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Cyklokapron (Tranexamic Acid) - Summary

 
 



CYKLOKAPRON SUMMARY

Cyklokapron®
tranexamic acid tablets and tranexamic acid injection

Each tablet contains 500 mg of tranexamic acid.Each mL of the sterile solution for intravenous injection contains 100 mg tranexamic acid and Water for Injection to 1 mL.

CYKLOKAPRON Tablets and Injection are indicated in patients with hemophilia for short term use (two to eight days) to reduce or prevent hemorrhage and reduce the need for replacement therapy during and following tooth extraction.


See all Cyklokapron indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Cyklokapron (Tranexamic Acid)

Effect of tranexamic acid irrigation on perioperative blood loss during orthognathic surgery: a double-blind, randomized controlled clinical trial. [2015]
(TXA) irrigation on perioperative hemorrhage during orthognathic surgery... CONCLUSIONS: TXA is effective in reducing intraoperative blood loss in patients

Reduction in facial hyperpigmentation after treatment with a combination of topical niacinamide and tranexamic acid: a randomized, double-blind, vehicle-controlled trial. [2014]
pigmentation... CONCLUSION: A formulation containing the combination of niacinamide + TXA reduced

HALT-IT--tranexamic acid for the treatment of gastrointestinal bleeding: study protocol for a randomised controlled trial. [2014]
BACKGROUND: Gastrointestinal bleeding is a common emergency that causes substantial mortality worldwide. Acute upper and lower gastrointestinal bleeding accounts for about 75,000 hospital admissions each year in the UK and causes the death of about 10% of these patients... A study with 8,000 patients will have over 90% power to detect a 25% reduction in mortality from 10% to 7.5%.

Tranexamic acid for spontaneous intracerebral hemorrhage: a randomized controlled pilot trial (ISRCTN50867461). [2014]
trial of tranexamic acid in spontaneous ICH, ahead of a definitive study... CONCLUSIONS: This, the first randomized controlled trial of TA in ICH, found that

The spot sign and tranexamic acid on preventing ICH growth--AUStralasia Trial (STOP-AUST): protocol of a phase II randomized, placebo-controlled, double-blind, multicenter trial. [2014]
RATIONALE: No evidence-based acute therapies exist for intracerebral hemorrhage. Intracerebral hemorrhage growth is an important determinant of patient outcome... DISCUSSION: This is the first trial to evaluate the efficacy of tranexamic acid in intracerebral hemorrhage patients selected based on an imaging biomarker of high likelihood of hematoma growth.

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Clinical Trials Related to Cyklokapron (Tranexamic Acid)

A Preliminary Study of a New Tranexamic Acid Dosing Schedule for Cardiac Surgery [Completed]
Tranexamic acid is administered intravenously to prevent bleeding associated with cardiac surgery and cardiopulmonary bypass. We have developed an assay for tranexamic acid. We have developed an alternative dosing schedule for tranexamic acid. The objective of this preliminary study is to determine if this new dosing schedule can achieve the desired plasma concentration of tranexamic acid and reduce intra and inter patient variability in tranexamic acid plasma concentrations relative to the current dosing schedule.

Safety of Tranexamic Acid in Reducing Bleeding in Adults Undergoing Spinal Surgery [Completed]
Spinal fusion surgery can be associated with significant blood loss requiring allogeneic blood transfusion. Tranexamic acid is a synthetic amino acid with antifibrinolytic action that has been shown to reduce perioperative blood loss in patients undergoing cardiopulmonary bypass for cardiac bypass surgery, knee replacement and liver transplantation surgeries. The efficacy of antifibrinolytics for reduction of blood loss in major spine surgery has not been well studied in adult patients. The objective of this study is to determine the efficacy of tranexamic acid in reducing perioperative blood loss and blood transfusion in adults undergoing elective spinal fusion in a larger, multi-centered, randomized, double-blinded, placebo controlled trial.

Tranexamic Acid (TXA) in Pediatric Cardiac Surgery [Recruiting]
The purpose of this study is to determine tranexamic acid plasma levels in children undergoing cardiac surgery at risk of bleeding and to compare two dosing regimens.

Effect of Tranexamic Acid in Upper Gastrointestinal Bleeding [Recruiting]
The investigators hypothesize that addition of Tranexamic acid, an antifibrinolytic agent, to conventional therapy will lead to an improved outcome characterized by lower transfusion requirements.

Intravenous Tranexamic Acid and Intraoperative Visualization During Functional Endoscopic Sinus Surgery [Recruiting]
Functional endoscopic sinus surgery (FESS) is an effective treatment of sinus disease. FESS is carried out using cameras to view the surgical field. Bleeding during the surgery can lead to poor surgical field visualization. Poor visualization has been associated with worse surgical outcomes. Tranexamic acid is a safe and effective agent used to achieve hemostasis during operative procedures. The current study is a randomized controlled trial in patients undergoing FESS to compare the effects of tranexamic acid versus placebo and the effects on surgical field visualization and adverse events.

more trials >>

Reports of Suspected Cyklokapron (Tranexamic Acid) Side Effects

Pulmonary Embolism (4)Hypersensitivity (1)Accidental Overdose (1)Cerebral Ischaemia (1)Encephalocele (1)Death (1)LOW SET Ears (1)Drug Administration Error (1)Dizziness (1)External Auditory Canal Atresia (1)more >>


Page last updated: 2015-08-10

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