CYPROHEPTADINE SUMMARY
Cyproheptadine HCl USP, is an antihistaminic and antiserotonergic agent.
CYPROHEPTADINE is indicated for the following:
Perennial and seasonal allergic rhinitis
Vasomotor rhinitis
Allergic conjunctivitis due to inhalant allergens and foods
Mild, uncomplicated allergic skin manifestations of urticaria and angioedema.
Amelioration of allergic reactions to blood or plasma
Cold urticaria
Dermatographism
As therapy for anaphylactic reactions adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled.
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NEWS HIGHLIGHTS
Published Studies Related to Cyproheptadine
Cyproheptadine for prevention of neuropsychiatric adverse effects of efavirenz: a
randomized clinical trial. [2013] Cyproheptadine prevention of the neuropsychiatric adverse effects of an
antiretroviral regimen including efavirenz has been evaluated in a randomized
clinical trial. Twenty-five patients (16 males and 9 females with mean±SD ages of
36±9 years) in a cyproheptadine group, and 26 patients (17 males and 9 females
with mean±SD ages of 34±7 years) in a control group completed the trial...
Short-term cyproheptadine therapy in underweight children: effects on growth and serum insulin-like growth factor-I. [2009.05] BACKGROUND: Cyproheptadine, an appetite stimulant, has been used in poor-appetite underweight children. Its beneficial effects on enhancing growth rate have been demonstrated. In contrast, an adverse effect on blunting growth hormone (GH) secretion has also been reported. To date, however, its effect on insulinlike growth factor-I (IGF-I), a GH-mediated growth factor, has not been documented. AIM: To examine the effect of cyproheptadine therapy on growth and serum IGF-I in underweight children... CONCLUSION: Cyproheptadine therapy in underweight children increased caloric intake and serum IGF-I concentration and consequently enhanced growth velocity.
Cyproheptadine for the treatment of functional abdominal pain in childhood: a double-blinded randomized placebo-controlled trial. [2008.12] AIM: The management of functional abdominal pain (FAP) in children and adolescents is challenging for health care professionals, and there are only limited or inconclusive studies of pharmacologic or behavioral therapy in childhood FAP. The objective of this randomized placebo-controlled clinical trial was to determine the potential efficacy and safety of cyproheptadine in the treatment of pediatric FAP... CONCLUSION: Among children with functional abdominal pain, cyproheptadine is enough effective to improve the intensity and frequency of abdominal pain in a short-term period.
Cyproheptadine is an effective appetite stimulant in cystic fibrosis. [2004.08] Chronic pulmonary infection and intestinal malabsorption often lead to malnutrition in children and adults with cystic fibrosis (CF). Appetite stimulants, along with provision of adequate calories, may aid in overcoming nutritional deficits, allowing a better prognosis... In conclusion, CH appears to be an effective appetite stimulant with minimal side effects in children and adults with CF.
Cyproheptadine in the treatment of autistic disorder: a double-blind placebo-controlled trial. [2004.04] OBJECTIVE: Autism is a childhood-onset disorder of unknown, possibly of multiple aetiologies. The core symptoms of autism are abnormalities in social interaction, communication and behaviour. The involvement of neurotransmitters such as 5-HT has been suggested in neuropsychiatric disorders and particularly in autistic disorder. Increased platelet 5-HT levels were found in 40% of the autistic population, suggesting that hyperserotonaemia may be a pathologic factor in infantile autism. Therefore, it is of interest to assess the efficacy of cyproheptadine, a 5-HT2 antagonist in the treatment of autistic disorder. In this 8-week double-blind, placebo-controlled trial, we assessed the effects of cyproheptadine plus haloperidol in the treatment of autistic disorder... CONCLUSION: The results suggest that the combination of cyproheptadine with a conventional antipsychotic may be superior to conventional antipsychotic alone for children with autistic disorder. However the results need confirmation by a larger randomized controlled trial.
Clinical Trials Related to Cyproheptadine
Cyproheptadine Hydrochloride and Nutritional Supplementation in Treating Young Patients With Weight Loss With Cancer [Terminated]
RATIONALE: Cyproheptadine hydrochloride may help improve appetite and lessen weight loss
caused by cancer or cancer treatment. It is not yet known whether cyproheptadine
hydrochloride is more effective with or without nutritional supplementation in improving
weight and quality of life of young patients with weight loss caused by cancer or cancer
treatment.
PURPOSE: This randomized phase II trial is studying cyproheptadine hydrochloride to see how
well it works when given together with or without nutritional supplementation in treating
young patients with weight loss caused by cancer or cancer treatment.
