The toxic dose of misoprostol in humans has not been determined.
Cumulative total daily doses of 1600 mcg have been tolerated, with only symptoms
of gastrointestinal discomfort being reported.
In animals, the acute toxic effects are diarrhea, gastrointestinal lesions,
focal cardiac necrosis, hepatic necrosis, renal tubular necrosis, testicular
atrophy, respiratory difficulties, and depression of the central nervous system.
Clinical signs that may indicate an overdose are sedation, tremor, convulsions,
dyspnea, abdominal pain, diarrhea, fever, palpitations, hypotension, or
bradycardia.Symptoms should be treated with supportive therapy.
It is not known if misoprostol acid is dialyzable. However, because
misoprostol is metabolized like a fatty acid, it is unlikely that dialysis would
be appropriate treatment for overdosage.