Media Articles Related to Cyklokapron (Tranexamic Acid)
Tranexamic Acid Cuts Post-Partum Bleeding Deaths (CME/CE)
Source: MedPage Today OB/Gyn [2017.04.26]
(MedPage Today) -- 'Inexpensive' therapy may help reduce worldwide maternal mortality
Low-cost drug reduces death due to bleeding in women with post-partum haemorrhage
Source: Pregnancy / Obstetrics News From Medical News Today [2017.04.27]
Tranexamic acid - an inexpensive and widely available drug - could reduce maternal deaths among women with severe bleeding after child birth, according to a global trial of 20,000 women in 21...
Cheap Drug Cuts Maternal Deaths Due to Postpartum Hemorrhage
Source: Medscape Critical Care Headlines [2017.04.26]
Early administration of tranexamic acid, an inexpensive antifibrinolytic drug, reduced the number of maternal deaths attributable to postpartum hemorrhage in a randomized controlled trial.
Medscape Medical News
Published Studies Related to Cyklokapron (Tranexamic Acid)
Effect of tranexamic acid irrigation on perioperative blood loss during
orthognathic surgery: a double-blind, randomized controlled clinical trial. 
(TXA) irrigation on perioperative hemorrhage during orthognathic surgery... CONCLUSIONS: TXA is effective in reducing intraoperative blood loss in patients
Reduction in facial hyperpigmentation after treatment with a combination of
topical niacinamide and tranexamic acid: a randomized, double-blind,
vehicle-controlled trial. 
pigmentation... CONCLUSION: A formulation containing the combination of niacinamide + TXA reduced
HALT-IT--tranexamic acid for the treatment of gastrointestinal bleeding: study
protocol for a randomised controlled trial. 
BACKGROUND: Gastrointestinal bleeding is a common emergency that causes
substantial mortality worldwide. Acute upper and lower gastrointestinal bleeding
accounts for about 75,000 hospital admissions each year in the UK and causes the
death of about 10% of these patients... A study with 8,000 patients will have over 90% power to detect a 25%
reduction in mortality from 10% to 7.5%.
Tranexamic acid for spontaneous intracerebral hemorrhage: a randomized controlled
pilot trial (ISRCTN50867461). 
trial of tranexamic acid in spontaneous ICH, ahead of a definitive study... CONCLUSIONS: This, the first randomized controlled trial of TA in ICH, found that
The spot sign and tranexamic acid on preventing ICH growth--AUStralasia Trial
(STOP-AUST): protocol of a phase II randomized, placebo-controlled, double-blind,
multicenter trial. 
RATIONALE: No evidence-based acute therapies exist for intracerebral hemorrhage. Intracerebral hemorrhage growth is an important determinant of patient outcome... DISCUSSION: This is the first trial to evaluate the efficacy of tranexamic acid
in intracerebral hemorrhage patients selected based on an imaging biomarker of
high likelihood of hematoma growth.
Clinical Trials Related to Cyklokapron (Tranexamic Acid)
Tranexamic Acid (TXA) in Pediatric Cardiac Surgery [Completed]
The purpose of this study is to determine tranexamic acid plasma levels in children
undergoing cardiac surgery at risk of bleeding and to compare two dosing regimens.
Study of Tranexamic Acid for Reducing Blood Requirement in Patients Undergoing Major Gastro-intestinal Surgery [Active, not recruiting]
Primary objective of the study is to compare requirement of blood transfusion and mortality
in patients receiving Tranexamic acid (Cyklokapron®) and those not receiving it.
Secondary objective is to; assess the re-bleeding events; need for surgical intervention;
length of stay in Intensive care unit in between the two groups.
Tranexamic Acid During Cystectomy Trial (TACT) Pilot Study [Recruiting]
A cystectomy is the removal of the bladder and adjacent organs in patients with bladder
cancer. This often results in significant blood loss, and about 60% of patients will require
a blood transfusion during or up to 30 days after surgery. Significant blood loss may result
in cardiovascular morbidity, and the use of blood products are expensive and expose patients
Tranexamic acid reduces breakdown of hemostatic blood clots and it has therapeutic benefit
when used in other surgical procedures to reduce blood loss and the need for transfusion.
The current study will be the first to evaluate whether tranexamic acid is effective and
safe to use during radical cystectomy. The results of the study will have an immediate
impact on patient care.
Tranexamic Acid for Unilateral Total Knee Arthroplasty [Completed]
Total knee arthroplasty is often associated with excessive postoperative bleeding due to
increased fibrinolysis. Hence, the objective of the proposed of this multicentre study is to
determine the peri-operative bleeding comparing the application of topical and intravenous
tranexamic acid with the habitual surgical haemostasis.
Testing of the Drug Tranexamic Acids as Prophylaxis of Bleeding in Benign Surgical Removal of the Uterus [Active, not recruiting]
In Denmark, 4400 women annually undergo hysterectomy on benign background (surgical removal
of the uterus). 10% of these women experience bleeding complications. The drug Tranexamic
Acid (Cyklokapron) has showed significant reduction of bleeding in relation to other types
of surgery. The hypothesis of this study is that Tranexamic Acid could also reduce the
operative bleeding associated with benign hysterectomy. The study will be carried out as a
randomized, placebo-controlled national multicenter trial
Reports of Suspected Cyklokapron (Tranexamic Acid) Side Effects
Pulmonary Embolism (4),
Accidental Overdose (1),
Cerebral Ischaemia (1),
LOW SET Ears (1),
Drug Administration Error (1),
External Auditory Canal Atresia (1), more >>