Cyklokapron (Tranexamic Acid) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

Gastrointestinal disturbances (nausea, vomiting, diarrhea) may occur but disappear when the dosage is reduced. Giddiness and hypotension have been reported occasionally. Hypotension has been observed when intravenous injection is too rapid. To avoid this response, the solution should not be injected more rapidly than 1 mL per minute.

Worldwide Postmarketing Reports

Thromboembolic events (e.g., deep vein thrombosis, pulmonary embolism, cerebral thrombosis, acute renal cortical necrosis, and central retinal artery and vein obstruction) have been rarely reported in patients receiving tranexamic acid for indications other than hemorrhage prevention in patients with hemophilia. However, due to the spontaneous nature of the reporting of medical events and the lack of controls, the actual incidence and causal relationship of drug and event cannot be determined.

REPORTS OF SUSPECTED CYKLOKAPRON SIDE EFFECTS / ADVERSE REACTIONS

Possible Cyklokapron side effects / adverse reactions in 55 year old male

Reported by a physician from Austria on 2012-04-04

Patient: 55 year old male

Reactions: Cardiomyopathy

Suspect drug(s):
Cyklokapron

Possible Cyklokapron side effects / adverse reactions in 71 year old male

Reported by a pharmacist from Australia on 2012-04-17

Patient: 71 year old male

Reactions: Death, Drug Administration Error, Accidental Overdose

Adverse event resulted in: death

Suspect drug(s):
Cyklokapron
    Dosage: 1 g, every 4 hrs

Cyklokapron
    Dosage: 5 g given instead of 1g

Possible Cyklokapron side effects / adverse reactions in 60 year old male

Reported by a pharmacist from United States on 2012-04-18

Patient: 60 year old male

Reactions: Pulmonary Embolism

Suspect drug(s):
Cyklokapron
    Dosage: 1000 mg, unk
    Indication: Procoagulant Therapy
    Start date: 2012-03-01
    End date: 2012-03-01

Lovenox
    Dosage: unk
    Indication: Deep Vein Thrombosis
    Start date: 2012-03-01