CLINICAL PHARMACOLOGY
Pharmacokinetics
Absorption:
Indinavir was rapidly absorbed in the fasted state with a time to peak plasma concentration (Tmax) of 0.8 ± 0.3 hours (mean ± S.D.) (n=11). A greater than dose-proportional increase in indinavir plasma concentrations was observed over the 200-1000 mg dose range. At a dosing regimen of 800 mg every 8 hours, steady-state area under the plasma concentration time curve (AUC) was 30,691 ± 11,407 nM•hour (n=16), peak plasma concentration (Cmax) was 12,617 ± 4037 nM (n=16), and plasma concentration eight hours post dose (trough) was 251 ± 178 nM (n=16).
Effect of Food on Oral Absorption:
Administration of indinavir with a meal high in calories, fat, and protein (784 kcal, 48.6 g fat, 31.3 g protein) resulted in a 77% ± 8% reduction in AUC and an 84% ± 7% reduction in Cmax (n=10). Administration with lighter meals (e.g., a meal of dry toast with jelly, apple juice, and coffee with skim milk and sugar or a meal of corn flakes, skim milk and sugar) resulted in little or no change in AUC, Cmax or trough concentration.
Distribution:
Indinavir was approximately 60% bound to human plasma proteins over a concentration range of 81 nM to 16,300 nM.
Metabolism:
Following a 400-mg dose of 14C-indinavir, 83 ± 1% (n=4) and 19 ± 3% (n=6) of the total radioactivity was recovered in feces and urine, respectively; radioactivity due to parent drug in feces and urine was 19.1% and 9.4%, respectively. Seven metabolites have been identified, one glucuronide conjugate and six oxidative metabolites. In vitro studies indicate that cytochrome P-450 3A4 (CYP3A4) is the major enzyme responsible for formation of the oxidative metabolites.
Elimination:
Less than 20% of indinavir is excreted unchanged in the urine. Mean urinary excretion of unchanged drug was 10.4 ± 4.9% (n=10) and 12.0 ± 4.9% (n=10) following a single 700-mg and 1000-mg dose, respectively. Indinavir was rapidly eliminated with a half-life of 1.8 ± 0.4 hours (n=10). Significant accumulation was not observed after multiple dosing at 800 mg every 8 hours.
Special Populations
Hepatic Insufficiency:
Patients with mild to moderate hepatic insufficiency and clinical evidence of cirrhosis had evidence of decreased metabolism of indinavir resulting in approximately 60% higher mean AUC following a single 400-mg dose (n=12). The half-life of indinavir increased to 2.8 ± 0.5 hours. Indinavir pharmacokinetics have not been studied in patients with severe hepatic insufficiency (see DOSAGE AND ADMINISTRATION, Hepatic Insufficiency).
Renal Insufficiency:
The pharmacokinetics of indinavir have not been studied in patients with renal insufficiency.
Gender:
The effect of gender on the pharmacokinetics of indinavir was evaluated in 10 HIV seropositive women who received CRIXIVAN 800 mg every 8 hours with zidovudine 200 mg every 8 hours and lamivudine 150 mg twice a day for one week. Indinavir pharmacokinetic parameters in these women were compared to those in HIV seropositive men (pooled historical control data). Differences in indinavir exposure, peak concentrations, and trough concentrations between males and females are shown in Table 1 below:
Table 1 | PK Parameter | % change in PK parameter for females
relative to males | 90% Confidence Interval |
| ↓ Indicates a decrease in the PK parameter; ↑ Indicates an increase in the PK parameter. |
| | |
| AUC0-8h (nM•hr) | ↓13% | (↓32%, ↑12%) |
| | |
| Cmax (nM) | ↓13% | (↓32%, ↑10%) |
| | |
| C8h (nM) | ↓22% | (↓47%, ↑15%) |
The clinical significance of these gender differences in the pharmacokinetics of indinavir is not known.
Race:
Pharmacokinetics of indinavir appear to be comparable in Caucasians and Blacks based on pharmacokinetic studies including 42 Caucasians (26 HIV-positive) and 16 Blacks (4 HIV-positive).
