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Demerol (Meperidine Hydrochloride) - Summary

 
 



DEMEROL SUMMARY

Meperidine hydrochloride is ethyl 1-methyl-4-phenylisonipecotate hydrochloride, a white crystalline substance with a melting point of 186°C to 189°C. It is readily soluble in water and has a neutral reaction and a slightly bitter taste. The solution is not decomposed by a short period of boiling. DEMEROL injectable is supplied in Carpuject™ with luer lock of 2.5% (25 mg/1 mL), 5% (50 mg/1 mL), 7.5% (75 mg/1 mL), and 10% (100 mg/1 mL). Uni-Amp™ unit dose pak-ampuls of 5% solution (25 mg/0.5 mL), (50 mg/1 mL), (75 mg/1.5 mL), (100 mg/2 mL), and 10% solution (100 mg/1 mL). Multiple-dose vials of 5% and 10% solutions contain metacresol 0.1% as preservative. The pH of DEMEROL solutions is adjusted between 3.5 and 6 with sodium hydroxide or hydrochloric acid. DEMEROL, brand of meperidine hydrochloride, 5 percent solution has a specific gravity of 1.0086 at 20°C and 10 percent solution, a specific gravity of 1.0165 at 20°C.

DEMEROL (MEPERIDINE) is indicated for the following:

For the relief of moderate to severe pain

For preoperative medication

For support of anesthesia

For obstetrical analgesia


See all Demerol indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Demerol (Meperidine)

Medical News Today: Complex regional pain syndrome: Watching others causes pain
Source: Featured Health News from Medical News Today [2016.12.02]
For patients with complex regional pain syndrome, simply watching someone else move can cause intense pain. An MRI scan study delves into the neuroscience.

Complex regional pain syndrome: Watching others causes pain
Source: Pain / Anesthetics News From Medical News Today [2016.12.02]
For patients with complex regional pain syndrome, simply watching someone else move can cause intense pain. An MRI scan study delves into the neuroscience.

Specially Designed Video Game Might Ease 'Phantom Limb' Pain
Source: MedicineNet Chronic Pain Specialty [2016.12.02]
Title: Specially Designed Video Game Might Ease 'Phantom Limb' Pain
Category: Health News
Created: 12/1/2016 12:00:00 AM
Last Editorial Review: 12/2/2016 12:00:00 AM

Should Pain Scores No Longer Be Vital?
Source: Medscape Anesthesiology Headlines [2016.12.01]
Asking patients how severe their pain is on a scale of 1 to 10 isn't vital to pain management, the AAFP says. What do you think?
Medscape Reader Polls

Can VR Games Soothe Phantom Limb Pain?
Source: MedPage Today Neurology [2016.12.01]
(MedPage Today) -- Pain reduced among arm amputees

more news >>

Published Studies Related to Demerol (Meperidine)

Meperidine relieves pain during transrectal ultrasound-guided prostate biopsy. [2014]
ultrasound-guided prostate biopsy... CONCLUSION: Intramuscular meperidine injection is a safe and effective analgesic

Intra-articular bupivacaine reduces postoperative pain and meperidine use after total hip arthroplasty: a randomized, double-blind study. [2014]
One hundred patients receiving unilateral total hip arthroplasty (THA) were randomized to receive an intra-articular injection of 300mg bupivacaine or normal saline after completion of surgery. Pain scores of the bupivacaine group were significantly lower than those of the control group the first 12hours postoperatively (all, P<0.001).

Comparison of the analgesic efficacy of dexketoprofen trometamol and meperidine HCl in the relief of renal colic. [2014]
In this study, the analgesic effects of dexketoprofen trometamol and meperidine hydrochloride were compared in patients diagnosed with renal colic. This study was a prospective, randomized, double-blind study... With this study, we concluded that dexketoprofen trometamol, from the nonsteroidal anti-inflammatory drug group, can be within the primary treatment options for renal colic because of better analgesic efficacy, being well tolerated by patients compared with meperidine hydrochloride.

Meperidine for uterine dystocia and its effect on duration of labor and neonatal acid-base status: a randomized clinical trial. [2012]
CONCLUSION: Because of the absence of any beneficial effect of meperidine on

Antishivering effects of two different doses of intrathecal meperidine in caesarean section: a prospective randomised blinded study. [2011.03]
BACKGROUND AND OBJECTIVE: Shivering causes various adverse disturbances and interferes with monitoring. The optimal dose of intrathecal meperidine to prevent shivering without producing other side-effects remains unknown. This prospective randomised double-blinded study was conducted to compare the antishivering effects of two different doses of intrathecal meperidine... CONCLUSION: The use of intrathecal meperidine for caesarean section during spinal anaesthesia for the prevention of shivering cannot be recommended as its use is associated with increased incidence of nausea and vomiting.

more studies >>

Clinical Trials Related to Demerol (Meperidine)

Remifentanil Only vs. Midazolam and Meperidine During Elective Colonoscopy [Completed]

A Comparison of Meperidine for Post-Cesarean Analgesia: Bolus Versus Infusion and Bolus [Not yet recruiting]
The purpose of this study is to determine if epidural meperidine administered by patient-controlled bolus button is equivalent to a low dose infusion plus patient-controlled bolus.

Efficacy and Safety Profiles of Combination Sedation Propofol With Midazolam and Meperidine. [Completed]
The purpose of this study is to compare efficacy and safety of combination of propofol and midazolam with meperidine versus midazolam and meperidine for ambulatory ERCP

Neuraxial Pethidine After Lumbar Surgery Trial [Recruiting]
The hypothesis is that epidural pethidine is an effective form of pain relief following lumbar spinal surgery, resulting in significantly lower usage of concomitantly administered (intravenous) patient-controlled analgesia (PCA) pethidine.

Study of the Effectiveness of Administration of Meperidine on the Length of Active Phase of Labor in Women [Recruiting]
Labor pain is universal and occurs acutely. This is the most painful experience in a woman's life. Pain relief during labor is expected to have positive impact on the progress, outcome and cost of labor. However, it is controversial whether labor analgesia shortens the length of labor and influences progression to cesarean. Labor analgesia can be performed via spinal, epidural or systemic routes (intravenous or intramuscular). Opioid agonists (meperidine, fentanyl etc.) as well are the systemic agents frequently used for labor analgesia. Results of the studies concerning effect of meperidine on the length of labor are controversial. Many studies have expressed that meperidine has no effect or effect on the progress of labor. This study aims to evaluate the effect of meperidine on the length of active phase of labor in nulliparous or multiparous women, who will be randomized into case and control groups.

more trials >>

Reports of Suspected Demerol (Meperidine) Side Effects

Drug Hypersensitivity (63)Vomiting (11)Nausea (11)Abdominal Pain (7)Dyskinesia (7)Confusional State (6)Clostridium Difficile Colitis (6)Pneumonia Fungal (6)Febrile Neutropenia (6)Leukaemia Recurrent (5)more >>


Page last updated: 2016-12-02

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