Published Studies Related to Cyclomydril (Cyclopentolate / Phenylephrine Ophthalmic)
Preoperative topical cyclopentolate can be omitted when using intracameral lidocaine in phacoemulsification surgery. [2009.05]
PURPOSE: To evaluate the mydriatic effect of topical cyclopentolate 1% when combined with topical phenylephrine 10% and intracameral lidocaine 1% in phacoemulsification cataract surgery... CONCLUSIONS: Preoperative topical cyclopentolate does not enhance mydriasis in phacoemulsification surgery when using intracameral lidocaine and can be omitted when intracameral lidocaine is used.
Separate and additive mydriatic effects of lidocaine hydrochloride, phenylephrine, and cyclopentolate after intracameral injection. [2008.02]
PURPOSE: To assess the separate mydriatic effect of lidocaine hydrochloride (Xylocaine), cyclopentolate, and phenylephrine after intracameral injection and evaluate whether intracameral Xylocaine and phenylephrine without cyclopentolate provide sufficient pupil dilation for cataract surgery. SETTING: Department of Clinical Science/Ophthalmology, Umea University Hospital, Umea, Sweden... CONCLUSIONS: Xylocaine plus phenylephrine injected intracamerally gave adequate intraoperative pupil dilation in routine phacoemulsification surgery. Cyclopentolate administrated intracamerally had no immediate additive mydriatic effect to intracameral Xylocaine combined with phenylephrine.
Combination cyclopentolate and phenylephrine for mydriasis in premature infants with heavily pigmented irides. [2000.01]
PURPOSE: This study examined whether safe and effective mydriasis can be achieved in premature infants with heavily pigmented irides using combination cyclopentolate 0.2% and phenylephrine 1% eyedrops... CONCLUSION: The single combination eyedrop of cyclopentolate 0.2% and phenylephrine 1% is as effective and safe a mydriatic for infants with dark irides as both tropicamide 0.5% and phenylephrine 2.5%.
Dilation efficacy: is 1% cyclopentolate enough? [2007.03]
BACKGROUND: Pediatric eye examinations include cycloplegia and dilation. Most clinicians use 2 or 3 different medications in drop or spray form to ease instillation. We studied whether a single drop of a cycloplegic agent would provide effective dilation as well... CONCLUSIONS: One drop of 1% cyclopentolate provides cycloplegia and effective pupil dilation for completion of a pediatric eye examination. One drop is easier to instill than multiple drops and should be considered for use in a pediatric eye examination.
The effect of phenylephrine and cyclopentolate on objective wavefront measurements. [2006.05]
PURPOSE: To investigate the impact of phenylephrine and cyclopentolate on wavefront refraction and fourth order spherical aberration C12... CONCLUSIONS: Fogging of the accommodation target should be used for wavefront measurements. Weaker cycloplegic agents, such as tropicamide, may be used to ensure relaxed but not completely paralyzed accommodation, which would yield "manifest" aberration values close to the natural resting state.
Clinical Trials Related to Cyclomydril (Cyclopentolate / Phenylephrine Ophthalmic)
Spectral Domain Optical Coherence Tomography Imaging of the Eyes of Neonates [Recruiting]
The purpose of this study is to better characterize the retina and optic nerve in newborns
using spectral domain optical coherence tomography (s-oct). This new technology provides a
very detailed cross-section picture of the cellular layers in the retina and a 3-dimensional
picture of the optic nerve head and the fovea (the center of the retina that provides the
most accurate vision). These images have been used by doctors for more than 5 years to help
diagnose and treat adults with eye diseases, such as macular degeneration, diabetic
retinopathy, retinal detachments, and melanoma. But, it has never been studied in newborns.
In newborns, it would potentially help in the diagnoses of glaucoma, optic nerve
hypoplasia, foveal hypoplasia, and colobomata among many other disorders. Prior to
diagnosing disorders, it is necessary to establish normal values. It is the purpose of this
investigation to study the retina and optic nerves in neonates to establish normal values.
After a parent of a normal newborn provides a written consent, the baby will be taken to the
Eye Clinic where the instrument is located. The baby will be swaddled in one or more
blankets as needed. The infants will be held in front of the instrument by a nurse. The
technician will move the lens of the instrument to about 2 to 4 inches from the baby's eye.
The mild light from the instrument will then enter the eye for a few seconds to obtain the
desired image. The image can be captured through an immobile eye within 5 seconds. If the
baby is fussy, he or she may be given a few drops of a sugar (sucrose) solution on a
pacifier for calming. Although the images can usually be secured through a normal pupil, if
the pupil is found to be too small, two drops of Cyclomydril will be placed on the eye for
dilation. This is the eye drop used everyday in the Eye Clinic and nursery to dilate the
pupils of babies. The dilation will last for about 6 to 10 hours. After the test, the baby
will return to the nursery or be discharged home as intended by the Neonatology Division.
There is minimal risk associated with this investigation. The instrument is non-invasive
and does not touch the eye. The babies will be swaddled and held by a nurse to prevent any
contact with the machine. The eye drop to be used if needed for dilation has been used on
babies at Harbor for about 30 years. It has been found to very safe. The fact that we will
study only term (not premature babies) and will apply only two drops if needed should
minimize any risk from the eye drop.
An ethical issue to consider is that while the study will provide important information that
will undoubtedly help babies in the future, it will probably not benefit the baby being
studied. However, if the baby has an undetected retinal or optic nerve problem, the study
may reveal it.
Does Undercorrection of Myopia Retard Myopia Progression Among Kindergarten Children? [Recruiting]
The purpose of this study is to find out if undercorrection of myopia slow down the
progression of myopia in kindergarten children.