Pediatric:
The optimal dosing regimen for use of indinavir in pediatric patients has not been established. In HIV-infected pediatric patients (age 4-15 years), a dosage regimen of indinavir capsules, 500 mg/m2 every 8 hours, produced AUC0-8hr of 38,742 ± 24,098 nM•hour (n=34), Cmax of 17,181 ± 9809 nM (n=34), and trough concentrations of 134 ± 91 nM (n=28). The pharmacokinetic profiles of indinavir in pediatric patients were not comparable to profiles previously observed in HIV-infected adults receiving the recommended dose of 800 mg every 8 hours. The AUC and Cmax values were slightly higher and the trough concentrations were considerably lower in pediatric patients. Approximately 50% of the pediatric patients had trough values below 100 nM; whereas, approximately 10% of adult patients had trough levels below 100 nM. The relationship between specific trough values and inhibition of HIV replication has not been established.
Pregnant Patients:
The optimal dosing regimen for use of indinavir in pregnant patients has not been established. A CRIXIVAN dose of 800 mg every 8 hours (with zidovudine 200 mg every 8 hours and lamivudine 150 mg twice a day) has been studied in 16 HIV-infected pregnant patients at 14 to 28 weeks of gestation at enrollment (study PACTG 358). The mean indinavir plasma AUC0-8hr at weeks 30-32 of gestation (n=11) was 9231 nM•hr, which is 74% (95% CI: 50%, 86%) lower than that observed 6 weeks postpartum. Six of these 11 (55%) patients had mean indinavir plasma concentrations 8 hours post-dose (Cmin) below assay threshold of reliable quantification. The pharmacokinetics of indinavir in these 11 patients at 6 weeks postpartum were generally similar to those observed in non-pregnant patients in another study (see PRECAUTIONS, Pregnancy).
Drug Interactions:
(also see CONTRAINDICATIONS, WARNINGS, PRECAUTIONS, Drug Interactions)
Indinavir is an inhibitor of the cytochrome P450 isoform CYP3A4. Coadministration of CRIXIVAN and drugs primarily metabolized by CYP3A4 may result in increased plasma concentrations of the other drug, which could increase or prolong its therapeutic and adverse effects (see CONTRAINDICATIONS and WARNINGS). Based on in vitro data in human liver microsomes, indinavir does not inhibit CYP1A2, CYP2C9, CYP2E1 and CYP2B6. However, indinavir may be a weak inhibitor of CYP2D6.
Indinavir is metabolized by CYP3A4. Drugs that induce CYP3A4 activity would be expected to increase the clearance of indinavir, resulting in lowered plasma concentrations of indinavir. Coadministration of CRIXIVAN and other drugs that inhibit CYP3A4 may decrease the clearance of indinavir and may result in increased plasma concentrations of indinavir.
Drug interaction studies were performed with CRIXIVAN and other drugs likely to be coadministered and some drugs commonly used as probes for pharmacokinetic interactions. The effects of coadministration of CRIXIVAN on the AUC, Cmax and Cmin are summarized in Table 2 (effect of other drugs on indinavir) and Table 3 (effect of indinavir on other drugs). For information regarding clinical recommendations, see Table 9 in PRECAUTIONS.
Table 2: Drug Interactions: Pharmacokinetic Parameters for Indinavir in the Presence of the Coadministered Drug (See PRECAUTIONS, Table 9 for Recommended Alterations in Dose or Regimen) | All interaction studies conducted in healthy, HIV-negative adult subjects, unless otherwise indicated. |
| | | | | | |
