CRESTOR SUMMARY
CRESTOR® (rosuvastatin calcium) is a synthetic lipid-lowering agent. Rosuvastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol biosynthesis.
CRESTOR is indicated:
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as an adjunct to diet to reduce elevated total-C, LDL-C, ApoB, nonHDL-C, and TG levels and to increase HDL-C in patients with primary hypercholesterolemia (heterozygous familial and nonfamilial) and mixed dyslipidemia (Fredrickson Type IIa and IIb);
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as an adjunct to diet for the treatment of patients with elevated serum TG levels (Fredrickson Type IV);
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to reduce LDL-C, total-C, and ApoB in patients with homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable.
According to NCEP-ATPIII guidelines, therapy with lipid-altering agents should be a component of multiple-risk-factor intervention in individuals at increased risk for coronary heart disease due to hypercholesterolemia. The two major modalities of LDL-lowering therapy are therapeutic lifestyle changes (TLC) and drug therapy. The TLC Diet stresses reductions in saturated fat and cholesterol intake.
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CRESTOR NEWS HIGHLIGHTS Media Articles Related to Crestor (Rosuvastatin)
Study Might Prompt Expanded Use Of Crestor, Increase U.S. Health Care Costs By $10B Annually, Analysis Finds
Source: Statins News From Medical News Today [2008.11.12]
Crestor Can Reduce Risk For Cardiovascular Events In Patients With High Levels Of Protein, Study Finds
Source: Cholesterol News From Medical News Today [2008.11.11]
Crestor FAQ: New Benefits for Statins
Source: MedicineNet Cholesterol Specialty [2008.11.11]
CRESTOR Demonstrates Dramatic CV Risk Reduction In A Large Statin Outcomes Study
Source: Cholesterol News From Medical News Today [2008.11.10]
Statins May Benefit People With Low Cholesterol
Source: Statins News From Medical News Today [2008.11.10]
Published Studies Related to Crestor (Rosuvastatin)
Statin therapy alters the relationship between apolipoprotein B and low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol targets in high-risk patients: the MERCURY II (Measuring Effective Reductions in Cholesterol Using Rosuvastatin) trial. [2008.08.19]
Hepatic nuclear factor 1alpha inhibitor ursodeoxycholic acid influences pharmacokinetics of the organic anion transporting polypeptide 1B1 substrate rosuvastatin and bilirubin. [2008.08]
Simvastatin and rosuvastatin mobilize Endothelial Progenitor Cells but do not prevent their acute decrease during systemic inflammation. [2008.04.21]
The effect of a combination antacid preparation containing aluminium hydroxide and magnesium hydroxide on rosuvastatin pharmacokinetics. [2008.04]
Indices of reverse cholesterol transport in subjects with metabolic syndrome after treatment with rosuvastatin. [2008.04]
Clinical Trials Related to Crestor (Rosuvastatin)
Compare the Safety & Efficacy of Rosuvastatin 40mg in Combination With Ezetimibe 10mg [Completed]
Assessment of Potential Interaction Between Ezetimibe and Rosuvastatin in Healthy Subjects With High Cholesterol (P03317)(COMPLETED) [Completed]
Polaris - Crestor 40 mg vs Atorvastatin 80 mg for 26 Weeks [Completed]
Prospective Evaluation of Proteinuria and Renal Function in Diabetic Patients With Progressive Renal Disease [Active, not recruiting]
Comparison of Rosuvastatin and Atorvastatin in Patients With Acute Coronary Syndrome [Completed]
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CRESTOR PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 5 ratings/reviews, Crestor has an overall score of 9.60. The effectiveness score is 9.60 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Crestor review by 47 year old male patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Highly Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | High Cholestrol |
| Dosage & duration: | | 1 pill per day taken daily for the period of 5 years |
| Other conditions: | | None |
| Other drugs taken: | | None | | |
Reported Results |
| Benefits: | | The treatment benefits were that my cholestrol levels went from 9 to the 4-5 level. This was demonstrated by regular blood test results. |
| Side effects: | | The only side effect occured in the first 3 months, where slight aching of the joints and muscles was experienced. This disappeared after 3 months. |
| Comments: | | A pill is taken every night before going to bed. |
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| | Crestor review by 45 year old male patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Considerably Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | Hypercholestremia |
| Dosage & duration: | | 20mg taken q.d. for the period of 3.5 years |
| Other conditions: | | pre-diabetes |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | During first 12 months... lowered total cholesterol by 100 points, LDL by 90 points, and triglycerides by 74.11 months after starting medication, angina brought me to the ER. Cardiac catheterization was done and 60% blockage found. 1 Year after that,more angina, another cath. and no change in blockage was found. |
| Side effects: | | I did not experience any side effects and still continue that way. During the first year, my doctor was running labs every 3 months and at no time were any abnormalities noticed. He continues to do labs at 6 month intervals now and as of last one(3 weeks ago), still no problems noticed. |
| Comments: | | Began dose at 20 mg/day and have remained at that dose for 3.5 years. During that first year I also made some nutritional modifications. I recognize now that it was a half-hearted effort, but the combination still provided very good results.As of today, my cholesterol numbers have gotten even better. total CHOL.=102 TRI=49 LDL=55 and HDL=37(started @38).I had lapband surgery 3 months ago and have made dramatic changes in nutrition in addition to the medication. |
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| | Crestor review by 46 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Highly Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | High cholesterol |
| Dosage & duration: | | 5 mg taken daily for the period of Still taking it |
| Other conditions: | | Famiy history of heart disease |
| Other drugs taken: | | None | | |
Reported Results |
| Benefits: | | My total cholesterol was lowered from 237 to 165 in 4 weeks. My HDL (good cholesterol) numbers were up and the LDLs (bad cholesterol) went down. My triglycerides were lowered as well. |
| Side effects: | | I have not experienced any side effects from this medication. |
| Comments: | | I had a heart scan after experiencing exercise-induced arrhythmia. One artery had 20-30% blockage, while the others were clear. Crestor and low dose aspirin were prescribed as an "aggressive form" of treatment. The cardiologist was very pleased with the results after only a month's trial. I would recommend Crestor to anyone contemplating statin treatment. |
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Page last updated: 2008-11-12
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