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Deltasone (Prednisone) - Description and Clinical Pharmacology



Deltasone tablets contain prednisone which is a glucocorticoid. Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract. Prednisone is a white to practically white, odorless, crystalline powder. It is very slightly soluble in water; slightly soluble in alcohol, in chloroform, in dioxane, and in methanol.
The chemical name for prednisone is pregna-1,4-diene-3,11,20-trione,17,21-dihydroxy- and its molecular weight is 358.43.

The structural formula of prednisone is:

Deltasone are available in 5 strengths: 2.5, 5, 10, 20, and 50 mg. Inactive Ingredients: 2.5 mg:Calcium stearate, corn starch, erythrosine sodium, lactose, mineral oil, sorbic acid and sucrose. 5 mg:Calcium stearate, corn starch, lactose, mineral oil, sorbic acid and sucrose. 10 mg:Calcium stearate, corn starch, lactose, sorbic acid and sucrose. 20 mg:Calcium stearate, corn starch, FD&C yellow no. 6, lactose, sorbic acid and sucrose.50 mg:Corn starch, lactose, magnesium stearate, sorbic acid, sucrose, and talc.


Naturally occurring glucocorticoids (hydrocortisone and cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs are primarily used for their potent anti-inflammatory effects in disorders of many organ systems.

Glucocorticoids cause profound and varied metabolic effects. In addition, they modify the body's immune responses to diverse stimuli.

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