DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Demerol (Meperidine Hydrochloride) - Summary



Meperidine hydrochloride is a narcotic analgesic with multiple actions qualitatively similar to those of morphine; the most prominent of these involve the central nervous system and organs composed of smooth muscle. The principal actions of therapeutic value are analgesia and sedation.

DEMEROL is indicated for the relief of moderate to severe pain.

DEMEROL contains meperidine, a mu-agonist opioid with an abuse liability similar to morphine and is a Schedule II controlled substance. Meperidine, like morphine and other opioids used in analgesia, can be abused and is subject to criminal diversion.
See all Demerol indications & dosage >>


Media Articles Related to Demerol (Meperidine)

One in 3 women could potentially be spared chronic pain after breast cancer surgery
Source: Breast Cancer News From Medical News Today [2015.02.28]
One in every three women undergoing a mastectomy could potentially be spared chronic post-operative pain if anesthesiologists used a regional anesthetic technique in combination with standard care...

Work-Related Pain Common Among Staff in Cath Labs
Source: theheart.org | Medscape Cardiology Headlines [2015.02.26]
More than half of personnel working in the interventional lab experience some sort of work-related musculoskeletal pain, report investigators. Many of these individuals even sought medical care for their injuries.

Low-Risk Chest Pain Controversy: The FOAMed Report
Source: MedPage Today Emergency Medicine [2015.02.26]
(MedPage Today) -- Sore throats, terrorists, and how to keep up with all that literature,

Health Tip: Avoid Overdosing on Pain Medication
Source: MedicineNet Chronic Pain Specialty [2015.02.25]
Title: Health Tip: Avoid Overdosing on Pain Medication
Category: Health News
Created: 2/25/2015 12:00:00 AM
Last Editorial Review: 2/25/2015 12:00:00 AM

Certain Painkillers Ill-Advised After Heart Attack: Study
Source: MedicineNet Heart Attack Specialty [2015.02.25]
Title: Certain Painkillers Ill-Advised After Heart Attack: Study
Category: Health News
Created: 2/24/2015 12:00:00 AM
Last Editorial Review: 2/25/2015 12:00:00 AM

more news >>

Published Studies Related to Demerol (Meperidine)

Meperidine for uterine dystocia and its effect on duration of labor and neonatal acid-base status: a randomized clinical trial. [2012]
CONCLUSION: Because of the absence of any beneficial effect of meperidine on

Antishivering effects of two different doses of intrathecal meperidine in caesarean section: a prospective randomised blinded study. [2011.03]
BACKGROUND AND OBJECTIVE: Shivering causes various adverse disturbances and interferes with monitoring. The optimal dose of intrathecal meperidine to prevent shivering without producing other side-effects remains unknown. This prospective randomised double-blinded study was conducted to compare the antishivering effects of two different doses of intrathecal meperidine... CONCLUSION: The use of intrathecal meperidine for caesarean section during spinal anaesthesia for the prevention of shivering cannot be recommended as its use is associated with increased incidence of nausea and vomiting.

Ondansetron and meperidine prevent postoperative shivering after general anesthesia. [2011.02]
BACKGROUND: Postoperative shivering is one of the common problems following general anesthesia and may lead to multiple complications. The aim of this study was to examine the preventive effects of Ondansetron and Meperidine on postoperative shivering... CONCLUSION: Ondansetron can effectively reduce post operative shivering.

Preemptive peritonsillar ketamine infiltration: postoperative analgesic efficacy versus meperidine. [2011.02]
OBJECTIVES: The current study was planned to assess post-tonsillectomy analgesic efficacy of pre-emptive peritonsillar ketamine infiltration with or without bupivacaine in comparison to meperidine alone or in combination with bupivacaine... CONCLUSION: Peritonsillar injection of a combination of bupivacaine and ketamine provided efficient postoperative analgesia after adenotonsillectomy and achieved higher parents' satisfaction for the outcome of surgery. The used drugs' combination and volume could be recommended as a routine preemptive analgesic policy for children assigned for adenotonsillectomy.

