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Crestor (Rosuvastatin Calcium) - Summary

 
 



CRESTOR SUMMARY

CRESTOR (rosuvastatin calcium) is a synthetic lipid-lowering agent for oral administration.

Hyperlipidemia and Mixed Dyslipidemia

CRESTOR is indicated as adjunctive therapy to diet to reduce elevated Total-C, LDL-C, ApoB, nonHDL?C, and triglycerides and to increase HDL?C in adult patients with primary hyperlipidemia or mixed dyslipidemia. Lipid-altering agents should be used in addition to a diet restricted in saturated fat and cholesterol when response to diet and nonpharmacological interventions alone has been inadequate.

Pediatric Patients 10 to 17 years of age with Heterozygous Familial Hypercholesterolemia (HeFH)

Adjunct to diet to reduce Total?C, LDL?C and ApoB levels in adolescent boys and girls, who are at least one year post-menarche, 10?17 years of age with heterozygous familial hypercholesterolemia if after an adequate trial of diet therapy the following findings are present: LDL?C > 190 mg/dL or > 160 mg/dL and there is a positive family history of premature cardiovascular disease (CVD) or two or more other CVD risk factors.

Hypertriglyceridemia

CRESTOR is indicated as adjunctive therapy to diet for the treatment of adult patients with hypertriglyceridemia.

Primary Dysbetalipoproteinemia (Type III Hyperlipoproteinemia)

CRESTOR is indicated as an adjunct to diet for the treatment of patients with primary dysbetalipoproteinemia (Type III Hyperlipoproteinemia).

Homozygous Familial Hypercholesterolemia

CRESTOR is indicated as adjunctive therapy to other lipid-lowering treatments (e.g., LDL apheresis) or alone if such treatments are unavailable to reduce LDL?C, Total?C, and ApoB in adult patients with homozygous familial hypercholesterolemia.

Slowing of the Progression of Atherosclerosis

CRESTOR is indicated as adjunctive therapy to diet to slow the progression of atherosclerosis in adult patients as part of a treatment strategy to lower Total?C and LDL?C to target levels.

Primary Prevention of Cardiovascular Disease

In individuals without clinically evident coronary heart disease but with an increased risk of cardiovascular disease based on age ≥ 50 years old in men and ≥ 60 years old in women, hsCRP ≥ 2 mg/L, and the presence of at least one additional cardiovascular disease risk factor such as hypertension, low HDL?C, smoking, or a family history of premature coronary heart disease, CRESTOR is indicated to:

  • reduce the risk of stroke •
  • reduce the risk of myocardial infarction •
  • reduce the risk of arterial revascularization procedures •
Limitations of Use

CRESTOR has not been studied in Fredrickson Type I and V dyslipidemias.


See all Crestor indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Crestor (Rosuvastatin)

Efficacy of early intensive rosuvastatin therapy in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention (ROSEMARY Study). [2014]
The purpose of the study was to investigate whether early high-dose potent statin therapy in patients with ST elevation myocardial infarction undergoing primary percutaneous coronary intervention can reduce infarct size compared with conventional low-dose statin therapy... In conclusion, early high-dose rosuvastatin therapy in patients with ST elevation myocardial infarction undergoing primary percutaneous coronary intervention did not improve periprocedural myocardial perfusion or reduce infarct volume measured by MRI compared with the conventional low-dose rosuvastatin regimen.

Lipoprotein(a) concentrations, rosuvastatin therapy, and residual vascular risk: an analysis from the JUPITER Trial (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin). [2014]
CONCLUSION: Among white JUPITER participants treated with potent statin therapy,

A randomized, double-blind study of fenofibric acid plus rosuvastatin compared with rosuvastatin alone in stage 3 chronic kidney disease. [2013]
study drug washout... CONCLUSIONS: The data suggest that, after 16 weeks of therapy, FA + R has an

Effect of rosuvastatin on ROCK activity, endothelial function, and inflammation in Asian patients with atherosclerosis. [2012]
lower cholesterol levels, inhibit ROCK activity in humans with atherosclerosis... CONCLUSION: These results demonstrate that high dose rosuvastatin exerts greater

The effect of rosuvastatin on incident pneumonia: results from the JUPITER trial. [2012]
rosuvastatin to examine this hypothesis... INTERPRETATION: Data from this randomized controlled trial support the hypothesis

more studies >>

Clinical Trials Related to Crestor (Rosuvastatin)

Compare the Safety & Efficacy of Rosuvastatin 40mg in Combination With Ezetimibe 10mg [Completed]
The purpose of this study is to compare 6 weeks of treatment with rosuvastatin alone compared with 6 weeks of treatment of rosuvastatin combined with ezetimibe in achieving low density lipoprotein level goals.