| Coadministered drug | Dose of Coadministered drug (mg) | Dose of CRIXIVAN (mg) | n | Ratio (with/without coadministered drug) of Indinavir
Pharmacokinetic Parameters
(90% CI); No Effect =1.00 |
| | | | Cmax | AUC | Cmin |
| Cimetidine | 600 twice daily,
6 days | 400 single dose | 12 | 1.07
(0.77, 1.49) | 0.98
(0.81, 1.19) | 0.82
(0.69, 0.99) |
| | | | | | |
| Clarithromycin | 500 q12h,
7 days | 800 three times daily, 7 days | 10 | 1.08
(0.85, 1.38) | 1.19
(1.00, 1.42) | 1.57
(1.16, 2.12) |
| | | | | | |
| Delavirdine | 400 three times daily | 400 three times daily, 7 days | 28 | 0.64
(0.48, 0.86) | No significant change | 2.18
(1.16, 4.12) |
| | | | | | |
| Delavirdine | 400 three times daily | 600 three times daily, 7 days | 28 | No significant change | 1.53
(1.07, 2.20) | 3.98
(2.04, 7.78) |
| | | | | | |
| Efavirenz
| 600 once daily,
10 days | 1000 three times daily, 10 days | 20 | | | |
| | | | | | |
| | After morning dose | | No significant change | 0.67
(0.61, 0.74) | 0.61
(0.49, 0.76) |
| | After afternoon dose | | No significant change | 0.63
(0.54, 0.74) | 0.48
(0.43, 0.53) |
| | After evening dose | | 0.71
(0.57, 0.89) | 0.54
(0.46, 0.63) | 0.43
(0.37, 0.50) |
| | | | | | |
| Fluconazole | 400 once daily,
8 days | 1000 three times daily, 7 days | 11 | 0.87
(0.72, 1.05) | 0.76
(0.59, 0.98) | 0.90
(0.72, 1.12) |
| | | | | | |
| Grapefruit Juice | 8 oz. | 400 single dose | 10 | 0.65
(0.53, 0.79) | 0.73
(0.60, 0.87) | 0.90
(0.71, 1.15) |
| | | | | | |
| Isoniazid | 300 once daily in the morning,
8 days | 800 three times daily, 7 days | 11 | 0.95
(0.88, 1.03) | 0.99
(0.87, 1.13) | 0.89
(0.75, 1.06) |
| | | | | | |
| Itraconazole | 200 twice daily,
7 days | 600 three times daily, 7 days | 12 | 0.78
(0.69, 0.88) | 0.99
(0.91, 1.06) | 1.49
(1.28, 1.74) |
| | | | | | |
| Ketoconazole | 400 once daily,
7 days | 600 three times daily, 7 days | 10 | 1.14
(0.93, 1.40) | 1.62
(1.38, 1.92) | 2.80
(2.20, 3.57) |
| | | | | | |
| Methadone | 20-60 once daily in the morning,
8 days | 800 three times daily, 8 days | 10 | See text below for discussion of interaction. |
| | | | | | |
| Quinidine | 200 single dose | 400 single dose | 10 | 0.96
(0.79, 1.18) | 1.07
(0.89, 1.28) | 0.93
(0.73, 1.19) |
| | | | | | |
| Rifabutin | 150 once daily in the morning,
10 days | 800 three times daily, 10 days | 14 | 0.80
(0.72, 0.89) | 0.68
(0.60, 0.76) | 0.60
(0.51, 0.72) |
| | | | | | |
| Rifabutin | 300 once daily in the morning,
10 days | 800 three times daily, 10 days | 10 | 0.75
(0.61, 0.91) | 0.66
(0.56, 0.77) | 0.61
(0.50, 0.75) |
| | | | | | |
| Rifampin | 600 once daily in the morning,
8 days | 800 three times daily, 7 days | 12 | 0.13
(0.08, 0.22) | 0.08
(0.06, 0.11) | Not Done |
| | | | | | |
| Ritonavir | 100 twice daily,
14 days | 800 twice daily,
14 days | 10, 16 | See text below for discussion of interaction. |
| | | | | | |
| Ritonavir | 200 twice daily,
14 days | 800 twice daily,
14 days | 9, 16 | See text below for discussion of interaction. |
| | | | | | |
| Sildenafil | 25 single dose | 800 three times daily | 6 | See text below for discussion of interaction. |
| | | | | | |
St. John's wort
(Hypericum perforatum,
standardized to 0.3 % hypericin) | 300 three times daily with meals,
14 days | 800 three times daily | 8 | Not Available | 0.46
(0.34, 0.58)
| 0.19
(0.06, 0.33) |
| | | | | | |
| Stavudine (d4T) | 40 twice daily,
7 days | 800 three times daily, 7 days | 11 | 0.95
(0.80, 1.11) | 0.95
(0.80, 1.12) | 1.13
(0.83, 1.53) |
| | | | | | |
Trimethoprim/
Sulfamethoxazole | 800 Trimethoprim/
