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Crestor (Rosuvastatin Calcium) - Summary

 
 



CRESTOR SUMMARY

CRESTOR® (rosuvastatin calcium) is a synthetic lipid-lowering agent. Rosuvastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol biosynthesis.

CRESTOR is indicated:

  1. as an adjunct to diet to reduce elevated total-C, LDL-C, ApoB, nonHDL-C, and TG levels and to increase HDL-C in patients with primary hypercholesterolemia (heterozygous familial and nonfamilial) and mixed dyslipidemia (Fredrickson Type IIa and IIb);
  2. as an adjunct to diet for the treatment of patients with elevated serum TG levels (Fredrickson Type IV);
  3. to reduce LDL-C, total-C, and ApoB in patients with homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable.

According to NCEP-ATPIII guidelines, therapy with lipid-altering agents should be a component of multiple-risk-factor intervention in individuals at increased risk for coronary heart disease due to hypercholesterolemia. The two major modalities of LDL-lowering therapy are therapeutic lifestyle changes (TLC) and drug therapy. The TLC Diet stresses reductions in saturated fat and cholesterol intake.
See all Crestor indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Crestor (Rosuvastatin)

Crestor Tops List of Best-Selling Drugs
Source: MedicineNet rosuvastatin Specialty [2013.11.04]
Title: Crestor Tops List of Best-Selling Drugs
Category: Health News
Created: 11/2/2013 11:00:00 AM
Last Editorial Review: 11/4/2013 12:00:00 AM

Potent Statin Offers No Help After Cardiac Surgery
Source: MedPage Today Surgery [2014.09.04]
BARCELONA (MedPage Today) -- Rosuvastatin (Crestor) -- a potent lipid-lowering agent thought to inhibit inflammation as well -- failed to prevent postoperative cardiac surgery complications such as atrial fibrillation.

Statin standoff: Does rosuvastatin tip the balance in diabetic patients?
Source: Cholesterol News From Medical News Today [2014.09.02]
When it comes to cholesterol-lowering statin medications for patients with type 2 diabetes, rosuvastatin may be a better choice than atorvastatin, according to the findings of a new study presented...

more news >>

Published Studies Related to Crestor (Rosuvastatin)

Effect of rosuvastatin on ROCK activity, endothelial function, and inflammation in Asian patients with atherosclerosis. [2012]
lower cholesterol levels, inhibit ROCK activity in humans with atherosclerosis... CONCLUSION: These results demonstrate that high dose rosuvastatin exerts greater

The effect of rosuvastatin on incident pneumonia: results from the JUPITER trial. [2012]
rosuvastatin to examine this hypothesis... INTERPRETATION: Data from this randomized controlled trial support the hypothesis

Drug safety evaluation of rosuvastatin. [2011.11]
INTRODUCTION: Rosuvastatin is a highly efficacious statin approved for use throughout the world. Rosuvastatin has been exhaustively evaluated in the setting of a broad variety of dyslipidemias and cardiovascular disease states in clinical trials encompassed within the GALAXY program... Care must be taken to reduce the dose of rosuvastatin in patients of Asian ancestry or with stage IV chronic kidney disease (severe renal insufficiency), as well as patients being treated with protease inhibitors or cyclosporine.

Rationale and design of STOP DVT study: rosuvastatin for the prevention of deep vein thrombosis in patients undergoing total knee replacement arthroplasty--a prospective randomized open-label controlled trial. [2011.09]
BACKGROUND: Deep vein thrombosis (DVT) frequently occurs in high-risk cardiovascular patients receiving orthopedic surgery, despite prophylactic measures for its prevention. Statins, a class of drugs used to lower cholesterol levels, have been reported to help prevent the development of DVT...

Effects of rosuvastatin on subclinical atherosclerosis and arterial stiffness in rheumatoid arthritis: a randomized controlled pilot trial. [2011.08.26]
Objective: To ascertain the effect of rosuvastatin on carotid atherosclerosis and arterial stiffness in patients with rheumatoid arthritis (RA). Methods: Fifty RA patients were randomized in a double-blind placebo-controlled trial to receive 10 mg rosuvastatin (n = 24) or placebo (n = 26)... Rosuvastastin may also improve subendocardial perfusion and lower the urate level.

more studies >>

Clinical Trials Related to Crestor (Rosuvastatin)

Compare the Safety & Efficacy of Rosuvastatin 40mg in Combination With Ezetimibe 10mg [Completed]
The purpose of this study is to compare 6 weeks of treatment with rosuvastatin alone compared with 6 weeks of treatment of rosuvastatin combined with ezetimibe in achieving low density lipoprotein level goals.

