NEWS HIGHLIGHTS
Published Studies Related to Cyklokapron (Tranexamic Acid)
Comparative evaluation of the effects of tranexamic acid and low-dose aprotinin
on post-valvular heart surgery bleeding and allogenic transfusion. [2012]
Bleeding diathesis and allogenic transfusion after complex heart surgery, such as
heart valve surgery, may result in complications such as transfusion reaction,
viral infection, postoperative infection, haemodynamic disturbance, prolonged
stay in the intensive care unit and hospital, renal and respiratory failure and
mortality...
Evaluation of the efficacy of tranexamic acid on blood loss in orthognathic
surgery. A prospective, randomized clinical study. [2012]
The purpose of this prospective, randomized, double blind study was to assess the
effect of tranexamic acid on blood loss, quality of surgical field and duration
of surgery in adolescent orthognathic surgery patients. 50 consecutive patients,
scheduled for orthognathic surgery were included...
Terlipressin for hepatorenal syndrome. [2012]
CONCLUSIONS: Terlipressin may reduce mortality and improve renal
A phase 2 prospective, randomized, double-blind trial comparing the effects of
tranexamic acid with ecallantide on blood loss from high-risk cardiac surgery
with cardiopulmonary bypass (CONSERV-2 Trial). [2012]
associated with cardiac surgery requiring cardiopulmonary bypass... CONCLUSIONS: Ecallantide was less effective at reducing perioperative blood loss
Reduction of blood loss in primary hip arthroplasty with tranexamic acid or fibrin spray. [2011.12]
Background and purpose Previous studies have shown that either fibrin spray or tranexamic acid can reduce blood loss at total hip replacement, but the 2 treatments have not been directly compared... Blood loss was similar in the fibrin spray group and in the tranexamic acid group.
Clinical Trials Related to Cyklokapron (Tranexamic Acid)
A Preliminary Study of a New Tranexamic Acid Dosing Schedule for Cardiac Surgery [Completed]
Tranexamic acid is administered intravenously to prevent bleeding associated with cardiac
surgery and cardiopulmonary bypass. We have developed an assay for tranexamic acid. We have
developed an alternative dosing schedule for tranexamic acid. The objective of this
preliminary study is to determine if this new dosing schedule can achieve the desired plasma
concentration of tranexamic acid and reduce intra and inter patient variability in tranexamic
acid plasma concentrations relative to the current dosing schedule.
Safety of Tranexamic Acid in Reducing Bleeding in Adults Undergoing Spinal Surgery [Completed]
Spinal fusion surgery can be associated with significant blood loss requiring allogeneic
blood transfusion. Tranexamic acid is a synthetic amino acid with antifibrinolytic action
that has been shown to reduce perioperative blood loss in patients undergoing cardiopulmonary
bypass for cardiac bypass surgery, knee replacement and liver transplantation surgeries. The
efficacy of antifibrinolytics for reduction of blood loss in major spine surgery has not been
well studied in adult patients. The objective of this study is to determine the efficacy of
tranexamic acid in reducing perioperative blood loss and blood transfusion in adults
undergoing elective spinal fusion in a larger, multi-centered, randomized, double-blinded,
placebo controlled trial.
Tranexamic Acid (TXA) in Pediatric Cardiac Surgery [Recruiting]
The purpose of this study is to determine tranexamic acid plasma levels in children
undergoing cardiac surgery at risk of bleeding and to compare two dosing regimens.
Effect of Tranexamic Acid in Upper Gastrointestinal Bleeding [Recruiting]
The investigators hypothesize that addition of Tranexamic acid, an antifibrinolytic agent,
to conventional therapy will lead to an improved outcome characterized by lower transfusion
requirements.
Intravenous Tranexamic Acid and Intraoperative Visualization During Functional Endoscopic Sinus Surgery [Recruiting]
Functional endoscopic sinus surgery (FESS) is an effective treatment of sinus disease. FESS
is carried out using cameras to view the surgical field. Bleeding during the surgery can
lead to poor surgical field visualization. Poor visualization has been associated with worse
surgical outcomes. Tranexamic acid is a safe and effective agent used to achieve hemostasis
during operative procedures. The current study is a randomized controlled trial in patients
undergoing FESS to compare the effects of tranexamic acid versus placebo and the effects on
surgical field visualization and adverse events.
Reports of Suspected Cyklokapron (Tranexamic Acid) Side Effects
Pulmonary Embolism (4),
Hypersensitivity (1),
Accidental Overdose (1),
Cerebral Ischaemia (1),
Encephalocele (1),
Death (1),
LOW SET Ears (1),
Drug Administration Error (1),
Dizziness (1),
External Auditory Canal Atresia (1), more >>
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