160 Sulfamethoxazole q12h, 7 days | 400 four times daily, 7 days | 12 | 1.12
(0.87, 1.46) | 0.98
(0.81, 1.18) | 0.83
(0.72, 0.95) |
| | | | | | |
| Zidovudine | 200 three times daily, 7 days | 1000 three times daily, 7 days | 12 | 1.06
(0.91, 1.25) | 1.05
(0.86, 1.28) | 1.02
(0.77, 1.35) |
| | | | | | |
Zidovudine/
Lamivudine
(3TC) | 200/150 three times daily,
7 days | 800 three times daily, 7 days | 6, 9
| 1.05
(0.83, 1.33) | 1.04
(0.67, 1.61) | 0.98
(0.56, 1.73) |
Table 3: Drug Interactions: Pharmacokinetic Parameters for Coadministered Drug in the Presence of Indinavir (See PRECAUTIONS, Table 9 for Recommended Alterations in Dose or Regimen) | All interaction studies conducted in healthy, HIV-negative adult subjects, unless otherwise indicated. |
| Coadministered drug | Dose of Coadministered drug (mg) | Dose of CRIXIVAN (mg) | n | Ratio (with/without CRIXIVAN) of Coadministered Drug
Pharmacokinetic Parameters
(90% CI); No Effect =1.00 |
| | | | Cmax | AUC | Cmin |
| | | | | | |
| Clarithromycin | 500 twice daily,
7 days | 800 three times daily, 7 days | 12 | 1.19
(1.02, 1.39) | 1.47
(1.30, 1.65) | 1.97
(1.58, 2.46)
n=11 |
| | | | | | |
| Efavirenz | 200 once daily,
14 days | 800 three times daily, 14 days | 20 | No significant change | No significant change | -- |
| | | | | | |
Ethinyl Estradiol
(ORTHO-NOVUM 1/35)
| 35 mcg, 8 days | 800 three times daily, 8 days | 18 | 1.02
(0.96, 1.09) | 1.22
(1.15, 1.30) | 1.37
(1.24, 1.51) |
| | | | | | |
| Isoniazid | 300 once daily in the morning,
8 days | 800 three times daily, 8 days | 11 | 1.34
(1.12, 1.60) | 1.12
(1.03, 1.22) | 1.00
(0.92, 1.08) |
| | | | | | |
| Methadone
| 20-60 once daily in the morning,
8 days | 800 three times daily, 8 days | 12 | 0.93
(0.84, 1.03) | 0.96
(0.86, 1.06) | 1.06
(0.94, 1.19) |
| | | | | | |
Norethindrone
(ORTHO-NOVUM 1/35) | 1 mcg, 8 days | 800 three times daily, 8 days | 18 | 1.05
(0.95, 1.16) | 1.26
(1.20, 1.31) | 1.44
(1.32, 1.57) |
| | | | | | |
Rifabutin
•150 mg once daily in the morning, 11 days + indinavir compared to 300 mg once daily in the morning, 11 days alone | 150 once daily in the morning,
10 days
300 once daily in the morning,
10 days | 800 three times daily, 10 days
800 three times daily, 10 days | 14
10 | 1.29
(1.05, 1.59)
2.34
(1.64, 3.35) | 1.54
(1.33, 1.79)
2.73
(1.99, 3.77) | 1.99
(1.71, 2.31)
n=13
3.44
(2.65, 4.46)
n=9 |
| | | | | | |
| Ritonavir | 100 twice daily,
14 days | 800 twice daily,
14 days | 10, 4
| 1.61
(1.13, 2.29) | 1.72
(1.20, 2.48) | 1.62
(0.93, 2.85) |
| 200 twice daily,
14 days | 800 twice daily,
14 days | 9, 5 | 1.19
(0.85, 1.66) | 1.96
(1.39, 2.76) | 4.71
(2.66, 8.33)
n=9, 4 |
| | | | | | |
| Saquinavir | | | | | | |
| Hard gel formulation | 600 single dose | 800 three times daily, 2 days | 6 | 4.7
(2.7, 8.1) | 6.0
(4.0, 9.1) | 2.9
(1.7, 4.7)
|
| Soft gel formulation | 800 single dose | 800 three times daily, 2 days | 6 | 6.5
(4.7, 9.1) | 7.2
(4.3, 11.9) | 5.5
(2.2, 14.1) |
| Soft gel formulation | 1200 single dose | 800 three times daily, 2 days | 6 | 4.0
(2.7, 5.9) | 4.6
(3.2, 6.7) | 5.5
(3.7, 8.3) |
| | | | | | |
| Sildenafil | 25 single dose | 800 three times daily | 6 | See text below for discussion of interaction. |
| | | | | | |
| Stavudine
| 40 twice daily,
7 days | 800 three times daily, 7 days | 13 | 0.86
(0.73, 1.03) | 1.21
(1.09, 1.33) | Not Done |
| | | | | | |
| Theophylline | 250 single dose (on Days 1 and 7) | 800 three times daily, 6 days (Days 2 to 7) | 12, 4 | 0.88
(0.76, 1.03) | 1.14
(1.04, 1.24) | 1.13
(0.86, 1.49)
n=7, 3 |
