonsillectomy.

Ondansetron and meperidine prevent postoperative shivering after general anesthesia. [2011]
postoperative shivering... CONCLUSION: Ondansetron can effectively reduce post operative shivering.

more studies >>

Clinical Trials Related to Demerol (Meperidine)

Remifentanil Only vs. Midazolam and Meperidine During Elective Colonoscopy [Recruiting]
The aim of the present study is to compare patients discharge time from the recovery unit between remifentanil only group and combination group (midazolam + meperidine) during elective colonoscopy

A Comparison of Meperidine for Post-Cesarean Analgesia: Bolus Versus Infusion and Bolus [Not yet recruiting]
The purpose of this study is to determine if epidural meperidine administered by patient-controlled bolus button is equivalent to a low dose infusion plus patient-controlled bolus.

Neuraxial Pethidine After Lumbar Surgery Trial [Recruiting]
The hypothesis is that epidural pethidine is an effective form of pain relief following lumbar spinal surgery, resulting in significantly lower usage of concomitantly administered (intravenous) patient-controlled analgesia (PCA) pethidine.

Study of the Effectiveness of Administration of Meperidine on the Length of Active Phase of Labor in Women [Recruiting]
Labor pain is universal and occurs acutely. This is the most painful experience in a woman's life. Pain relief during labor is expected to have positive impact on the progress, outcome and cost of labor. However, it is controversial whether labor analgesia shortens the length of labor and influences progression to cesarean. Labor analgesia can be performed via spinal, epidural or systemic routes (intravenous or intramuscular). Opioid agonists (meperidine, fentanyl etc.) as well are the systemic agents frequently used for labor analgesia. Results of the studies concerning effect of meperidine on the length of labor are controversial.

Many studies have expressed that meperidine has no effect or effect on the progress of labor. This study aims to evaluate the effect of meperidine on the length of active phase of labor in nulliparous or multiparous women, who will be randomized into case and control groups.

Study to Determine if the Midazolam-Meperidine-Dexmedetomidine is Superior to the Midazolam-Meperidine for Sedation During ERCP [Recruiting]
Endoscopic retrograde cholangiopancreatography (ERCP) takes a longer time and is more complex to perform than the other parallel procedures, causing discomfort to patients. It is commonly performed under sedation endoscopy. Until recently, the combination administration of midazolam and opioid has been widely used as standard therapy due to its superior sedation effect compared to the other sedation agents. Midazolam, however, has problems, such as an insufficient sedation effect and an intermittent paradoxical response.

Unlike midazolam, propofol has no antagonist and may cause problems such as respiratory depression, and has a narrow therapeutic range for the sedation effect, consequently requiring supervision by experienced experts, although it has a better sedation effect than midazolam. Due to these disadvantages, propofol is clinically less useful than midazolam.

Meanwhile, dexmedetomidine, a selective α2 adrenergic agonist, is known to maintain the proper level of sedation and has a weak influence on respiratory depression. Recent studies have shown positive results with dexmedetomidine in relation with the sedation effect for surgery patients under local anesthesia or in intensive care units.

As such, extensive studies are being conducted on the use of dexmedetomidine in endoscopic procedures due to the increased attention to dexmedetomidine. This notwithstanding, the clinical usefulness of dexmedetomidine is still debatable. In particular, studies on the use of dexmedetomidine for ERCP are very rare.

Given the recent idea that dexmedetomidine may exert a synergistic effect in combination with midazolam, these authors endeavored to prospectively compare and analyze the sedation effect and adverse events, including respiratory depression, of the combination therapy of midazolam and meperidine, both of which have been widely used in patients undergoing ERCP, and of the combination therapy of midazolam, meperidine, and dexmedetomidine.

The small-scale comparative study on the combination administration of propofol and fentanyl, which has a high risk of causing complications, and on the single administration of dexmedetomidine is the only study on the sedation effect of dexmedetomidine in the ERCP procedure that has yet been conducted; there has been no study that investigated the effect of the combination administration of dexmedetomidine and other drugs in the ERCP procedure. This study is thus expected to contribute to the development of guidelines on sedation in the ERCP procedure.

more trials >>

Reports of Suspected Demerol (Meperidine) Side Effects

Drug Hypersensitivity (63)Vomiting (11)Nausea (11)Abdominal Pain (7)Dyskinesia (7)Confusional State (6)Clostridium Difficile Colitis (6)Pneumonia Fungal (6)Febrile Neutropenia (6)Leukaemia Recurrent (5)more >>


Page last updated: 2014-08-22

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