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Cytomel (Liothyronine Sodium) - Summary

 
 



Drugs with thyroid hormone activity, alone or together with other therapeutic agents, have been used for the treatment of obesity. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects.

 

CYTOMEL SUMMARY

Cytomel (liothyronine sodium) Tablets contain liothyronine (L-triiodothyronine or LT3), a synthetic form of a natural thyroid hormone, and is available as the sodium salt.

Thyroid hormone drugs are indicated:

  1. As replacement or supplemental therapy in patients with hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis. This category includes cretinism, myxedema and ordinary hypothyroidism in patients of any age (pediatric patients, adults, the elderly), or state (including pregnancy); primary hypothyroidism resulting from functional deficiency, primary atrophy, partial or total absence of thyroid gland, or the effects of surgery, radiation, or drugs, with or without the presence of goiter; and secondary (pituitary) or tertiary (hypothalamic) hypothyroidism (see WARNINGS).

  2. As pituitary thyroid-stimulating hormone (TSH) suppressants, in the treatment or prevention of various types of euthyroid goiters, including thyroid nodules, subacute or chronic lymphocytic thyroiditis (HashimotoÂ’s) and multinodular goiter.

  3. As diagnostic agents in suppression tests to differentiate suspected mild hyperthyroidism or thyroid gland autonomy.

Cytomel (liothyronine sodium) Tablets can be used in patients allergic to desiccated thyroid or thyroid extract derived from pork or beef.


See all Cytomel indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Cytomel (Liothyronine)

Metabolic effects of liothyronine therapy in hypothyroidism: a randomized, double-blind, crossover trial of liothyronine versus levothyroxine. [2011]
CONCLUSIONS: The substitution of L-T(3) for L-T(4) at equivalent doses (relative

The pharmacodynamic equivalence of levothyroxine and liothyronine: a randomized, double blind, cross-over study in thyroidectomized patients. [2010.05]
CONTEXT: The substitution of liothyronine (L-T3) for levothyroxine (L-T4) is commonly employed during thyroid hormone (TH) withdrawal in preparation for diagnostic and therapeutic interventions on thyroid cancer patients. Presently, only limited data are available on the L-T3 for L-T4 therapeutic substitution. Objective To characterize the pharmcodynamic equivalence of L-T3 and L-T4... CONCLUSIONS: This is the first study addressing the equivalency between L-T3 and L-T4 therapy measured by baseline and TRH-stimulated TSH. The therapeutic substitution of L-T3 for L-T4 was achieved at approximately 1:3 ratio.

The pharmacodynamic equivalence of levothyroxine and liothyronine: a randomized, double blind, cross-over study in thyroidectomized patients. [2010]
Objective To characterize the pharmcodynamic equivalence of L-T3 and L-T4... CONCLUSIONS: This is the first study addressing the equivalency between L-T3 and

Efficacy of combined levothyroxine and liothyronine as compared with levothyroxine monotherapy in primary hypothyroidism: a randomized controlled trial. [2009]
OBJECTIVES: To examine the efficacy of combination therapy with levothyroxine and liothyronine in improvement of general health, psychological problems, and metabolic status in primary hypothyroidism... CONCLUSIONS: The data do not support the hypothesis that combined therapy improves the well-being and general health of patients.

Combined treatment with sertraline and liothyronine in major depression: a randomized, double-blind, placebo-controlled trial. [2007.06]
BACKGROUND: Antidepressant treatments that achieve a higher remission rate than those currently available are urgently needed. The thyroid hormone triiodothyronine may potentiate antidepressant effects. OBJECTIVE: To determine the antidepressant efficacy and safety of liothyronine sodium (triiodothyronine) when administered concurrently with the selective serotonin reuptake inhibitor sertraline hydrochloride to patients with major depressive disorder... CONCLUSIONS: These results demonstrate enhancement of the antidepressant effect of sertraline by concurrent treatment with liothyronine without a significant increase in adverse effects. The antidepressant effect of liothyronine may be directly linked to thyroid function.

more studies >>

Clinical Trials Related to Cytomel (Liothyronine)

Liothyronine and Heart Failure. The Long Term Effect of Liothyronine on Left Ventricular Ejection Fraction (LVEF) [Completed]
Purpose: The purpose of the study is to examine if treatment with liothyronine increases left ventricular ejection fraction (LVEF) in patients with stable, chronic heart failure.

Combined Levothyroxine/Liothyronine Supplementation in Hypothyroid Patients With Brain Tumors [Terminated]
Primary Objectives: 1. Assess whether combined treatment with Levothyroxine and Liothyronine improves learning and memory. 2. Explore the relationship between T3 treatment and other domains of cognitive function, quality of life, and mood.