A Placebo-controlled Crossover Trial Using Cyproheptadine To Treat Children With Functional Abdominal Pain [Recruiting]
The investigators hypothesize that using Cyproheptadine in a placebo-controlled crossover
trial would help relieve abdominal pain associated with FAP in children, achieving a greater
response than that observed with placebo. In addition to assessing self-report of pain and
other symptoms, the investigators also propose to perform experimental somatic pain testing
to determine if there is evidence of peripherally-maintained central sensitization in
children with FAP. The investigators also hypothesize that there will be an increase in
somatic pain threshold after completion of a Cyproheptadine course compared to baseline
testing prior to treatment, and compared to placebo. This would allow children with FAP to
return to normal function, improve symptoms and overall general well-being
Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment [Completed]
RATIONALE: Cyproheptadine and megestrol may improve appetite and help prevent weight loss in
children with cancer.
PURPOSE: This phase II trial is studying how well cyproheptadine and megestrol work in
improving appetite and preventing weight loss in children with cachexia caused by cancer or
cancer treatment.
Altering Activation Patterns Post-stroke [Not yet recruiting]
This study evaluates a new rehabilitation approach for stroke survivors in the chronic phase
of recovery in which the combination of drug therapy (cyproheptadine) and active movement
practice (AMP) is used to encourage increased voluntary muscle control and strength.
Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer [Terminated]
RATIONALE: Cyproheptadine hydrochloride may prevent weight loss caused by cancer or cancer
treatment. It is not yet known whether cyproheptadine is more effective than a placebo in
preventing weight loss in young patients receiving chemotherapy for cancer.
PURPOSE: This randomized phase III trial is studying cyproheptadine hydrochloride to see how
well it works in preventing weight loss in young patients receiving chemotherapy for cancer.
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 3 ratings/reviews, Cyproheptadine has an overall score of 6.33. The effectiveness score is 8.67 and the side effect score is 6.67. The scores are on ten point scale: 10 - best, 1 - worst.
| Cyproheptadine review by 20 year old female patient | | Rating |
Overall rating: | | |
Effectiveness: | | Highly Effective |
Side effects: | | No Side Effects | | Treatment Info |
Condition / reason: | | Allergy to trauma to the face. |
Dosage & duration: | | 25 (dosage frequency: i took it every night) for the period of everyday for about 2 months |
Other conditions: | | none |
Other drugs taken: | | none | | Reported Results |
Benefits: | | What I really like about this medication is that it cleared up my sinuses. I no longer experience the tingling feeling that I had in my cheeks and around my lip area. I am also very happy that the medication helped me with my allergies to dust and to the effects of dry air on my nose. It stopped my nightly nose bleeds. |
Side effects: | | There were two side effects to the drug. The first side effect was that I was very drowsy. I knew that this would be a side effect and so that is why I took the medication about a half hour to an hour before bed. Another side effect was an increase in appetite. I gained a few pounds because of an increase in appetite. |
Comments: | | For the treatment I was given a few options as to how I could take the medication. One option was to take 1/4 of the medicine at night and take a tablet of Zyrtec during the day time. Another option was that I could take 1/4 at night without the Zyrtec during the day. I was also allowed to take 1/2 a table to 1 whole tablet daily. I tried all of these and the one that worked the best for me was taking 1/2 a tablet at night everyday. |
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| Cyproheptadine review by 26 year old female patient | | Rating |
Overall rating: | | |
Effectiveness: | | Considerably Effective |
Side effects: | | Severe Side Effects | | Treatment Info |
Condition / reason: | | allergy, runny nose, hay fever |
Dosage & duration: | | 4mg x 3 taken 1 tablet a day for the period of 3 times separately, but stopped |
Other conditions: | | none |
Other drugs taken: | | no | | Reported Results |
Benefits: | | It stopped running nose and sneezing. |
Side effects: | | Terrible drowsiness and weakness, I could sleep all day then |
Comments: | | Just one pill and then I was unadequate on daytime, I had to stop, I didn't understand what happened and when with new doze drowsiness appeared again I understood what the problem was, and the third time I just tested to be sure, that I can't function normally with this drug, although it stopped running nose. |
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| Cyproheptadine review by 26 year old female patient | | Rating |
Overall rating: | | |
Effectiveness: | | Considerably Effective |
Side effects: | | Severe Side Effects | | Treatment Info |
Condition / reason: | | allergy, runny nose, hay fever |
Dosage & duration: | | 4mg x 3 taken 1 tablet a day for the period of 3 times separately, but stopped |
Other conditions: | | none |
Other drugs taken: | | no | | Reported Results |
Benefits: | | It stopped running nose and sneezing. |
Side effects: | | Terrible drowsiness and weakness, I could sleep all day then |
Comments: | | Just one pill and then I was unadequate on daytime, I had to stop, I didn't understand what happened and when with new doze drowsiness appeared again I understood what the problem was, and the third time I just tested to be sure, that I can't function normally with this drug, although it stopped running nose. |
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Page last updated: 2014-11-30
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