CRESTOR SUMMARY
CRESTOR® (rosuvastatin calcium) is a synthetic lipid-lowering agent. Rosuvastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol biosynthesis.
CRESTOR is indicated:
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as an adjunct to diet to reduce elevated total-C, LDL-C, ApoB, nonHDL-C, and TG levels and to increase HDL-C in patients with primary hypercholesterolemia (heterozygous familial and nonfamilial) and mixed dyslipidemia (Fredrickson Type IIa and IIb);
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as an adjunct to diet for the treatment of patients with elevated serum TG levels (Fredrickson Type IV);
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to reduce LDL-C, total-C, and ApoB in patients with homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable.
According to NCEP-ATPIII guidelines, therapy with lipid-altering agents should be a component of multiple-risk-factor intervention in individuals at increased risk for coronary heart disease due to hypercholesterolemia. The two major modalities of LDL-lowering therapy are therapeutic lifestyle changes (TLC) and drug therapy. The TLC Diet stresses reductions in saturated fat and cholesterol intake.
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NEWS HIGHLIGHTSMedia Articles Related to Crestor (Rosuvastatin)
Crestor® Reduced Risk Of Cardiovascular Events In Women By Nearly Half In New Analysis Of Jupiter Study
Source: Cardiovascular / Cardiology News From Medical News Today [2009.11.19]
A new analysis of 6,801 women in the JUPITER study showed CRESTOR® (rosuvastatin calcium) 20 mg significantly reduced cardiovascular (CV) events (defined as the combined risk of myocardial infarction, stroke, arterial revascularization, hospitalization for unstable angina, or death from CV causes) by nearly half (46 percent; p=0.002 vs.
Crestor shows equal or better benefit to women (Reuters)
Source: Y! Health Cholesterol News [2009.11.17]
Reuters - A fresh look at data from a landmark study showed that AstraZeneca's powerful cholesterol fighter Crestor dramatically cut deaths, heart attacks and strokes in women at least as much as in men, providing new evidence of the drug's benefits in a previously understudied population.
AHA: Drilling Down in JUPITER Confirms Benefit for Women (CME/CE)
Source: MedPageToday.com - medical news plus CME for physicians [2009.11.19]
ORLANDO (MedPage Today) -- A subset analysis of data from the JUPITER trial indicates that apparently healthy women treated with rosuvastatin (Crestor) reduced their relative risk of major cardiovascular events by 46%, slightly higher than the 42% reduction seen in men.
Published Studies Related to Crestor (Rosuvastatin)
Effects of rosuvastatin on atrial fibrillation occurrence: ancillary results of the GISSI-HF trial. [2009.10]
CONCLUSION: This study shows that there is some evidence of a beneficial effect of rosuvastatin in terms of reduction of AF occurrence in patients with HF. Larger populations are needed to provide a definite answer to the question. ClinicalTrials.gov Identifier: NCT00336336.
A randomized, controlled trial of simvastatin versus rosuvastatin in patients with acute myocardial infarction: the Secondary Prevention of Acute Coronary Events - Reduction of Cholesterol to Key European Targets Trial. [2009.09.09]
CONCLUSION: We observed no superiority of either treatment for the ESC-03 lipid targets. Rosuvastatin 10 mg lowered mean cholesterol more effectively than simvastatin and achieved better results for the latest, more stringent, ESC target.
Effect of n-3 polyunsaturated fatty acids and rosuvastatin in patients with heart failure: results of the GISSI-HF trial. [2009.07]
Epidemiological, experimental studies and post hoc analyses of randomized trials suggested that n-3 polyunsaturated fatty acids (PUFA) and statins could be beneficial in chronic heart failure. Two double-blind, placebo-controlled, randomized clinical trials investigated the efficacy and safety of n-3 PUFA 1 g daily (R1) and rosuvastatin 10 mg daily (R2) in patients with heart failure...
Adding exercise training to rosuvastatin treatment: influence on serum lipids and biomarkers of muscle and liver damage. [2009.07]
Statin treatment and exercise training can improve lipid profile when administered separately... There was no abnormal sustained increase in CK or reports of myalgia after the addition of exercise training to rosuvastatin treatment.
