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Decadron (Dexamethasone) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS (listed alphabetically, under each subsection)

The following adverse reactions have been reported with DECADRON or other corticosteroids:

Allergic reactions: Anaphylactoid reaction, anaphylaxis, angioedema.

Cardiovascular: Bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, fat embolism, hypertension, hypertrophic cardiomyopathy in premature infants, myocardial rupture following recent myocardial infarction (see WARNINGS, Cardio-renal), edema, pulmonary edema, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis.

Dermatologic: Acne, allergic dermatitis, dry scaly skin, ecchymoses and petechiae, erythema, impaired wound healing, increased sweating, rash, striae, suppression of reactions to skin tests, thin fragile skin, thinning scalp hair, urticaria.

Endocrine: Decreased carbohydrate and glucose tolerance, development of cushingoid state, hyperglycemia, glycosuria, hirsutism, hypertrichosis, increased requirements for insulin or oral hypoglycemic agents in diabetes, manifestations of latent diabetes mellitus, menstrual irregularities, secondary adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery, or illness), suppression of growth in pediatric patients.

Fluid and electrolyte disturbances: Congestive heart failure in susceptible patients, fluid retention, hypokalemic alkalosis, potassium loss, sodium retention.

Gastrointestinal: Abdominal distention, elevation in serum liver enzyme levels (usually reversible upon discontinuation), hepatomegaly, increased appetite, nausea, pancreatitis, peptic ulcer with possible perforation and hemorrhage, perforation of the small and large intestine (particularly in patients with inflammatory bowel disease), ulcerative esophagitis.

Metabolic: Negative nitrogen balance due to protein catabolism.

Musculoskeletal: Aseptic necrosis of femoral and humeral heads, loss of muscle mass, muscle weakness, osteoporosis, pathologic fracture of long bones, steroid myopathy, tendon rupture, vertebral compression fractures.

Neurological/Psychiatric: Convulsions, depression, emotional instability, euphoria, headache, increased intracranial pressure with papilledema (pseudotumor cerebri) usually following discontinuation of treatment, insomnia, mood swings, neuritis, neuropathy, paresthesia, personality changes, psychic disorders, vertigo.

Ophthalmic: Exophthalmos, glaucoma, increased intraocular pressure, posterior subcapsular cataracts.

Other: Abnormal fat deposits, decreased resistance to infection, hiccups, increased or decreased motility and number of spermatozoa, malaise, moon face, weight gain.



REPORTS OF SUSPECTED DECADRON SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Decadron. The information is not vetted and should not be considered as verified clinical evidence.

Possible Decadron side effects / adverse reactions in 51 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2011-10-04

Patient: 51 year old female

Reactions: Pancreatitis Acute, Chills, Hyperhidrosis, Pallor, Pancreatitis Necrotising, Glomerulonephritis, Obesity, Chest Pain, Gastrooesophageal Reflux Disease, Renal Failure Acute, Refusal of Treatment by Patient, Type 2 Diabetes Mellitus, Blood Triglycerides Decreased, Hyponatraemia, Haemodialysis, Heart Rate Decreased, Skin Neoplasm Excision, Hypertension, Sleep Apnoea Syndrome, Influenza Like Illness

Adverse event resulted in: hospitalization, disablity

Suspect drug(s):
Intron A
    Dosage: iv; iv
    Indication: Malignant Melanoma Stage III
    Start date: 2011-03-28
    End date: 2011-04-01

Intron A
    Dosage: iv; iv
    Indication: Malignant Melanoma Stage III
    Start date: 2011-03-21
    End date: 2011-03-25

Decadron

Other drugs received by patient: Compazine; Hydrochlorothiazide; Aspirin; Percocet; Norvasc



Possible Decadron side effects / adverse reactions in 66 year old male

Reported by a physician from Japan on 2011-10-06

Patient: 66 year old male

Reactions: Type 2 Diabetes Mellitus, Pneumatosis Intestinalis

Adverse event resulted in: hospitalization

Suspect drug(s):
Decadron
    Administration route: Oral
    Indication: Prostate Cancer

Basen
    Administration route: Oral
    Indication: Type 2 Diabetes Mellitus
    Start date: 2010-09-01

Other drugs received by patient: Taxol; Actos



Possible Decadron side effects / adverse reactions in 49 year old male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-10-06

Patient: 49 year old male

Reactions: Toxoplasmosis, Grand MAL Convulsion, Pneumonia Aspiration, Hemiparesis, Upper Motor Neurone Lesion, Lethargy, Decreased Appetite

Adverse event resulted in: death, hospitalization

Suspect drug(s):
Sulfamethoxazole and Trimethoprim

Decadron
    Indication: Immunosuppression

Tacrolimus
    Indication: Immunosuppression
    Start date: 2003-01-01
    End date: 2008-01-01

Sulfamethoxazole and Trimethoprim

Sulfamethoxazole and Trimethoprim
    Indication: Prophylaxis
    Start date: 2003-01-01

Sulfamethoxazole and Trimethoprim
    Indication: Immunosuppression
    Start date: 2003-01-01

Mycophenolate Mofetil
    Indication: Immunosuppression
    Start date: 2004-01-01

Prednisolone
    Indication: Immunosuppression
    Start date: 2003-01-01



See index of all Decadron side effect reports >>

Drug label data at the top of this Page last updated: 2007-01-09

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