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Crestor (Rosuvastatin Calcium) - Summary



CRESTOR (rosuvastatin calcium) is a synthetic lipid-lowering agent for oral administration.

Hyperlipidemia and Mixed Dyslipidemia

CRESTOR is indicated as adjunctive therapy to diet to reduce elevated Total-C, LDL-C, ApoB, nonHDL?C, and triglycerides and to increase HDL?C in adult patients with primary hyperlipidemia or mixed dyslipidemia. Lipid-altering agents should be used in addition to a diet restricted in saturated fat and cholesterol when response to diet and nonpharmacological interventions alone has been inadequate.

Pediatric Patients 10 to 17 years of age with Heterozygous Familial Hypercholesterolemia (HeFH)

Adjunct to diet to reduce Total?C, LDL?C and ApoB levels in adolescent boys and girls, who are at least one year post-menarche, 10?17 years of age with heterozygous familial hypercholesterolemia if after an adequate trial of diet therapy the following findings are present: LDL?C > 190 mg/dL or > 160 mg/dL and there is a positive family history of premature cardiovascular disease (CVD) or two or more other CVD risk factors.


CRESTOR is indicated as adjunctive therapy to diet for the treatment of adult patients with hypertriglyceridemia.

Primary Dysbetalipoproteinemia (Type III Hyperlipoproteinemia)

CRESTOR is indicated as an adjunct to diet for the treatment of patients with primary dysbetalipoproteinemia (Type III Hyperlipoproteinemia).

Homozygous Familial Hypercholesterolemia

CRESTOR is indicated as adjunctive therapy to other lipid-lowering treatments (e.g., LDL apheresis) or alone if such treatments are unavailable to reduce LDL?C, Total?C, and ApoB in adult patients with homozygous familial hypercholesterolemia.

Slowing of the Progression of Atherosclerosis

CRESTOR is indicated as adjunctive therapy to diet to slow the progression of atherosclerosis in adult patients as part of a treatment strategy to lower Total?C and LDL?C to target levels.

Primary Prevention of Cardiovascular Disease

In individuals without clinically evident coronary heart disease but with an increased risk of cardiovascular disease based on age ≥ 50 years old in men and ≥ 60 years old in women, hsCRP ≥ 2 mg/L, and the presence of at least one additional cardiovascular disease risk factor such as hypertension, low HDL?C, smoking, or a family history of premature coronary heart disease, CRESTOR is indicated to:

  • reduce the risk of stroke •
  • reduce the risk of myocardial infarction •
  • reduce the risk of arterial revascularization procedures •
Limitations of Use

CRESTOR has not been studied in Fredrickson Type I and V dyslipidemias.

See all Crestor indications & dosage >>


Published Studies Related to Crestor (Rosuvastatin)

Efficacy of early intensive rosuvastatin therapy in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention (ROSEMARY Study). [2014]
The purpose of the study was to investigate whether early high-dose potent statin therapy in patients with ST elevation myocardial infarction undergoing primary percutaneous coronary intervention can reduce infarct size compared with conventional low-dose statin therapy... In conclusion, early high-dose rosuvastatin therapy in patients with ST elevation myocardial infarction undergoing primary percutaneous coronary intervention did not improve periprocedural myocardial perfusion or reduce infarct volume measured by MRI compared with the conventional low-dose rosuvastatin regimen.

Lipoprotein(a) concentrations, rosuvastatin therapy, and residual vascular risk: an analysis from the JUPITER Trial (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin). [2014]
CONCLUSION: Among white JUPITER participants treated with potent statin therapy,

Rationale and design of LAPLACE-2: a phase 3, randomized, double-blind, placebo- and ezetimibe-controlled trial evaluating the efficacy and safety of evolocumab in subjects with hypercholesterolemia on background statin therapy. [2014]
Low-density lipoprotein cholesterol (LDL-C) levels are significantly associated with atherosclerotic cardiovascular disease (ASCVD) risk, and studies using interventions that lower LDL-C levels have been shown to reduce the risk of ASCVD events and mortality... This study will also provide comparative efficacy, safety, and tolerability data between evolocumab and ezetimibe when added to background atorvastatin therapy.

The effect of rosuvastatin on inflammation, matrix turnover and left ventricular remodeling in dilated cardiomyopathy: a randomized, controlled trial. [2014]
reduce or even reverse left ventricular remodeling in dilated cardiomyopathy... CONCLUSION: Treatment with rosuvastatin does not improve left ventricular

A randomized, double-blind study of fenofibric acid plus rosuvastatin compared with rosuvastatin alone in stage 3 chronic kidney disease. [2013]
study drug washout... CONCLUSIONS: The data suggest that, after 16 weeks of therapy, FA + R has an

more studies >>

Clinical Trials Related to Crestor (Rosuvastatin)

The Effects of Rifampin on the Pharmacokinetics of Rosuvastatin [Recruiting]
The effect of transporter inhibition by rifampin on the pharmacokinetics of rosuvastatin will be studied in clinical trial in White and Asian healthy volunteers.

