Cyclogyl (Cyclopentolate Hydrochloride Ophthalmic) - Summary

CYCLOGYL SUMMARY

CYCLOGYL® (cyclopentolate hydrochloride ophthalmic solution,USP) is an anticholinergic prepared as a sterile, borate buffered, solution for topical ocular use.

Cyclogyl (cyclopentolate OPHTHALMIC) is indicated for the following:

Cyclopentolate hydrochloride is used to produce mydriasis and cycloplegia.

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NEWS HIGHLIGHTS

Published Studies Related to Cyclogyl (Cyclopentolate Ophthalmic)

Preoperative topical cyclopentolate can be omitted when using intracameral lidocaine in phacoemulsification surgery. [2009.05]
PURPOSE: To evaluate the mydriatic effect of topical cyclopentolate 1% when combined with topical phenylephrine 10% and intracameral lidocaine 1% in phacoemulsification cataract surgery... CONCLUSIONS: Preoperative topical cyclopentolate does not enhance mydriasis in phacoemulsification surgery when using intracameral lidocaine and can be omitted when intracameral lidocaine is used.

Separate and additive mydriatic effects of lidocaine hydrochloride, phenylephrine, and cyclopentolate after intracameral injection. [2008.02]
PURPOSE: To assess the separate mydriatic effect of lidocaine hydrochloride (Xylocaine), cyclopentolate, and phenylephrine after intracameral injection and evaluate whether intracameral Xylocaine and phenylephrine without cyclopentolate provide sufficient pupil dilation for cataract surgery. SETTING: Department of Clinical Science/Ophthalmology, Umea University Hospital, Umea, Sweden... CONCLUSIONS: Xylocaine plus phenylephrine injected intracamerally gave adequate intraoperative pupil dilation in routine phacoemulsification surgery. Cyclopentolate administrated intracamerally had no immediate additive mydriatic effect to intracameral Xylocaine combined with phenylephrine.

[Influence of the instillation of two versus three eyedrops of cyclopentolate 0.5% on refraction of Caucasian nonstrabismic children] [2008.01]
INTRODUCTION: Children's refraction can usually be measured using cyclopentolate 0.5%. Instilling three drops is time-consuming and inconvenient to both the clinical staff and the child. To remedy this situation, we investigated the refractive results of instilling two drops of cyclopentolate 0.5% at a 10-min interval compared with three drops at a 5-min interval in a group of a Caucasian nonstrabismic children. The kinetics of refraction in this population was also assessed... CONCLUSION: Instilling two eyedrops of cyclopentolate 0.5% at a 10-min interval in Caucasian nonstrabismic children aged 4-13 years is as effective as instilling three eyedrops at a 5-min interval in terms of kinetics and depth of cycloplegia. In addition, skiascopy can be performed as early as 30 min after the first instillation and until the 90th minute with the same effectiveness. The stability of astigmatism should be underlined in this population. Since these refractive results cannot be extrapolated for strabismic and ametropic children, we recommend, especially for the latter, instilling three drops for the first exam and only two thereafter, depending on the results.

Optimal dosage of cyclopentolate 1% for complete cycloplegia: A randomized clinical trial. [2007.05]
PURPOSE. To determine the optimal dosage of cyclopentolate for adequate cycloplegia with minimal side effects.There were less frequent side effects using one drop of cyclopentolate, compared to two or three drops.

Comparison of tropicamide and cyclopentolate for cycloplegic refractions in myopic adult refractive surgery patients. [2005.04]
PURPOSE: To compare tropicamide 1%, a shorter-acting cycloplegic agent, with cyclopentolate 1% for cycloplegic refractions in adult refractive surgery patients. SETTING: Navy Refractive Surgery Center, Ophthalmology, Naval Medical Center, San Diego, California... CONCLUSIONS: There was no statistically significant difference in mean cycloplegic refractions. Cyclopentolate was more effective than tropicamide in reducing accommodative amplitude in adult myopes (near-point testing). Patients strongly preferred tropicamide.

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Clinical Trials Related to Cyclogyl (Cyclopentolate Ophthalmic)

Does Undercorrection of Myopia Retard Myopia Progression Among Kindergarten Children? [Recruiting]
The purpose of this study is to find out if undercorrection of myopia slow down the progression of myopia in kindergarten children.

The Pathophysiology of Orthostatic Hypotension [Recruiting]
The purpose of this study is to determine the cause of low blood pressure in selective patients who have problems with their involuntary (autonomic) nervous system. These patients frequently have had symptoms throughout their life, and their disorder might have a genetic basis. The biochemical, physiological and pharmacological procedures in this study should help us define the problem and perhaps lead to more effective treatment.

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Reports of Suspected Cyclogyl (Cyclopentolate Ophthalmic) Side Effects

Toxic Anterior Segment Syndrome (4),  Post Procedural Complication (2),  Cardiac Failure (2),  Body Temperature Increased (1),  Tachycardia (1),  Erythema (1),  Medication Error (1),  Abnormal Sleep-Related Event (1),  Rash (1),  Cerebrovascular Accident (1), more >>