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Creon (Amylase / Lipase / Protease) - Drug Interactions, Contraindications, Overdosage, etc



No drug interactions have been identified. No formal interaction studies have been conducted.


There have been no reports of overdose in clinical trials or postmarketing surveillance with this formulation of CREON. Chronic high doses of pancreatic enzyme products have been associated with fibrosing colonopathy and colonic strictures. High doses of pancreatic enzyme products have been associated with hyperuricosuria and hyperuricemia, and should be used with caution in patients with a history of hyperuricemia, gout, or renal impairment. [see Dosage and Administration () and Warnings and Precautions ()] 2.2 5.1 [see Warnings and Precautions ()] 5.3




 Borowitz DS, Grand RJ, Durie PR, et al. Use of pancreatic enzyme supplements for patients with cystic fibrosis in the context of fibrosing colonopathy. 1995; 127: 681-684. 1 Journal of Pediatrics.

 Borowitz DS, Baker RD, Stallings V. Consensus report on nutrition for pediatric patients with cystic fibrosis. 2002 Sep; 35: 246-259. 2 Journal of Pediatric Gastroenterology Nutrition.

 Stallings VA, Stark LJ, Robinson KA, et al. Evidence-based practice recommendations for nutrition-related management of children and adults with cystic fibrosis and pancreatic insufficiency: results of a systematic review.. 2008; 108: 832-839. 3 Journal of the American Dietetic Association

 Dominguez-Munoz JE. Pancreatic enzyme therapy for pancreatic exocrine insufficiency. 2007; 9: 116-122. 4 Current Gastroenterology Reports.

 Smyth RL, Ashby D, O'Hea U, et al. Fibrosing colonopathy in cystic fibrosis: results of a case-control study. 1995; 346: 1247-1251. 5 Lancet.

 FitzSimmons SC, Burkhart GA, Borowitz DS, et al. High-dose pancreatic-enzyme supplements and fibrosing colonopathy in children with cystic fibrosis. 1997; 336: 1283-1289. 6 New England Journal of Medicine.

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