Assessment of Potential Interaction Between Ezetimibe and Rosuvastatin in Healthy Subjects With High Cholesterol (P03317)(COMPLETED) [Completed]
The purpose of this study is to obtain data of the coadministration of ezetimibe and rosuvastatin to support the concomitant use of these two drugs in patients requiring additional cholesterol-lowering management. Treatment is administered for 14 days.

Polaris - Crestor 40 mg vs Atorvastatin 80 mg for 26 Weeks [Completed]
The purpose of this study is to compare the effect of 8 weeks of treatment with Rosuvastatin with 8 weeks of treatment with Atorvastatin on low density lipoprotein cholesterol level in subjects with hypercholesterolemia and coronary heart disease (CHD) or at high risk of CHD..

Prospective Evaluation of Proteinuria and Renal Function in Diabetic Patients With Progressive Renal Disease [Active, not recruiting]
The purpose of this study is to evaluate the effects of Crestor (rosuvastatin) and (Lipitor) atorvastatin on urinary protein excretion over 1 year in patients with Type 1 or 2 diabetes with moderate proteinuria and hypercholesterolaemia.

Comparison of Rosuvastatin and Atorvastatin in Patients With Acute Coronary Syndrome [Completed]
This is a 3-month, randomized, parallel-group study with 2 periods, comparing the efficacy and the safety of rosuvastatin 20 mg versus atorvastatin 80 mg in patients with an acute coronary syndrome (ACS).

more trials >>

Reports of Suspected Crestor (Rosuvastatin) Side Effects

Drug Dose Omission (607)Malaise (589)Myocardial Infarction (441)Myalgia (424)Blood Cholesterol Increased (409)Pain in Extremity (309)Pain (288)Cerebrovascular Accident (281)Diabetes Mellitus (255)Fall (243)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 16 ratings/reviews, Crestor has an overall score of 6.56. The effectiveness score is 8.12 and the side effect score is 7.62. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Crestor review by 50 year old male patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   hypercholesterolemia
Dosage & duration:   10 mg taken 1 po qd for the period of continuous
Other conditions:   none
Other drugs taken:   baby aspirin
  
Reported Results
Benefits:   much lower cholesterol
Side effects:   none
Comments:   Within 4 weeks of starting Crestor, my LDL cholesterol went from 169 to 65. That is drop of over 100! No side effects at all.

 

Crestor review by 45 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   very high cholestrol level 9.1
Dosage & duration:   10mg taken 1 pill per day for the period of 1 yr & stopped for 6 mths,then tak' aga
Other conditions:   N/A
Other drugs taken:   health supplements
  
Reported Results
Benefits:   Stops the cholestrol level dramatically.
Side effects:   Once you take it, you cannot stop. I took the pill for one year. At that time my cholestrol level was pretty well controlled. It dropped from 8.6 to 5.1. I stopped the pills and the cholestrol level immediately rise even higher than before (9.1)
Comments:   One pill per day after meal.

 

Crestor review by 65 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   High Cholesterol
Dosage & duration:   20 milligrams? not sure (dosage frequency: daily) for the period of 6 months
Other conditions:   None
Other drugs taken:   Miacalcin
  
Reported Results
Benefits:   None
Side effects:   Over a period of several months, I got to a point where I ached so much in the morning that I could hardly get out of bed, I could control the pain with OTC painkillers. I had been able to carry a 40 pound bag of dog food easily, I got so that I could barely carry five pounds of groceries. I felt that I had aged about twenty years in a few months!
Comments:   I lucked out finding the answer in an online newsletter that warned Crestor users of this problem which the manufacturer claimed was "very rare". My doctor told me to stop it immediately, gradually I got better. I still cringe when I see Crestor advertised on TV or in a magazine...

See all Crestor reviews / ratings >>

Page last updated: 2014-09-04

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