Rosuvastatin increases extracellular adenosine formation in humans in vivo: a new perspective on cardiovascular protection. [2009.06]
CONCLUSIONS: Rosuvastatin increases extracellular adenosine formation, which provides protection against ischemia-reperfusion injury in humans in vivo. Therefore, statins and dipyridamole may interact synergistically.
Clinical Trials Related to Crestor (Rosuvastatin)
Compare the Safety & Efficacy of Rosuvastatin 40mg in Combination With Ezetimibe 10mg [Completed]
The purpose of this study is to compare 6 weeks of treatment with rosuvastatin alone compared
with 6 weeks of treatment of rosuvastatin combined with ezetimibe in achieving low density
lipoprotein level goals.
Assessment of Potential Interaction Between Ezetimibe and Rosuvastatin in Healthy Subjects With High Cholesterol (P03317)(COMPLETED) [Completed]
The purpose of this study is to obtain data of the coadministration of ezetimibe and
rosuvastatin to support the concomitant use of these two drugs in patients requiring
additional cholesterol-lowering management. Treatment is administered for 14 days.
Polaris - Crestor 40 mg vs Atorvastatin 80 mg for 26 Weeks [Completed]
The purpose of this study is to compare the effect of 8 weeks of treatment with Rosuvastatin
with 8 weeks of treatment with Atorvastatin on low density lipoprotein cholesterol level in
subjects with hypercholesterolemia and coronary heart disease (CHD) or at high risk of CHD..
Prospective Evaluation of Proteinuria and Renal Function in Diabetic Patients With Progressive Renal Disease [Active, not recruiting]
The purpose of this study is to evaluate the effects of Crestor (rosuvastatin) and (Lipitor)
atorvastatin on urinary protein excretion over 1 year in patients with Type 1 or 2 diabetes
with moderate proteinuria and hypercholesterolaemia.
Comparison of Rosuvastatin and Atorvastatin in Patients With Acute Coronary Syndrome [Completed]
This is a 3-month, randomized, parallel-group study with 2 periods, comparing the efficacy
and the safety of rosuvastatin 20 mg versus atorvastatin 80 mg in patients with an acute
coronary syndrome (ACS).
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 8 ratings/reviews, Crestor has an overall score of 9.50. The effectiveness score is 9.25 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Crestor review by 50 year old male patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | hypercholesterolemia |
| Dosage & duration: | | 10 mg taken 1 po qd for the period of continuous |
| Other conditions: | | none |
| Other drugs taken: | | baby aspirin | | |
Reported Results |
| Benefits: | | much lower cholesterol |
| Side effects: | | none |
| Comments: | | Within 4 weeks of starting Crestor, my LDL cholesterol went from 169 to 65. That is drop of over 100! No side effects at all. |
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| | Crestor review by 47 year old male patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | High Cholestrol |
| Dosage & duration: | | 1 pill per day taken daily for the period of 5 years |
| Other conditions: | | None |
| Other drugs taken: | | None | | |
Reported Results |
| Benefits: | | The treatment benefits were that my cholestrol levels went from 9 to the 4-5 level. This was demonstrated by regular blood test results. |
| Side effects: | | The only side effect occured in the first 3 months, where slight aching of the joints and muscles was experienced. This disappeared after 3 months. |
| Comments: | | A pill is taken every night before going to bed. |
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| | Crestor review by 57 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Moderately Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | high cholesterol |
| Dosage & duration: | | 40mg taken daily for the period of 6 months |
| Other conditions: | | hypertension, diabetes ll |
| Other drugs taken: | | micardis 40mg, diabex 500mg | | |
Reported Results |
| Benefits: | | lowered my cholesterol level over time; reduced the severity of dietary changes I needed to make for the same effect; reduced my anxiety about my potential risk of cardiac and cerebrovacular problems/events |
| Side effects: | | I have not noticed any side effects; I am aware of the potential side effects and alert to symptoms of same. |
| Comments: | | one tablet daily, no other sepcifications. I take all meds on retiring. I also take fish oil capsules. |
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Page last updated: 2009-11-19
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