Danazol (Danazol) - Drug Interactions, Contraindications, Overdosage, etc

DRUG INTERACTIONS

Drug Interactions:

Prolongation of prothrombin time occurs in patients stabilized on warfarin. Therapy with danazol may cause an increase in carbamazepine levels in patients taking both drugs.

CONTRAINDICATIONS:

Danazol should not be administered to patients with:

1. Undiagnosed abnormal genital bleeding.
2. Markedly impaired hepatic, renal, or cardiac function.
3. Pregnancy. (See WARNINGS).
4. Breast feeding.
5. Porphyria - Danazol can induce ALA synthetase activity and hence porphyrin metabolism.