ADVERSE REACTIONS (listed alphabetically, under each subsection)
The following adverse reactions have been reported with DECADRON or other corticosteroids:
Allergic reactions: Anaphylactoid reaction, anaphylaxis, angioedema.
Cardiovascular: Bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, fat embolism, hypertension, hypertrophic cardiomyopathy in premature infants, myocardial rupture following recent myocardial infarction (see WARNINGS, Cardio-renal), edema, pulmonary edema, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis.
Dermatologic: Acne, allergic dermatitis, dry scaly skin, ecchymoses and petechiae, erythema, impaired wound healing, increased sweating, rash, striae, suppression of reactions to skin tests, thin fragile skin, thinning scalp hair, urticaria.
Endocrine: Decreased carbohydrate and glucose tolerance, development of cushingoid state, hyperglycemia, glycosuria, hirsutism, hypertrichosis, increased requirements for insulin or oral hypoglycemic agents in diabetes, manifestations of latent diabetes mellitus, menstrual irregularities, secondary adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery, or illness), suppression of growth in pediatric patients.
Fluid and electrolyte disturbances: Congestive heart failure in susceptible patients, fluid retention, hypokalemic alkalosis, potassium loss, sodium retention.
Gastrointestinal: Abdominal distention, elevation in serum liver enzyme levels (usually reversible upon discontinuation), hepatomegaly, increased appetite, nausea, pancreatitis, peptic ulcer with possible perforation and hemorrhage, perforation of the small and large intestine (particularly in patients with inflammatory bowel disease), ulcerative esophagitis.
Metabolic: Negative nitrogen balance due to protein catabolism.
Musculoskeletal: Aseptic necrosis of femoral and humeral heads, loss of muscle mass, muscle weakness, osteoporosis, pathologic fracture of long bones, steroid myopathy, tendon rupture, vertebral compression fractures.
Neurological/Psychiatric: Convulsions, depression, emotional instability, euphoria, headache, increased intracranial pressure with papilledema (pseudotumor cerebri) usually following discontinuation of treatment, insomnia, mood swings, neuritis, neuropathy, paresthesia, personality changes, psychic disorders, vertigo.
Ophthalmic: Exophthalmos, glaucoma, increased intraocular pressure, posterior subcapsular cataracts.
Other: Abnormal fat deposits, decreased resistance to infection, hiccups, increased or decreased motility and number of spermatozoa, malaise, moon face, weight gain.
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REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO DECADRON
Below is a sample of reports where side effects / adverse reactions may be related to Decadron. The information is not vetted and should not be cosidered as verified clinical evidence.
Possible Decadron side effects / adverse reactions in 93 year old female
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2007-01-08
Patient: 93 year old female
Reactions: Melaena
Suspect drug(s):
Decadron
Administration route: Oral
Start date: 2006-08-31
End date: 2006-09-03
Enoxaparin Sodium
Indication: Immobile
Start date: 2006-08-29
End date: 2006-09-02
Other drugs received by patient: Adalat; Amoxicillin + Clavulanate Potassium; Metronidazole; Trazodone Hydrochloride
Possible Decadron side effects / adverse reactions in 86 year old male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2007-01-09
Patient: 86 year old male
Reactions: Haematuria
Adverse event resulted in: hospitalization
Suspect drug(s):
Decadron
Administration route: Oral
Start date: 2006-08-29
End date: 2006-08-31
Aspirin
Administration route: Oral
Indication: Prophylaxis
Start date: 2006-08-17
Enoxaparin Sodium
Start date: 2006-08-16
End date: 2006-09-01
Clopidogrel Bisulfate
Administration route: Oral
Indication: Prophylaxis
Start date: 2006-08-17
Other drugs received by patient: Bisoprolol; Furosemide; Isosorbide Mononitrate; Metronidazole
Possible Decadron side effects / adverse reactions in 51 year old male
Reported by a physician from United States on 2007-01-11
Patient: 51 year old male
Reactions: Pneumonia, Coagulopathy, International Normalised Ratio Increased, Disease Progression, Loss of Consciousness
Adverse event resulted in: hospitalization
Suspect drug(s):
Thalomid
Dosage: 100 mg, 1 in 1 d, oral; 50 mg, 1 in 1 d, oral
Administration route: Oral
Indication: Multiple Myeloma
Start date: 2005-06-01
End date: 2005-07-01
Thalomid
Dosage: 100 mg, 1 in 1 d, oral; 50 mg, 1 in 1 d, oral
Administration route: Oral
Indication: Multiple Myeloma
Start date: 2005-07-13
End date: 2005-08-01
Thalomid
Decadron
Indication: Drug USE FOR Unknown Indication
Other drugs received by patient: Coumadin (Warfarin Sodium)q
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