ADVERSE REACTIONS
Certain side effects characteristic of carbonic anhydrase inhibitors may occur with DARANIDE, particularly with increasing doses.
The most common effects include gastrointestinal disturbances (anorexia, nausea, and vomiting), drowsiness and paresthesias.
Included in the listing which follows are some adverse reactions which have not been reported with DARANIDE. However, pharmacological similarities among the carbonic anhydrase inhibitors make it advisable to consider the following reactions when diclorphenamide is administered. Central Nervous System/Psychiatric: ataxia, tremor, tinnitus, headache, weakness, nervousness, globus hystericus, lassitude, depression, confusion, disorientation, dizziness;
Gastrointestinal: constipation, hepatic insufficiency;
Metabolic: loss of weight, metabolic acidosis, electrolyte imbalance (hypokalemia, hyperchloremia), hyperuricemia;
Hypersensitivity: skin eruptions, pruritus, fever;
Hematologic: leukopenia, agranulocytosis, thrombocytopenia;
Genitourinary: urinary frequency, renal colic, renal calculi, phosphaturia.
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