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Cosopt (Dorzolamide Hydrochloride / Timolol Maleate Ophthalmic) - Summary

 

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COSOPT SUMMARY

COSOPT (dorzolamide hydrochloride-timolol maleate ophthalmic solution) is the combination of a topical carbonic anhydrase inhibitor and a topical beta-adrenergic receptor blocking agent.

COSOPT is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers (failed to achieve target IOP determined after multiple measurements over time). The IOP-lowering of COSOPT b.i.d. was slightly less than that seen with the concomitant administration of 0.5% timolol b.i.d. and 2.0% dorzolamide t.i.d. (see CLINICAL PHARMACOLOGY, Clinical Studies).

COSOPT NEWS HIGHLIGHTS

Published Studies Related to Cosopt (Dorzolamide / Timolol Ophthalmic)

Dorzolamide/Timolol fixed combination versus latanoprost/timolol fixed combination in patients with primary open-angle glaucoma or ocular hypertension. [2008.02]

Comparison of the 24-hour intraocular pressure-lowering effects of latanoprost and dorzolamide/timolol fixed combination after 2 and 6 months of treatment. [2008.01]

Comparing the fixed combination brimonidine-timolol versus fixed combination dorzolamide-timolol in patients with elevated intraocular pressure. [2007.04]

A comparison of travoprost, latanoprost, and the fixed combination of dorzolamide and timolol in patients with pseudoexfoliation glaucoma. [2006.01]

A randomized trial assessing dorzolamide in patients with glaucoma who are younger than 6 years. [2005.09]

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Clinical Trials Related to Cosopt (Dorzolamide / Timolol Ophthalmic)

12-Month Stability of Diurnal IOP Control on Cosopt [Active, not recruiting]

Comparison of Efficacy of Two Groups of Glaucoma Drops (Xalatan vs.Cosopt) in Reducing Eye Pressure Following Laser (SLT)Treatment in the Management of Glaucoma. [Recruiting]

A Investigator Masked Parallel Comparison of Tolerability of Combigan and Cosopt [Recruiting]

Dry Eye Study With CosoptŪ Over 8 Weeks in Patients With Open-Angle Glaucoma or Ocular Hypertension [Active, not recruiting]

A 12week, Randomized, Evaluator-Masked, Parallel Group Comparing Evening Dosing Of Xalacom Vs Cosopt In Subj W/ Glaucoma [Completed]

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Page last updated: 2008-03-26

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