Can Oral T3 Normalize Thyroid Hormone Levels Following Cardiopulmonary Bypass in Children? [Completed]
Low triiodothyronine (T3) syndrome defines as decrease of T3 levels during critically ill. This decrease of T3 levels was observed after congenital heart surgery using cardiopulmonary bypass. Previous largest study,Triiodothyronine for Infants and Children Undergoing Cardiopulmonary bypass (TRICC) study showed T3 supplementation decreased time to extubation for infants less than 5 months undergoing cardiopulmonary bypass. Intravenous regiment was known effective in maintaining T3 levels during pediatric cardiac surgery. This drug preparation however is not commonly used in many countries due to the relatively high costs and/or the simple lack of availability. The use of oral T3 to treat postoperative low T3 levels in pediatric patients has not been reported so far, although recent adult studies showed benefit in using oral T3 after cardiac surgery. The purpose of this study was to determine if oral T3 supplementation could prevent the decline of serum T3 in children less than 2 years of age undergoing congenital heart surgery using CPB.

Liothyronine (T3) for Bipolar Depression [Completed]
This study evaluates the efficacy of the thyroid hormone T3 for depression in patients with bipolar disorder. In this study patients will be randomized to receive T3 or placebo.

Evaluation of Integration Success and Crestal Bone Preservation Biomet 3i's T3 Implant System [Active, not recruiting]
This study evaluates the T3 implant system for the preservation of alveolar crestal bone and the establishment of initial integration. The new surface-treated features of the implant may contribute to improved soft and hard tissue healing. The success rate of the T3 implant will be no different than that of the control implant, which possess similar geometry but different surface treatments.

more trials >>

Reports of Suspected Cytomel (Liothyronine) Side Effects

Drug Ineffective (14)Alopecia (10)Feeling Abnormal (10)Fatigue (7)Headache (6)Dizziness (6)Anxiety (6)Weight Increased (5)Dyspnoea (5)Nausea (5)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 4 ratings/reviews, Cytomel has an overall score of 9.50. The effectiveness score is 9.50 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Cytomel review by 56 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   hypothyroidism
Dosage & duration:   5 mcg (dosage frequency: 2 per day) for the period of still taking it - 4 years
Other conditions:   none
Other drugs taken:   Levoxyl
  
Reported Results
Benefits:   Levoxyl improved lab results, but I still felt tired, had dry skin and some constipation. Adding Cytomel fine tuned treatment and all symptoms resolved.
Side effects:   There were none - all I felt was better.
Comments:   I took 100 mg Levoxyl, which provides a thyroid hormone called T4. It's success depends on the body's ability to convert T4 to T3; adding Cytomel proves T3 (the active hormone) directly. I now take 10 mcg Cytomel along with 100 mg Levoxyl and symptoms of low thyroid have resolved.

 

Cytomel review by 45 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Hypothyroid - Hashimoto's disease
Dosage & duration:   5mcg tablet taken 2 times per day for the period of still taking it (5 years so far)
Other conditions:   very tired, no energy, foggy memory
Other drugs taken:   Levothyroxine 112mcg; omeprazole 20mg; advair 250-50; maxair; fluticasone 50 mcg; Intal Inhaler
  
Reported Results
Benefits:   Increased energy and memory. Levothyroxine treatment alone was not working well. The combination works much better.
Side effects:   None
Comments:   Since being diagnosed with hypothyroidism, my doctor’s would treat with basically the Levothyroxine. The levels would be increased until I was “in the range”, but I never felt quite right. I was still very tired and my memory, especially short-term, was really bad. I went to a couple endocrinologists, with the first one diagnosing the hypothyroidism as a result of Hashimoto’s disease. Even with this diagnosis, the first endocrinologist did not suggest other treatments and I continued to suffer with excessive tiredness and memory problems. I decided to go for a second opinion, and this endocrinologist told me that some individuals react better with a combination treatment of Levothyroxine and Cytomel. This seemed to turn me around. The memory and tiredness have gotten better, still not optimal. It seems as long as one is “in the range”, doctors are hesitant to push the envelope. I would like to see physicians listen to their patients and adjust the meds until they feel better, not just go “by the range”.

 

Cytomel review by 45 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Hypothyroid - Hashimoto's disease
Dosage & duration:   5mcg tablet taken 2 times per day for the period of still taking it (5 years so far)
Other conditions:   very tired, no energy, foggy memory
Other drugs taken:   Levothyroxine 112mcg; omeprazole 20mg; advair 250-50; maxair; fluticasone 50 mcg; Intal Inhaler
  
Reported Results
Benefits:   Increased energy and memory. Levothyroxine treatment alone was not working well. The combination works much better.
Side effects:   None
Comments:   Since being diagnosed with hypothyroidism, my doctor’s would treat with basically the Levothyroxine. The levels would be increased until I was “in the range”, but I never felt quite right. I was still very tired and my memory, especially short-term, was really bad. I went to a couple endocrinologists, with the first one diagnosing the hypothyroidism as a result of Hashimoto’s disease. Even with this diagnosis, the first endocrinologist did not suggest other treatments and I continued to suffer with excessive tiredness and memory problems. I decided to go for a second opinion, and this endocrinologist told me that some individuals react better with a combination treatment of Levothyroxine and Cytomel. This seemed to turn me around. The memory and tiredness have gotten better, still not optimal. It seems as long as one is “in the range”, doctors are hesitant to push the envelope. I would like to see physicians listen to their patients and adjust the meds until they feel better, not just go “by the range”.

See all Cytomel reviews / ratings >>

Page last updated: 2013-02-10

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