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Cyklokapron (Tranexamic Acid) - Summary



tranexamic acid tablets and tranexamic acid injection

Each tablet contains 500 mg of tranexamic acid.Each mL of the sterile solution for intravenous injection contains 100 mg tranexamic acid and Water for Injection to 1 mL.

CYKLOKAPRON Tablets and Injection are indicated in patients with hemophilia for short term use (two to eight days) to reduce or prevent hemorrhage and reduce the need for replacement therapy during and following tooth extraction.

See all Cyklokapron indications & dosage >>


Published Studies Related to Cyklokapron (Tranexamic Acid)

Effect of tranexamic acid irrigation on perioperative blood loss during orthognathic surgery: a double-blind, randomized controlled clinical trial. [2015]
(TXA) irrigation on perioperative hemorrhage during orthognathic surgery... CONCLUSIONS: TXA is effective in reducing intraoperative blood loss in patients

Reduction in facial hyperpigmentation after treatment with a combination of topical niacinamide and tranexamic acid: a randomized, double-blind, vehicle-controlled trial. [2014]
pigmentation... CONCLUSION: A formulation containing the combination of niacinamide + TXA reduced

HALT-IT--tranexamic acid for the treatment of gastrointestinal bleeding: study protocol for a randomised controlled trial. [2014]
BACKGROUND: Gastrointestinal bleeding is a common emergency that causes substantial mortality worldwide. Acute upper and lower gastrointestinal bleeding accounts for about 75,000 hospital admissions each year in the UK and causes the death of about 10% of these patients... A study with 8,000 patients will have over 90% power to detect a 25% reduction in mortality from 10% to 7.5%.

Tranexamic acid for spontaneous intracerebral hemorrhage: a randomized controlled pilot trial (ISRCTN50867461). [2014]
trial of tranexamic acid in spontaneous ICH, ahead of a definitive study... CONCLUSIONS: This, the first randomized controlled trial of TA in ICH, found that

The spot sign and tranexamic acid on preventing ICH growth--AUStralasia Trial (STOP-AUST): protocol of a phase II randomized, placebo-controlled, double-blind, multicenter trial. [2014]
RATIONALE: No evidence-based acute therapies exist for intracerebral hemorrhage. Intracerebral hemorrhage growth is an important determinant of patient outcome... DISCUSSION: This is the first trial to evaluate the efficacy of tranexamic acid in intracerebral hemorrhage patients selected based on an imaging biomarker of high likelihood of hematoma growth.

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Clinical Trials Related to Cyklokapron (Tranexamic Acid)

Tranexamic Acid (TXA) in Pediatric Cardiac Surgery [Completed]
The purpose of this study is to determine tranexamic acid plasma levels in children undergoing cardiac surgery at risk of bleeding and to compare two dosing regimens.

Study of Tranexamic Acid for Reducing Blood Requirement in Patients Undergoing Major Gastro-intestinal Surgery [Active, not recruiting]
Primary objective of the study is to compare requirement of blood transfusion and mortality in patients receiving Tranexamic acid (Cyklokapron®) and those not receiving it. Secondary objective is to; assess the re-bleeding events; need for surgical intervention; length of stay in Intensive care unit in between the two groups.

Tranexamic Acid During Cystectomy Trial (TACT) Pilot Study [Recruiting]
A cystectomy is the removal of the bladder and adjacent organs in patients with bladder cancer. This often results in significant blood loss, and about 60% of patients will require a blood transfusion during or up to 30 days after surgery. Significant blood loss may result in cardiovascular morbidity, and the use of blood products are expensive and expose patients to risk. Tranexamic acid reduces breakdown of hemostatic blood clots and it has therapeutic benefit when used in other surgical procedures to reduce blood loss and the need for transfusion. The current study will be the first to evaluate whether tranexamic acid is effective and safe to use during radical cystectomy. The results of the study will have an immediate impact on patient care.

Tranexamic Acid for Unilateral Total Knee Arthroplasty [Completed]
Total knee arthroplasty is often associated with excessive postoperative bleeding due to increased fibrinolysis. Hence, the objective of the proposed of this multicentre study is to determine the peri-operative bleeding comparing the application of topical and intravenous tranexamic acid with the habitual surgical haemostasis.

Testing of the Drug Tranexamic Acids as Prophylaxis of Bleeding in Benign Surgical Removal of the Uterus [Active, not recruiting]
In Denmark, 4400 women annually undergo hysterectomy on benign background (surgical removal of the uterus). 10% of these women experience bleeding complications. The drug Tranexamic Acid (Cyklokapron) has showed significant reduction of bleeding in relation to other types of surgery. The hypothesis of this study is that Tranexamic Acid could also reduce the operative bleeding associated with benign hysterectomy. The study will be carried out as a randomized, placebo-controlled national multicenter trial

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Reports of Suspected Cyklokapron (Tranexamic Acid) Side Effects

Pulmonary Embolism (4)Hypersensitivity (1)Accidental Overdose (1)Cerebral Ischaemia (1)Encephalocele (1)Death (1)LOW SET Ears (1)Drug Administration Error (1)Dizziness (1)External Auditory Canal Atresia (1)more >>

Page last updated: 2015-08-10

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