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Creon (Amylase / Lipase / Protease) - Indications and Dosage

 
 



INDICATIONS

CREON® 5 Capsules are indicated for patients with pancreatic exocrine insufficiency as is often associated with:

  • cystic fibrosis
  • chronic pancreatitis
  • post-pancreatectomy
  • post-gastrointestinal bypass surgery (e.g., Billroth II gastroenterostomy)
  • ductal obstruction from neoplasm (e.g.,of the pancreas or common bile duct)

DOSAGE AND ADMINISTRATION

Clinical experience should dictate initial starting dose. Doses should be taken during meals or snacks, not before or after. Do not take without food.

ADULTS AND CHILDREN OVER 6 YEARS OLD

Usual initial starting dosage is two to four CREON® 5 Capsules per meal or snack.

CHILDREN UNDER 6 YEARS OLD

The exact dosage of CREON® 5 Capsules should be selected based on clinical experience for this age group. Patients can be started on one to two capsules per meal or snack.

For cystic fibrosis patients, typical doses are 1,500-3,000 USP lipase units/kg/meal. Dosage should be adjusted according to the severity of the disease, control of steatorrhea and maintenance of good nutritional status. Doses in excess of 6,000 USP lipase units/kg/meal are not recommended.

Dose increases, if required, should occur with careful monitoring of body weight and stool fat content. When changing strengths of pancreatic enzyme products, care should be taken to maintain equivalent lipase units for each divided dosage.

It is important to ensure adequate hydration of patients at all times while taking pancreatic enzymes.

Where swallowing of capsules is difficult, the capsules may be carefully opened and the MINIMICROSPHERES® added to a small amount of soft food, with a pH less than 5.5. The soft food should be swallowed immediately without chewing and followed with a glass of water or juice to insure swallowing.

HOW SUPPLIED

CREON® 5 MINIMICROSPHERES® (Pancrelipase Delayed-release Capsules, USP) are available in a two-piece gelatin capsule (orange opaque top half, blue opaque bottom half) imprinted in white with "SOLVAY" and "1205". Each capsule contains tan-colored delayed-release MINIMICROSPHERES® of pancrelipase supplied in bottles of:

100...........................NDC 0032-1205-01

250...........................NDC 0032-1205-07

CREON® 5 Capsules must be stored at 25°C (77°F); excursions permitted to 15°-30°C (59°-86°F). [See USP Controlled Room Temperature.] PROTECT FROM MOISTURE. DO NOT REFRIGERATE. Dispense in tight, light-resistant containers. For human consumption only.

Manufactured By:

Solvay Pharmaceuticals GmbH,

Hannover, Germany

Marketed by:

Solvay

Pharmaceuticals, Inc.

Marietta, GA 30062

0814

4E Rev 6/98

©1998

Solvay Pharmaceuticals, Inc.

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