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Dapsone (Dapsone) - Summary



Dapsone-USP, 4,4'-diaminodiphenylsulfone (DDS), is a primary treatment for Dermatitis herpetiformis. It is an antibacterial drug for susceptible cases of leprosy. It is a white, odorless crystalline powder, practically in-soluble in water and insoluble in fixed and vegetable oils.
Dapsone is issued on prescription in tablets of 25 and 100 mg for oral use.

DAPSONE is indicated for the following:

Dermatitis herpetiformis: (D.H.)

Leprosy: All forms of leprosy except for cases of proven Dapsone resistance.

See all Dapsone indications & dosage >>


Published Studies Related to Dapsone

Erosive pustular dermatosis of the scalp: A review with a focus on dapsone therapy. [2011.11.08]
CONCLUSION: Our observations demonstrate topical dapsone 5% gel to be a novel, safe, and efficacious therapeutic alternative for mild to moderate EPDS. Copyright (c) 2011 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

Dapsone gel 5% in combination with adapalene gel 0.1%, benzoyl peroxide gel 4% or moisturizer for the treatment of acne vulgaris: a 12-week, randomized, double-blind study. [2010.01]
PURPOSE: To evaluate the safety and efficacy of dapsone gel 5% in the treatment of acne when used in combination with adapalene gel 0.1%, benzoyl peroxide gel 4% or moisturizer... CONCLUSION: Dapsone gel in combination with adapalene gel or benzoyl peroxide gel is safe and well tolerated for the treatment of acne vulgaris.

Chlorproguanil-dapsone-artesunate versus chlorproguanil-dapsone: a randomized, double-blind, phase III trial in African children, adolescents, and adults with uncomplicated Plasmodium falciparum malaria. [2009.12]
This multi-center, randomized, parallel-group, double-blind, double-dummy study compared the efficacy and safety of chlorproguanil-dapsone-artesunate (CDA) and chlorproguanil-dapsone (CPG-DDS) in the treatment of falciparum malaria in Africa (Burkina Faso, Ghana, Mali, Nigeria)... However, the hemolytic potential in G6PD-deficient patients does not support further development of CDA.

Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi. [2009.08.26]
BACKGROUND: Sulphadoxine-pyrimethamine (SP) is the only single dose therapy for uncomplicated malaria, but there is widespread resistance. At the time of this study, artemether-lumefantrine (AL) and chlorproguanil-dapsone (CPD), both multi-dose regimes, were considered possible alternatives to SP in Malawi. The aim of this study was to investigate the impact of poor adherence on the effectiveness of AL and CPD... CONCLUSION: This study provides reassurance of the effectiveness of AL, even with unsupervised dosing, as it is rolled out across sub-Saharan Africa. Self-reported adherence appears to be an unreliable measure of adherence in this population.

Short report: comparison of chlorproguanil-dapsone with a combination of sulfadoxine-pyrimethamine and chloroquine in children with malaria in northcentral Nigeria. [2009.02]
Effective and affordable treatment of malaria is critical in the face of resistance of Plasmodium falciparum to chloroquine (CQ) and sulfadoxine-pyrimethamine (SP). We conducted a randomized controlled trial comparing the efficacy of chlorproguanil-dapsone (CD) with a combination SP plus CQ in children in Nigeria less than five years of age with malaria...

more studies >>

Clinical Trials Related to Dapsone

Use of Dapsone Gel, 5% for Treating Dermatitis Herpetiformis [Not yet recruiting]
The primary objective of this study is to evaluate the efficacy of dapsone gel, 5% in the treatment of dermatitis herpetiformis. The primary efficacy end point will be the proportion of patients achieving success based on mean % reduction from baseline in total lesion counts at week six. Success for lesion reduction will be defined as statistically greater mean percent reductions at week six in the dapsone gel-treated extremity compared with the control extremity of each patient.

Safety, Tolerability, and Pharmacokinetics of Dapsone in Acne Vulgaris [Completed]
This study will evaluate the safety, tolerability, and pharmacokinetics (PK) of dapsone in subjects with acne vulgaris following 28 days of dosing.

Pharmacokinetics and Distribution of Dapsone in Leucocytes After Single-dose and Multiple-dose Administration [Completed]
The objectives of the study are

- to evaluate pharmacokinetics, distribution in blood leucocytes, metabolism and

methemoglobinemia after single-dose and repeated-dose administration of 100 mg of dapsone in healthy subjects genotyped for CYP2C9 and NAT2

- to evaluate serum through levels, distribution in blood leucocytes and

methemoglobinemia after repeated-dose treatment with dapsone in patients with autoimmune bullous dermatoses before and after concomitant treatment with glucocorticoids

An Extension Study to Assess the Safety, Tolerability, Efficacy, and Treatment Adherence of Dapsone in Acne Vulgaris [Withdrawn]
This study will assess the safety, tolerability, and efficacy of dapsone in subjects with acne vulgaris following 12 weeks of treatment.

Effect of Weight and/or Obesity on Dapsone Drug Concentrations [Completed]
This study will find how weight affects the dosing of a drug called dapsone. Currently, the amount of dapsone a patient receives is the same regardless of the patient's weight.

more trials >>

Reports of Suspected Dapsone Side Effects

Methaemoglobinaemia (14)Pancytopenia (14)Zygomycosis (13)Toxicity TO Various Agents (12)Haemolytic Anaemia (10)Pyrexia (9)Ophthalmoplegia (7)Blindness Unilateral (6)Haemodynamic Instability (5)Herpes Zoster (5)more >>


Based on a total of 1 ratings/reviews, Dapsone has an overall score of 8. The effectiveness score is 10 and the side effect score is 6. The scores are on ten point scale: 10 - best, 1 - worst.

Dapsone review by 50 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Moderate Side Effects
Treatment Info
Condition / reason:   dermatitis herpetiformis
Dosage & duration:   200mg taken once a day for the period of 1 year and continuing
Other conditions:   celiac
Other drugs taken:   nil
Reported Results
Benefits:   Dapsone treated the intensly itchy skin condition quickly and efficiently. A gluten free diet alone did not relieve this condition.
Side effects:   The side effects after one year have been a slight decrease in red blood count. There has also been an onset of shakyness which I believe has been a side effect.
Comments:   2-100mg tablets are taken at bedtime. The dosage is self medicating, which means that if the condition is under control I can lower the doseage to see if the contrlo can be maintained at a lower dose. So far, after one year, I have been unable to do so.

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Page last updated: 2011-12-09

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