Cytomel (Liothyronine Sodium) - Summary

CYTOMEL SUMMARY

CYTOMEL^®
brand of liothyronine sodium tablets

Thyroid hormone drugs are natural or synthetic preparations containing tetraiodothyronine (T₄, levothyroxine) sodium or triiodothyronine (T₃, liothyronine) sodium or both. T₄ and T₃ are produced in the human thyroid gland by the iodination and coupling of the amino acid tyrosine. T₄ contains four iodine atoms and is formed by the coupling of two molecules of diiodotyrosine (DIT). T₃ contains three atoms of iodine and is formed by the coupling of one molecule of DIT with one molecule of monoiodotyrosine (MIT). Both hormones are stored in the thyroid colloid as thyroglobulin.

Thyroid hormone drugs are indicated:

1. As replacement or supplemental therapy in patients with hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis. This category includes cretinism, myxedema and ordinary hypothyroidism in patients of any age (pediatric patients, adults, the elderly), or state (including pregnancy); primary hypothyroidism resulting from functional deficiency, primary atrophy, partial or total absence of thyroid gland, or the effects of surgery, radiation, or drugs, with or without the presence of goiter; and secondary (pituitary) or tertiary (hypothalamic) hypothyroidism (see WARNINGS).
2. As pituitary thyroid-stimulating hormone (TSH) suppressants, in the treatment or prevention of various types of euthyroid goiters, including thyroid nodules, subacute or chronic lymphocytic thyroiditis (Hashimoto's) and multinodular goiter.
3. As diagnostic agents in suppression tests to differentiate suspected mild hyperthyroidism or thyroid gland autonomy.

Cytomel (liothyronine sodium) Tablets can be used in patients allergic to desiccated thyroid or thyroid extract derived from pork or beef.

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CYTOMEL NEWS HIGHLIGHTS

Published Studies Related to Cytomel (Liothyronine)

Combined treatment with sertraline and liothyronine in major depression: a randomized, double-blind, placebo-controlled trial. [2007.06]

Comparative bioavailability of different formulations of levothyroxine and liothyronine in healthy volunteers. [2006.12]

Substitution of liothyronine at a 1:5 ratio for a portion of levothyroxine: effect on fatigue, symptoms of depression, and working memory versus treatment with levothyroxine alone. [2005.07]

Combined therapy with levothyroxine and liothyronine in two ratios, compared with levothyroxine monotherapy in primary hypothyroidism: a double-blind, randomized, controlled clinical trial. [2005.05]

Thyroid hormone replacement therapy in primary hypothyroidism: a randomized trial comparing L-thyroxine plus liothyronine with L-thyroxine alone. [2005.03.15]

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Clinical Trials Related to Cytomel (Liothyronine)

Triiodothyronine (T3) Supplementation in the Treatment of Bipolar and Unipolar Depression. [Completed]

Effect of T4-T3 Combination Therapy Versus T4 Monotherapy in Patients With Hypothyroidism [Completed]

Augmentation of the Antidepressant Action of Sertraline With Triiodothyronine (T3)and Reboxetine: Clinical Efficacy, Adverse Effects and Predictors of Response. [Not yet recruiting]

Combined Levothyroxine/Liothyronine Supplementation in Hypothyroid Patients With Brain Tumors [Recruiting]

Study of T3 on the Incidence of Atrial Fibrillation in Patients Undergoing Cardiac Surgery [Completed]

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