Cystadane (Betaine) - Summary

CYSTADANE SUMMARY

Cystadane® (betaine anhydrous for oral solution)

Cystadane^® (betaine anhydrous for oral solution) is an agent for the treatment of homocystinuria. Cystadane is a white, granular, hygroscopic powder. It contains no ingredients other than anhydrous betaine. Betaine anhydrous powder is very soluble in water, soluble in methanol and ethanol, and sparingly soluble in ether.

Cystadane (betaine anhydrous for oral solution) is indicated for the treatment of homocystinuria to decrease elevated homocysteine blood levels. Included within the category of homocystinuria are deficiencies or defects in:

1. cystathionine beta-synthase (CBS),
2. 5,10-methylenetetrahydrofolate reductase (MTHFR),
3. cobalamin cofactor metabolism (cbl).

Patient response to Cystadane can be monitored by homocysteine plasma levels (see DOSAGE AND ADMINISTRATION). Response usually occurs within a week and steady state within a month.

Cystadane has been administered concomitantly with vitamin B₆ (pyridoxine), vitamin B₁₂ (cobalamin), and folate.

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CYSTADANE NEWS HIGHLIGHTS

Published Studies Related to Cystadane (Betaine)

Influence of betaine consumption on strenuous running and sprinting in a hot environment. [2008.05]

Dietary and supplementary betaine: acute effects on plasma betaine and homocysteine concentrations under standard and postmethionine load conditions in healthy male subjects. [2008.03]

Synergistic effects of betaine and conjugated linoleic acid on the growth and carcass composition of growing Iberian pigs. [2008.01]

Effects of orange juice and proline betaine on glycine betaine and homocysteine in healthy male subjects. [2007.12]

The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people. [2007.11]

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Clinical Trials Related to Cystadane (Betaine)

Efficacy of Betaine for Reduction of Urine Oxalate in Patients With Type 1 Primary Hyperoxaluria [Recruiting]

Pilot Comparison of Standard Antiviral Therapy With and Without 12 Weeks of Betaine in Genotype 1 Naive Patients [Not yet recruiting]

Chronic Hepatitis C Non-Responder Study With AdoMet and Betaine [Recruiting]

Effect of Betaine and Folic Acid on Vascular Function in Healthy Humans [Completed]

Effect of Betaine, Serine and Folic Acid on Vascular Function in Healthy Volunteers [Completed]

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