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Cytoxan (Cyclophosphamide) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

Information on adverse reactions associated with the use of CYTOXAN (cyclophosphamide) is arranged according to body system affected or type of reaction. The adverse reactions are listed in order of decreasing incidence. The most serious adverse reactions are described in the WARNINGS section.

Reproductive System

See WARNINGS for information on impairment of fertility.

Digestive System

Nausea and vomiting commonly occur with cyclophosphamide therapy. Anorexia and, less frequently, abdominal discomfort or pain and diarrhea may occur. There are isolated reports of hemorrhagic colitis, oral mucosal ulceration and jaundice occurring during therapy. These adverse drug effects generally remit when cyclophosphamide treatment is stopped.

Skin and Its Structures

Alopecia occurs commonly in patients treated with cyclophosphamide. The hair can be expected to grow back after treatment with the drug or even during continued drug treatment, though it may be different in texture or color. Skin rash occurs occasionally in patients receiving the drug. Pigmentation of the skin and changes in nails can occur. Very rare reports of Stevens-Johnson syndrome and toxic epidermal necrolysis have been received during postmarketing surveillance; due to the nature of spontaneous adverse event reporting, a definitive causal relationship to cyclophosphamide has not been established.

Hematopoietic System

Leukopenia occurs in patients treated with cyclophosphamide, is related to the dose of drug, and can be used as a dosage guide. Leukopenia of less than 2000 cells/mm3 develops commonly in patients treated with an initial loading dose of the drug, and less frequently in patients maintained on smaller doses. The degree of neutropenia is particularly important because it correlates with a reduction in resistance to infections. Fever without documented infection has been reported in neutropenic patients.

Thrombocytopenia or anemia develop occasionally in patients treated with CYTOXAN. These hematologic effects usually can be reversed by reducing the drug dose or by interrupting treatment. Recovery from leukopenia usually begins in 7 to 10 days after cessation of therapy.

Urinary System

See WARNINGS for information on cystitis and urinary bladder fibrosis.

Hemorrhagic ureteritis and renal tubular necrosis have been reported to occur in patients treated with cyclophosphamide. Such lesions usually resolve following cessation of therapy.

Infections

See WARNINGS for information on reduced host resistance to infections.

Carcinogenesis

See WARNINGS for information on carcinogenesis.

Respiratory System

Interstitial pneumonitis has been reported as part of the postmarketing experience. Interstitial pulmonary fibrosis has been reported in patients receiving high doses of cyclophosphamide over a prolonged period.

Other

Anaphylactic reactions have been reported; death has also been reported in association with this event. Possible cross-sensitivity with other alkylating agents has been reported. SIADH (syndrome of inappropriate ADH secretion) has been reported with the use of cyclophosphamide. Malaise and asthenia have been reported as part of the postmarketing experience.



REPORTS OF SUSPECTED CYTOXAN SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Cytoxan. The information is not vetted and should not be considered as verified clinical evidence.

Possible Cytoxan side effects / adverse reactions in 56 year old female

Reported by a consumer/non-health professional from United States on 2011-10-11

Patient: 56 year old female weighing 100.0 kg (220.0 pounds)

Reactions: Dysstasia, Muscular Weakness, Paraesthesia

Adverse event resulted in: hospitalization

Suspect drug(s):
Cytoxan
    Dosage: 1248 mg
    Indication: Adjuvant Therapy
    Start date: 2011-09-06
    End date: 2011-09-27

Cytoxan
    Dosage: 1248 mg
    Indication: Breast Cancer
    Start date: 2011-09-06
    End date: 2011-09-27

Other drugs received by patient: Docetaxel; Docetaxel



Possible Cytoxan side effects / adverse reactions in 70 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2011-10-12

Patient: 70 year old female weighing 60.0 kg (132.0 pounds)

Reactions: Arthralgia, Diarrhoea, Pyrexia, Headache

Adverse event resulted in: hospitalization

Suspect drug(s):
Rituximab
    Dosage: day 4 every 28 days x 6 cycles
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2011-04-19
    End date: 2011-05-02

Fludarabine Phosphate
    Dosage: day 1-3 every days x 6 cycles
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2011-04-19
    End date: 2011-05-02

Cytoxan
    Dosage: day1-3 every 28 days x cycle
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2011-04-19
    End date: 2011-05-02



Possible Cytoxan side effects / adverse reactions in 48 year old female

Reported by a physician from United States on 2011-10-19

Patient: 48 year old female

Reactions: Squamous Cell Carcinoma of Skin

Suspect drug(s):
Dapsone
    Indication: Behcet's Syndrome

Mycophenolate Mofetil (Cellcept)
    Indication: Behcet's Syndrome

Leukeran
    Indication: Behcet's Syndrome

Imuran
    Indication: Behcet's Syndrome

Enbrel
    Indication: Behcet's Syndrome

Prednisone
    Indication: Behcet's Syndrome

Methotrexate
    Indication: Behcet's Syndrome

Plaquenil
    Indication: Behcet's Syndrome

Cyclosporine
    Indication: Behcet's Syndrome

Remicade
    Indication: Behcet's Syndrome

Rituxan
    Indication: Behcet's Syndrome

Colchicine
    Indication: Behcet's Syndrome

Cytoxan
    Indication: Behcet's Syndrome

Arava
    Indication: Behcet's Syndrome

Other drugs received by patient: Pregabalin; Acyclovir; Folic Acid; Furosemide; Terbutaline Sulfate; Erythromycin; Esomeprazole Sodium; Pentoxifylline; Theophylline; Fentanyl-100; Fluticasone Propionate/salmeterol; Sertraline Hydrochloride



See index of all Cytoxan side effect reports >>

Drug label data at the top of this Page last updated: 2006-10-10

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