| | | | | | |
Trimethoprim/
Sulfamethoxazole | | | | | | |
| Trimethoprim | 800 Trimethoprim/
160 Sulfamethoxazole q12h, 7 days | 400 q6h, 7 days | 12 | 1.18
(1.05, 1.32) | 1.18
(1.05, 1.33) | 1.18
(1.00, 1.39) |
| | | | | | |
Trimethoprim/
Sulfamethoxazole | | | | | | |
| Sulfamethoxazole | 800 Trimethoprim/
160 Sulfamethoxazole q12h, 7 days | 400 q6h, 7 days | 12 | 1.01
(0.95, 1.08) | 1.05
(1.01, 1.09) | 1.05
(0.97, 1.14) |
| | | | | | |
| Vardenafil | 2.5 single dose | 800 three times daily | 18 | See text below for discussion of interaction. |
| | | | | | |
| Zidovudine | 200 three times daily, 7 days | 1000 three times daily, 7 days | 12 | 0.89
(0.73, 1.09) | 1.17
(1.07, 1.29) | 1.51
(0.71, 3.20)
n=4 |
| | | | | | |
Zidovudine/
Lamivudine | | | | | | |
| Zidovudine | 200/150 three times daily, 7 days | 800 three times daily, 7 days | 6, 7 | 1.23
(0.74, 2.03) | 1.39
(1.02, 1.89) | 1.08
(0.77, 1.50)
n=5, 5 |
| | | | | | |
Zidovudine/
Lamivudine | | | | | | |
| Lamivudine | 200/150 three times daily, 7 days | 800 three times daily, 7 days | 6, 7 | 0.73
(0.52, 1.02) | 0.91
(0.66, 1.26) | 0.88
(0.59, 1.33) |
Delavirdine: Delavirdine inhibits the metabolism of indinavir such that coadministration of 400-mg or 600-mg indinavir three times daily with 400-mg delavirdine three times daily alters indinavir AUC, Cmax and Cmin (see Table 2). Indinavir had no effect on delavirdine pharmacokinetics (see DOSAGE AND ADMINISTRATION, Concomitant Therapy, Delavirdine), based on a comparison to historical delavirdine pharmacokinetic data.
Methadone: Administration of indinavir (800 mg every 8 hours) with methadone (20 mg to 60 mg daily) for one week in subjects on methadone maintenance resulted in no change in methadone AUC. Based on a comparison to historical data, there was little or no change in indinavir AUC.
Ritonavir: Compared to historical data in patients who received indinavir 800 mg every 8 hours alone, twice-daily coadministration to volunteers of indinavir 800 mg and ritonavir with food for two weeks resulted in a 2.7-fold increase of indinavir AUC24h, a 1.6-fold increase in indinavir Cmax, and an 11-fold increase in indinavir Cmin for a 100-mg ritonavir dose and a 3.6-fold increase of indinavir AUC24h, a 1.8- fold increase in indinavir Cmax, and a 24-fold increase in indinavir Cmin for a 200-mg ritonavir dose. In the same study, twice-daily coadministration of indinavir (800 mg) and ritonavir (100 or 200 mg) resulted in ritonavir AUC24h increases versus the same doses of ritonavir alone (see Table 3).
Sildenafil: The results of one published study in HIV-infected men (n=6) indicated that coadministration of indinavir (800 mg every 8 hours chronically) with a single 25-mg dose of sildenafil resulted in an 11% increase in average AUC0-8hr of indinavir and a 48% increase in average indinavir peak concentration (Cmax) compared to 800 mg every 8 hours alone. Average sildenafil AUC was increased by 340% following coadministration of sildenafil and indinavir compared to historical data following administration of sildenafil alone (see WARNINGS, Drug Interactions and PRECAUTIONS, Drug Interactions).
Vardenafil: Indinavir (800 mg every 8 hours) coadministered with a single 10-mg dose of vardenafil resulted in a 16-fold increase in vardenafil AUC, a 7-fold increase in vardenafil Cmax, and a 2-fold increase in vardenafil half-life (see WARNINGS, Drug Interactions and PRECAUTIONS, Drug Interactions).
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