Ondansetron and meperidine prevent postoperative shivering after general anesthesia. [2011]
postoperative shivering... CONCLUSION: Ondansetron can effectively reduce post operative shivering.

more studies >>

Clinical Trials Related to Demerol (Meperidine)

Remifentanil Only vs. Midazolam and Meperidine During Elective Colonoscopy [Recruiting]
The aim of the present study is to compare patients discharge time from the recovery unit between remifentanil only group and combination group (midazolam + meperidine) during elective colonoscopy

Study to Determine if the Midazolam-Meperidine-Dexmedetomidine is Superior to the Midazolam-Meperidine for Sedation During ERCP [Recruiting]
Endoscopic retrograde cholangiopancreatography (ERCP) takes a longer time and is more complex to perform than the other parallel procedures, causing discomfort to patients. It is commonly performed under sedation endoscopy. Until recently, the combination administration of midazolam and opioid has been widely used as standard therapy due to its superior sedation effect compared to the other sedation agents. Midazolam, however, has problems, such as an insufficient sedation effect and an intermittent paradoxical response.

Unlike midazolam, propofol has no antagonist and may cause problems such as respiratory depression, and has a narrow therapeutic range for the sedation effect, consequently requiring supervision by experienced experts, although it has a better sedation effect than midazolam. Due to these disadvantages, propofol is clinically less useful than midazolam.

Meanwhile, dexmedetomidine, a selective α2 adrenergic agonist, is known to maintain the proper level of sedation and has a weak influence on respiratory depression. Recent studies have shown positive results with dexmedetomidine in relation with the sedation effect for surgery patients under local anesthesia or in intensive care units.

As such, extensive studies are being conducted on the use of dexmedetomidine in endoscopic procedures due to the increased attention to dexmedetomidine. This notwithstanding, the clinical usefulness of dexmedetomidine is still debatable. In particular, studies on the use of dexmedetomidine for ERCP are very rare.

Given the recent idea that dexmedetomidine may exert a synergistic effect in combination with midazolam, these authors endeavored to prospectively compare and analyze the sedation effect and adverse events, including respiratory depression, of the combination therapy of midazolam and meperidine, both of which have been widely used in patients undergoing ERCP, and of the combination therapy of midazolam, meperidine, and dexmedetomidine.

The small-scale comparative study on the combination administration of propofol and fentanyl, which has a high risk of causing complications, and on the single administration of dexmedetomidine is the only study on the sedation effect of dexmedetomidine in the ERCP procedure that has yet been conducted; there has been no study that investigated the effect of the combination administration of dexmedetomidine and other drugs in the ERCP procedure. This study is thus expected to contribute to the development of guidelines on sedation in the ERCP procedure.

Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction [Completed]
This study involves approximately 200 patients designed to evaluate the efficacy and safety of intranasal (IN) morphine 7. 5 mg and 15 mg, intravenous morphine (IV) 7. 5 mg, immediate release oral (PO) morphine 60 mg or placebo in patients with acute postsurgical pain following third molar extraction.

Comparison of A Single Dose Combination of Methadone and Morphine With Morphine Alone for Treating Post-Operative Pain [Recruiting]

Efficacy and Safety of Intranasal Morphine for Pain After Bunion Surgery [Completed]
Study designed to evaluate the efficacy and safety of Intranasal (IN) Morphine Nasal Spray (MNS075) 3. 75 mg, 7. 5 mg, 15 mg, and 30 mg, intravenous (IV) morphine 7. 5 mg, or IN placebo in patients with moderate to severe post-surgical pain following orthopedic surgery. After initial dosing, up to six (6) doses of IN MNS075 7. 5 mg or 15 mg for up to twenty-four (24) hours will be evaluated. The rescue dose remained the same for each.

more trials >>

Reports of Suspected Demerol (Meperidine) Side Effects

Drug Hypersensitivity (63)Vomiting (11)Nausea (11)Abdominal Pain (7)Dyskinesia (7)Confusional State (6)Clostridium Difficile Colitis (6)Pneumonia Fungal (6)Febrile Neutropenia (6)Leukaemia Recurrent (5)more >>

Page last updated: 2015-02-28

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2015