DRUG INTERACTIONS
The pharmacokinetic interactions listed below are potentially clinically important. Drugs that induce hepatic enzymes such as phenobarbital, phenytoin and rifampin may increase the clearance of corticosteroids and may require increases in corticosteroid dose to achieve the desired response. Drugs such as troleandomycin and ketoconazole may inhibit the metabolism of corticosteroids and thus decrease their clearance. Therefore, the dose of corticosteroid should be titrated to avoid steroid toxicity. Corticosteroids may increase the clearance of chronic high dose aspirin. This could lead to decreased salicylate serum levels or increase the risk of salicylate toxicity when corticosteroid is withdrawn. Aspirin should be used cautiously in conjunction with corticosteroids in patients suffering from hypoprothrombinemia. The effect of corticosteroids on oral anticoagulants is variable. There are reports of enhanced as well as diminished effects of anticoagulants when given concurrently with corticosteroids. Therefore, coagulation indices should be monitored to maintain the desired anticoagulant effect.
|
REFERENCES
-
Fekety R. Infections associated with corticosteroids and immunosuppressive therapy. In: Gorbach SL, Bartlett JG, Blacklow NR, eds. Infectious Diseases. Philadelphia: WBSaunders Company 1992:1050-1.
-
Stuck AE, Minder CE, Frey FJ. Risk of infectious complications in patients taking glucocorticoids. Rev Infect Dis 1989:11(6):954-63.
Pharmacia & Upjohn Company
A subsidiary of Pharmacia Corporation
Kalamazoo, Michigan 49001, USA
Revised April 2002
DRUG INTERACTIONS
The pharmacokinetic interactions listed below are potentially clinically important. Drugs that induce hepatic enzymes such as phenobarbital, phenytoin and rifampin may increase the clearance of corticosteroids and may require increases in corticosteroid dose to achieve the desired response. Drugs such as troleandomycin and ketoconazole may inhibit the metabolism of corticosteroids and thus decrease their clearance. Therefore, the dose of corticosteroid should be titrated to avoid steroid toxicity. Corticosteroids may increase the clearance of chronic high dose aspirin. This could lead to decreased salicylate serum levels or increase the risk of salicylate toxicity when corticosteroid is withdrawn. Aspirin should be used cautiously in conjunction with corticosteroids in patients suffering from hypoprothrombinemia. The effect of corticosteroids on oral anticoagulants is variable. There are reports of enhanced as well as diminished effects of anticoagulants when given concurrently with corticosteroids. Therefore, coagulation indices should be monitored to maintain the desired anticoagulant effect.
OTHER INFORMATION
FOREIGN BRAND AVAILABILITY:
- Canada, New Zealand - Apo-Prednisone
- France - Cortancyl
- Germany - Cutason
- Spain - Dacorten
- Bulgaria, Germany - Decortin
- England, Ireland, Philippines - Decortisyl
- Denmark - Delcortin
- Indonesia - Dellacort A
- Italy - Deltacortene
- Japan - Deltacortone
- Sweden - Deltison
- Argentina - Deltisona
- Japan - Di-Adreson
- Philippines - Drazone
- Poland - Encorton
- Indonesia - Hostacortin
- Finland - Me-Korti
- Peru - Nisona
- Australia, South Africa - Panafcort
- Indonesia - Pehacort
- Germany - Prednicorm
- Belgium - Prednicort
- Mexico - Prednidib
- Israel - Prednitone
- South Africa - Pulmison
- Australia - Sone
- Philippines - Steerometz
- Germany - Ultracorten
- Canada - Winpred
|