A Study to Assess the Effects of Multiple Doses of Fidaxomicin on a Single Dose of Rosuvastatin in Healthy Male Subjects [Completed]
This study will assess the effect of multiple doses of fidaxomicin on the single dose pharmacokinetics of rosuvastatin in healthy male subjects. Determine the safety and tolerability of multiple doses of fidaxomicin in the presence of a single dose of rosuvastatin in healthy male subjects. Also determine the pharmacokinetics of multiple doses of fidaxomicin and its metabolite OP-1118.

The Rosuvastatin In TrAnsplant Recipients Study [Completed]
Renal transplant recipients need life long immunosuppression and one of the new drugs is everolimus. Everolimus is a potent immunosuppressive drug and one of the main side-effects are increased blood cholesterol levels. Many renal transplant recipients are treated with a cholesterol lowering agent, mainly fluvastatin. Rosuvastatin is a new cholesterol lowering drug on the market with a potential higher cholesterol lowering potency. In the present study the investigators will examine the hypothesis that rosuvastatin reduce cholesterol levels more than fluvastatin in renal transplant patients.

The Pharmacokinetic Drug Interaction Between Rosuvastatin and Telmisartan/Amlodipine [Completed]
A randomized, open-label, multiple-dose, crossover study to investigate the pharmacokinetic drug interaction between rosuvastatin and telmisartan/amlodipine in healthy male volunteers

A Phase 1 Clinical Trial to Investigate Pharmacokinetics and Drug Interaction of Crestor and Glucodown OR SR in Healthy Volunteers [Completed]
This clinical trial is designed to compare the pharmacokinetic characteristics of combination and separate administration of Crestor(Rosuvastatin) and Glucodown(Metformin SR). Also investigate drug interaction between separate and combination administration. Total number of subjects is 36. 6 group(6 for 1 group), 3 period, consecutive 5 day administration, 10 days washout after 5th day of administration. All subjects take Crestor alone, Glucodown alone, Crestor+Glucodown combination during 3 each period.

more trials >>

Reports of Suspected Crestor (Rosuvastatin) Side Effects

Drug Dose Omission (607)Malaise (589)Myocardial Infarction (441)Myalgia (424)Blood Cholesterol Increased (409)Pain in Extremity (309)Pain (288)Cerebrovascular Accident (281)Diabetes Mellitus (255)Fall (243)more >>


Based on a total of 16 ratings/reviews, Crestor has an overall score of 6.56. The effectiveness score is 8.12 and the side effect score is 7.62. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.

Crestor review by 50 year old male patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
Treatment Info
Condition / reason:   hypercholesterolemia
Dosage & duration:   10 mg taken 1 po qd for the period of continuous
Other conditions:   none
Other drugs taken:   baby aspirin
Reported Results
Benefits:   much lower cholesterol
Side effects:   none
Comments:   Within 4 weeks of starting Crestor, my LDL cholesterol went from 169 to 65. That is drop of over 100! No side effects at all.


Crestor review by 45 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
Treatment Info
Condition / reason:   very high cholestrol level 9.1
Dosage & duration:   10mg taken 1 pill per day for the period of 1 yr & stopped for 6 mths,then tak' aga
Other conditions:   N/A
Other drugs taken:   health supplements
Reported Results
Benefits:   Stops the cholestrol level dramatically.
Side effects:   Once you take it, you cannot stop. I took the pill for one year. At that time my cholestrol level was pretty well controlled. It dropped from 8.6 to 5.1. I stopped the pills and the cholestrol level immediately rise even higher than before (9.1)
Comments:   One pill per day after meal.


Crestor review by 65 year old female patient

Overall rating:  
Effectiveness:   Ineffective
Side effects:   Severe Side Effects
Treatment Info
Condition / reason:   High Cholesterol
Dosage & duration:   20 milligrams? not sure (dosage frequency: daily) for the period of 6 months
Other conditions:   None
Other drugs taken:   Miacalcin
Reported Results
Benefits:   None
Side effects:   Over a period of several months, I got to a point where I ached so much in the morning that I could hardly get out of bed, I could control the pain with OTC painkillers. I had been able to carry a 40 pound bag of dog food easily, I got so that I could barely carry five pounds of groceries. I felt that I had aged about twenty years in a few months!
Comments:   I lucked out finding the answer in an online newsletter that warned Crestor users of this problem which the manufacturer claimed was "very rare". My doctor told me to stop it immediately, gradually I got better. I still cringe when I see Crestor advertised on TV or in a magazine...

See all Crestor reviews / ratings >>

Page last updated: 2015-08-10

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