Daraprim (Pyrimethamine) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

Hypersensitivity reactions, occasionally severe (such as Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, and anaphylaxis), and hyperphenylalaninemia, can occur particularly when pyrimethamine is administered concomitantly with a sulfonamide. Consult the complete prescribing information for the relevant sulfonamide for sulfonamide-associated adverse events. With doses of pyrimethamine used for the treatment of toxoplasmosis, anorexia and vomiting may occur. Vomiting may be minimized by giving the medication with meals; it usually disappears promptly upon reduction of dosage. Doses used in toxoplasmosis may produce megaloblastic anemia, leukopenia, thrombocytopenia, pancytopenia, atrophic glossitis, hematuria, and disorders of cardiac rhythm. Hematologic effects, however, may also occur at low doses in certain individuals (see PRECAUTIONS; General).

Pulmonary eosinophilia has been reported rarely.

REPORTS OF SUSPECTED DARAPRIM SIDE EFFECTS / ADVERSE REACTIONS

Possible Daraprim side effects / adverse reactions in 47 year old female

Reported by a individual with unspecified qualification from United Kingdom on 2011-10-03

Patient: 47 year old female

Reactions: Cardiac Murmur, Mouth Ulceration, Pancytopenia, Blood Folate Increased, Headache, Accidental Overdose, Tremor, Anaemia Vitamin B12 Deficiency, Speech Disorder, Malaise, Fatigue, Palpitations, Abdominal Distension, Serum Ferritin Decreased, Asthenia

Suspect drug(s):
Daraprim

Other drugs received by patient: Fybogel Sachets

Possible Daraprim side effects / adverse reactions in 54 year old male

Reported by a physician from United States on 2012-03-20

Patient: 54 year old male

Reactions: Exophthalmos, Respiratory Disorder, Pancytopenia, Toxicity TO Various Agents, Haemodynamic Instability, Mental Impairment, Zygomycosis, Bone Marrow Failure, Blindness Unilateral, Sinusitis Fungal, Eyelid Ptosis, Ophthalmoplegia, Maculopathy

Adverse event resulted in: death, hospitalization, disablity

Suspect drug(s):
Clindamycin
    Indication: Cerebral Toxoplasmosis

Dapsone
    Indication: Antifungal Prophylaxis

Daraprim
    Indication: Cerebral Toxoplasmosis

Dexamethasone
    Indication: Brain Oedema

Other drugs received by patient: Insulin

Possible Daraprim side effects / adverse reactions in 38 year old female

Reported by a physician from Germany on 2012-07-17

Patient: 38 year old female

Reactions: Phenylketonuria, Amino Acid Level Increased, Maternal Exposure During Pregnancy, Condition Aggravated, Transaminases Increased

Suspect drug(s):
Daraprim

Other drugs received by patient: Leucovorin Calcium; Vitamin B12 + Folic Acid; Sulphadiazine; Spiramycin