DOSAGE AND ADMINISTRATION
Immediately before dental extraction in patients with hemophilia, administer 10 mg per kg body weight of CYKLOKAPRON intravenously together with replacement therapy (see PRECAUTIONS). Following surgery, parenteral therapy, at a dose of 10 mg per kg body weight three to four times daily, may be used for 2 to 8 days.
Note: For patients with moderate to severe impaired renal function, the following dosages are recommended:
|Serum Creatinine (µmol/L)||Tranexamic Acid I.V. Dosage|
|120 to 250 (1.36 to 2.83 mg/dL)||10 mg/kg BID|
|250 to 500 (2.83 to 5.66 mg/dL)||10 mg/kg daily|
|>500 (>5.66 mg/dL)||10 mg/kg every 48 hours|
5 mg/kg every 24 hours
For intravenous infusion, CYKLOKAPRON Injection may be mixed with most solutions for infusion such as electrolyte solutions, carbohydrate solutions, amino acid solutions and Dextran solutions. The mixture should be prepared the same day the solution is to be used. Heparin may be added to CYKLOKAPRON Injection. CYKLOKAPRON Injection should NOT be mixed with blood. The drug is a synthetic amino acid, and should NOT be mixed with solutions containing penicillin.