Assessment of Potential Interaction Between Ezetimibe and Rosuvastatin in Healthy Subjects With High Cholesterol (P03317)(COMPLETED) [Completed]
The purpose of this study is to obtain data of the coadministration of ezetimibe and rosuvastatin to support the concomitant use of these two drugs in patients requiring additional cholesterol-lowering management. Treatment is administered for 14 days.

Polaris - Crestor 40 mg vs Atorvastatin 80 mg for 26 Weeks [Completed]
The purpose of this study is to compare the effect of 8 weeks of treatment with Rosuvastatin with 8 weeks of treatment with Atorvastatin on low density lipoprotein cholesterol level in subjects with hypercholesterolemia and coronary heart disease (CHD) or at high risk of CHD..

Prospective Evaluation of Proteinuria and Renal Function in Diabetic Patients With Progressive Renal Disease [Active, not recruiting]
The purpose of this study is to evaluate the effects of Crestor (rosuvastatin) and (Lipitor) atorvastatin on urinary protein excretion over 1 year in patients with Type 1 or 2 diabetes with moderate proteinuria and hypercholesterolaemia.

Comparison of Rosuvastatin and Atorvastatin in Patients With Acute Coronary Syndrome [Completed]
This is a 3-month, randomized, parallel-group study with 2 periods, comparing the efficacy and the safety of rosuvastatin 20 mg versus atorvastatin 80 mg in patients with an acute coronary syndrome (ACS).

more trials >>

Reports of Suspected Crestor (Rosuvastatin) Side Effects

Drug Dose Omission (607)Malaise (589)Myocardial Infarction (441)Myalgia (424)Blood Cholesterol Increased (409)Pain in Extremity (309)Pain (288)Cerebrovascular Accident (281)Diabetes Mellitus (255)Fall (243)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 16 ratings/reviews, Crestor has an overall score of 6.56. The effectiveness score is 8.12 and the side effect score is 7.62. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Crestor review by 50 year old male patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   hypercholesterolemia
Dosage & duration:   10 mg taken 1 po qd for the period of continuous
Other conditions:   none
Other drugs taken:   baby aspirin
  
Reported Results
Benefits:   much lower cholesterol
Side effects:   none
Comments:   Within 4 weeks of starting Crestor, my LDL cholesterol went from 169 to 65. That is drop of over 100! No side effects at all.

 

Crestor review by 45 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   very high cholestrol level 9.1
Dosage & duration:   10mg taken 1 pill per day for the period of 1 yr & stopped for 6 mths,then tak' aga
Other conditions:   N/A
Other drugs taken:   health supplements
  
Reported Results
Benefits:   Stops the cholestrol level dramatically.
Side effects:   Once you take it, you cannot stop. I took the pill for one year. At that time my cholestrol level was pretty well controlled. It dropped from 8.6 to 5.1. I stopped the pills and the cholestrol level immediately rise even higher than before (9.1)
Comments:   One pill per day after meal.

 

Crestor review by 65 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   High Cholesterol
Dosage & duration:   20 milligrams? not sure (dosage frequency: daily) for the period of 6 months
Other conditions:   None
Other drugs taken:   Miacalcin
  
Reported Results
Benefits:   None
Side effects:   Over a period of several months, I got to a point where I ached so much in the morning that I could hardly get out of bed, I could control the pain with OTC painkillers. I had been able to carry a 40 pound bag of dog food easily, I got so that I could barely carry five pounds of groceries. I felt that I had aged about twenty years in a few months!
Comments:   I lucked out finding the answer in an online newsletter that warned Crestor users of this problem which the manufacturer claimed was "very rare". My doctor told me to stop it immediately, gradually I got better. I still cringe when I see Crestor advertised on TV or in a magazine...

See all Crestor reviews / ratings >>

Page last updated: 2014-11-30

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