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Cyklokapron (Tranexamic Acid) - Summary

 
 



CYKLOKAPRON SUMMARY

Cyklokapron®
tranexamic acid tablets and tranexamic acid injection

Each tablet contains 500 mg of tranexamic acid.Each mL of the sterile solution for intravenous injection contains 100 mg tranexamic acid and Water for Injection to 1 mL.

CYKLOKAPRON Tablets and Injection are indicated in patients with hemophilia for short term use (two to eight days) to reduce or prevent hemorrhage and reduce the need for replacement therapy during and following tooth extraction.


See all Cyklokapron indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Cyklokapron (Tranexamic Acid)

Tranexamic Acid May Improve Orthopedic Surgery Outcomes
Source: Medscape General Surgery Headlines [2014.08.15]
Tranexamic acid appears to reduce both bleeding and thrombosis in patients undergoing orthopedic surgery.
Medscape Medical News

Clotting drug linked to fewer blood transfusions in joint surgery
Source: Blood / Hematology News From Medical News Today [2014.08.13]
Tranexamic acid has been shown to reduce blood loss during or shortly after major joint surgery (the perioperative stage).

more news >>

Published Studies Related to Cyklokapron (Tranexamic Acid)

Comparative evaluation of the effects of tranexamic acid and low-dose aprotinin on post-valvular heart surgery bleeding and allogenic transfusion. [2012]
Bleeding diathesis and allogenic transfusion after complex heart surgery, such as heart valve surgery, may result in complications such as transfusion reaction, viral infection, postoperative infection, haemodynamic disturbance, prolonged stay in the intensive care unit and hospital, renal and respiratory failure and mortality...

Evaluation of the efficacy of tranexamic acid on blood loss in orthognathic surgery. A prospective, randomized clinical study. [2012]
The purpose of this prospective, randomized, double blind study was to assess the effect of tranexamic acid on blood loss, quality of surgical field and duration of surgery in adolescent orthognathic surgery patients. 50 consecutive patients, scheduled for orthognathic surgery were included...

Terlipressin for hepatorenal syndrome. [2012]
CONCLUSIONS: Terlipressin may reduce mortality and improve renal

A phase 2 prospective, randomized, double-blind trial comparing the effects of tranexamic acid with ecallantide on blood loss from high-risk cardiac surgery with cardiopulmonary bypass (CONSERV-2 Trial). [2012]
associated with cardiac surgery requiring cardiopulmonary bypass... CONCLUSIONS: Ecallantide was less effective at reducing perioperative blood loss

Reduction of blood loss in primary hip arthroplasty with tranexamic acid or fibrin spray. [2011.12]
Background and purpose Previous studies have shown that either fibrin spray or tranexamic acid can reduce blood loss at total hip replacement, but the 2 treatments have not been directly compared... Blood loss was similar in the fibrin spray group and in the tranexamic acid group.

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Clinical Trials Related to Cyklokapron (Tranexamic Acid)

A Preliminary Study of a New Tranexamic Acid Dosing Schedule for Cardiac Surgery [Completed]
Tranexamic acid is administered intravenously to prevent bleeding associated with cardiac surgery and cardiopulmonary bypass. We have developed an assay for tranexamic acid. We have developed an alternative dosing schedule for tranexamic acid. The objective of this preliminary study is to determine if this new dosing schedule can achieve the desired plasma concentration of tranexamic acid and reduce intra and inter patient variability in tranexamic acid plasma concentrations relative to the current dosing schedule.

Safety of Tranexamic Acid in Reducing Bleeding in Adults Undergoing Spinal Surgery [Completed]
Spinal fusion surgery can be associated with significant blood loss requiring allogeneic blood transfusion. Tranexamic acid is a synthetic amino acid with antifibrinolytic action that has been shown to reduce perioperative blood loss in patients undergoing cardiopulmonary bypass for cardiac bypass surgery, knee replacement and liver transplantation surgeries. The efficacy of antifibrinolytics for reduction of blood loss in major spine surgery has not been well studied in adult patients. The objective of this study is to determine the efficacy of tranexamic acid in reducing perioperative blood loss and blood transfusion in adults undergoing elective spinal fusion in a larger, multi-centered, randomized, double-blinded, placebo controlled trial.

Tranexamic Acid (TXA) in Pediatric Cardiac Surgery [Recruiting]
The purpose of this study is to determine tranexamic acid plasma levels in children undergoing cardiac surgery at risk of bleeding and to compare two dosing regimens.

Effect of Tranexamic Acid in Upper Gastrointestinal Bleeding [Recruiting]
The investigators hypothesize that addition of Tranexamic acid, an antifibrinolytic agent, to conventional therapy will lead to an improved outcome characterized by lower transfusion requirements.

Intravenous Tranexamic Acid and Intraoperative Visualization During Functional Endoscopic Sinus Surgery [Recruiting]
Functional endoscopic sinus surgery (FESS) is an effective treatment of sinus disease. FESS is carried out using cameras to view the surgical field. Bleeding during the surgery can lead to poor surgical field visualization. Poor visualization has been associated with worse surgical outcomes. Tranexamic acid is a safe and effective agent used to achieve hemostasis during operative procedures. The current study is a randomized controlled trial in patients undergoing FESS to compare the effects of tranexamic acid versus placebo and the effects on surgical field visualization and adverse events.

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Reports of Suspected Cyklokapron (Tranexamic Acid) Side Effects

Pulmonary Embolism (4)Hypersensitivity (1)Accidental Overdose (1)Cerebral Ischaemia (1)Encephalocele (1)Death (1)LOW SET Ears (1)Drug Administration Error (1)Dizziness (1)External Auditory Canal Atresia (1)more >>


Page last updated: 2014-08-15

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