Published Studies Related to Demerol Injection (Meperidine)
Meperidine for uterine dystocia and its effect on duration of labor and neonatal
acid-base status: a randomized clinical trial. 
CONCLUSION: Because of the absence of any beneficial effect of meperidine on
Antishivering effects of two different doses of intrathecal meperidine in caesarean section: a prospective randomised blinded study. [2011.03]
BACKGROUND AND OBJECTIVE: Shivering causes various adverse disturbances and interferes with monitoring. The optimal dose of intrathecal meperidine to prevent shivering without producing other side-effects remains unknown. This prospective randomised double-blinded study was conducted to compare the antishivering effects of two different doses of intrathecal meperidine... CONCLUSION: The use of intrathecal meperidine for caesarean section during spinal anaesthesia for the prevention of shivering cannot be recommended as its use is associated with increased incidence of nausea and vomiting.
Preemptive peritonsillar ketamine infiltration: postoperative analgesic efficacy versus meperidine. [2011.02]
OBJECTIVES: The current study was planned to assess post-tonsillectomy analgesic efficacy of pre-emptive peritonsillar ketamine infiltration with or without bupivacaine in comparison to meperidine alone or in combination with bupivacaine... CONCLUSION: Peritonsillar injection of a combination of bupivacaine and ketamine provided efficient postoperative analgesia after adenotonsillectomy and achieved higher parents' satisfaction for the outcome of surgery. The used drugs' combination and volume could be recommended as a routine preemptive analgesic policy for children assigned for adenotonsillectomy.
Ondansetron and meperidine prevent postoperative shivering after general anesthesia. [2011.02]
BACKGROUND: Postoperative shivering is one of the common problems following general anesthesia and may lead to multiple complications. The aim of this study was to examine the preventive effects of Ondansetron and Meperidine on postoperative shivering... CONCLUSION: Ondansetron can effectively reduce post operative shivering.
Ondansetron and meperidine prevent postoperative shivering after general
postoperative shivering... CONCLUSION: Ondansetron can effectively reduce post operative shivering.
Clinical Trials Related to Demerol Injection (Meperidine)
Remifentanil Only vs. Midazolam and Meperidine During Elective Colonoscopy [Recruiting]
The aim of the present study is to compare patients discharge time from the recovery unit
between remifentanil only group and combination group (midazolam + meperidine) during
A Comparison of Meperidine for Post-Cesarean Analgesia: Bolus Versus Infusion and Bolus [Not yet recruiting]
The purpose of this study is to determine if epidural meperidine administered by
patient-controlled bolus button is equivalent to a low dose infusion plus patient-controlled
Neuraxial Pethidine After Lumbar Surgery Trial [Recruiting]
The hypothesis is that epidural pethidine is an effective form of pain relief following
lumbar spinal surgery, resulting in significantly lower usage of concomitantly administered
(intravenous) patient-controlled analgesia (PCA) pethidine.
Study of the Effectiveness of Administration of Meperidine on the Length of Active Phase of Labor in Women [Recruiting]
Labor pain is universal and occurs acutely. This is the most painful experience in a woman's
life. Pain relief during labor is expected to have positive impact on the progress, outcome
and cost of labor. However, it is controversial whether labor analgesia shortens the length
of labor and influences progression to cesarean. Labor analgesia can be performed via spinal,
epidural or systemic routes (intravenous or intramuscular). Opioid agonists (meperidine,
fentanyl etc.) as well are the systemic agents frequently used for labor analgesia. Results
of the studies concerning effect of meperidine on the length of labor are controversial.
Many studies have expressed that meperidine has no effect or effect on the progress of
labor. This study aims to evaluate the effect of meperidine on the length of active phase of
labor in nulliparous or multiparous women, who will be randomized into case and control
Study to Determine if the Midazolam-Meperidine-Dexmedetomidine is Superior to the Midazolam-Meperidine for Sedation During ERCP [Recruiting]
Endoscopic retrograde cholangiopancreatography (ERCP) takes a longer time and is more
complex to perform than the other parallel procedures, causing discomfort to patients. It is
commonly performed under sedation endoscopy. Until recently, the combination administration
of midazolam and opioid has been widely used as standard therapy due to its superior
sedation effect compared to the other sedation agents. Midazolam, however, has problems,
such as an insufficient sedation effect and an intermittent paradoxical response.
Unlike midazolam, propofol has no antagonist and may cause problems such as respiratory
depression, and has a narrow therapeutic range for the sedation effect, consequently
requiring supervision by experienced experts, although it has a better sedation effect than
midazolam. Due to these disadvantages, propofol is clinically less useful than midazolam.
Meanwhile, dexmedetomidine, a selective α2 adrenergic agonist, is known to maintain the
proper level of sedation and has a weak influence on respiratory depression. Recent studies
have shown positive results with dexmedetomidine in relation with the sedation effect for
surgery patients under local anesthesia or in intensive care units.
As such, extensive studies are being conducted on the use of dexmedetomidine in endoscopic
procedures due to the increased attention to dexmedetomidine. This notwithstanding, the
clinical usefulness of dexmedetomidine is still debatable. In particular, studies on the use
of dexmedetomidine for ERCP are very rare.
Given the recent idea that dexmedetomidine may exert a synergistic effect in combination
with midazolam, these authors endeavored to prospectively compare and analyze the sedation
effect and adverse events, including respiratory depression, of the combination therapy of
midazolam and meperidine, both of which have been widely used in patients undergoing ERCP,
and of the combination therapy of midazolam, meperidine, and dexmedetomidine.
The small-scale comparative study on the combination administration of propofol and
fentanyl, which has a high risk of causing complications, and on the single administration
of dexmedetomidine is the only study on the sedation effect of dexmedetomidine in the ERCP
procedure that has yet been conducted; there has been no study that investigated the effect
of the combination administration of dexmedetomidine and other drugs in the ERCP procedure.
This study is thus expected to contribute to the development of guidelines on sedation in
the ERCP procedure.