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Demerol (Meperidine Hydrochloride) - Summary



Meperidine hydrochloride is ethyl 1-methyl-4-phenylisonipecotate hydrochloride, a white crystalline substance with a melting point of 186°C to 189°C. It is readily soluble in water and has a neutral reaction and a slightly bitter taste. The solution is not decomposed by a short period of boiling. DEMEROL injectable is supplied in Carpuject™ with luer lock of 2.5% (25 mg/1 mL), 5% (50 mg/1 mL), 7.5% (75 mg/1 mL), and 10% (100 mg/1 mL). Uni-Amp™ unit dose pak-ampuls of 5% solution (25 mg/0.5 mL), (50 mg/1 mL), (75 mg/1.5 mL), (100 mg/2 mL), and 10% solution (100 mg/1 mL). Multiple-dose vials of 5% and 10% solutions contain metacresol 0.1% as preservative. The pH of DEMEROL solutions is adjusted between 3.5 and 6 with sodium hydroxide or hydrochloric acid. DEMEROL, brand of meperidine hydrochloride, 5 percent solution has a specific gravity of 1.0086 at 20°C and 10 percent solution, a specific gravity of 1.0165 at 20°C.

DEMEROL (MEPERIDINE) is indicated for the following:

For the relief of moderate to severe pain

For preoperative medication

For support of anesthesia

For obstetrical analgesia

See all Demerol indications & dosage >>


Media Articles Related to Demerol (Meperidine)

Newly Insured Treasure Medicaid, But Growing Pains Felt
Source: Medscape Medical News Headlines [2015.10.02]
The Affordable Care Act unleashed a building boom of community health centers across the country. At a cost of $11 billion, more than 950 health centers have opened and thousands have expanded or modernized.
Kaiser Health News

Pneumothorax treatment gets less painful
Source: Respiratory / Asthma News From Medical News Today [2015.10.02]
Scientists working in Tianjin Chest Hospital, China, have developed a less painful treatment strategy for Pneumothorax treatment.

Menopausal women experiencing distressing pain during sex
Source: Psychology / Psychiatry News From Medical News Today [2015.10.01]
Results from qualitative research of postmenopausal women with vulvar and vaginal atrophy (VVA) show that they recognize the significant physical, emotional and psychological consequences of...

Canadian multicentre study examines safety of medical cannabis in the treatment of chronic pain
Source: Alcohol / Addiction / Illegal Drugs News From Medical News Today [2015.09.30]
A Canadian research team led by Dr. Mark Ware from the Research Institute of the McGill University Health Centre (RI-MUHC) in Montréal has completed a national multicentre study looking at the...

New drug trial could help relieve the pain of diabetes
Source: Clinical Trials / Drug Trials News From Medical News Today [2015.09.25]
UK patients with diabetic neuropathy are being recruited for a phase II clinical trial which will evaluate the safety, tolerability and efficacy of a novel class of analgesicThe trial will be...

more news >>

Published Studies Related to Demerol (Meperidine)

Meperidine relieves pain during transrectal ultrasound-guided prostate biopsy. [2014]
ultrasound-guided prostate biopsy... CONCLUSION: Intramuscular meperidine injection is a safe and effective analgesic

Intra-articular bupivacaine reduces postoperative pain and meperidine use after total hip arthroplasty: a randomized, double-blind study. [2014]
One hundred patients receiving unilateral total hip arthroplasty (THA) were randomized to receive an intra-articular injection of 300mg bupivacaine or normal saline after completion of surgery. Pain scores of the bupivacaine group were significantly lower than those of the control group the first 12hours postoperatively (all, P<0.001).

Comparison of the analgesic efficacy of dexketoprofen trometamol and meperidine HCl in the relief of renal colic. [2014]
In this study, the analgesic effects of dexketoprofen trometamol and meperidine hydrochloride were compared in patients diagnosed with renal colic. This study was a prospective, randomized, double-blind study... With this study, we concluded that dexketoprofen trometamol, from the nonsteroidal anti-inflammatory drug group, can be within the primary treatment options for renal colic because of better analgesic efficacy, being well tolerated by patients compared with meperidine hydrochloride.

Meperidine for uterine dystocia and its effect on duration of labor and neonatal acid-base status: a randomized clinical trial. [2012]
CONCLUSION: Because of the absence of any beneficial effect of meperidine on

Antishivering effects of two different doses of intrathecal meperidine in caesarean section: a prospective randomised blinded study. [2011.03]
BACKGROUND AND OBJECTIVE: Shivering causes various adverse disturbances and interferes with monitoring. The optimal dose of intrathecal meperidine to prevent shivering without producing other side-effects remains unknown. This prospective randomised double-blinded study was conducted to compare the antishivering effects of two different doses of intrathecal meperidine... CONCLUSION: The use of intrathecal meperidine for caesarean section during spinal anaesthesia for the prevention of shivering cannot be recommended as its use is associated with increased incidence of nausea and vomiting.

more studies >>

Clinical Trials Related to Demerol (Meperidine)

Remifentanil Only vs. Midazolam and Meperidine During Elective Colonoscopy [Completed]

A Comparison of Meperidine for Post-Cesarean Analgesia: Bolus Versus Infusion and Bolus [Not yet recruiting]
The purpose of this study is to determine if epidural meperidine administered by patient-controlled bolus button is equivalent to a low dose infusion plus patient-controlled bolus.

Efficacy and Safety Profiles of Combination Sedation Propofol With Midazolam and Meperidine. [Completed]
The purpose of this study is to compare efficacy and safety of combination of propofol and midazolam with meperidine versus midazolam and meperidine for ambulatory ERCP

Neuraxial Pethidine After Lumbar Surgery Trial [Recruiting]
The hypothesis is that epidural pethidine is an effective form of pain relief following lumbar spinal surgery, resulting in significantly lower usage of concomitantly administered (intravenous) patient-controlled analgesia (PCA) pethidine.

Study of the Effectiveness of Administration of Meperidine on the Length of Active Phase of Labor in Women [Recruiting]
Labor pain is universal and occurs acutely. This is the most painful experience in a woman's life. Pain relief during labor is expected to have positive impact on the progress, outcome and cost of labor. However, it is controversial whether labor analgesia shortens the length of labor and influences progression to cesarean. Labor analgesia can be performed via spinal, epidural or systemic routes (intravenous or intramuscular). Opioid agonists (meperidine, fentanyl etc.) as well are the systemic agents frequently used for labor analgesia. Results of the studies concerning effect of meperidine on the length of labor are controversial. Many studies have expressed that meperidine has no effect or effect on the progress of labor. This study aims to evaluate the effect of meperidine on the length of active phase of labor in nulliparous or multiparous women, who will be randomized into case and control groups.

more trials >>

Reports of Suspected Demerol (Meperidine) Side Effects

Drug Hypersensitivity (63)Vomiting (11)Nausea (11)Abdominal Pain (7)Dyskinesia (7)Confusional State (6)Clostridium Difficile Colitis (6)Pneumonia Fungal (6)Febrile Neutropenia (6)Leukaemia Recurrent (5)more >>

Page last updated: 2015-10-02

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