COSMEGEN SUMMARY
COSMEGEN ®
FOR INJECTION
(DACTINOMYCIN FOR INJECTION)
(Actinomycin D)
Dactinomycin is one of the actinomycins, a group of antibiotics produced by various species of
Streptomyces.
Dactinomycin is the principal component of the mixture of actinomycins produced by
Streptomyces parvullus.
Unlike other species of
Streptomyces,
this organism yields an essentially pure substance that contains only traces of similar compounds differing in the amino acid content of the peptide side chains.
COSMEGEN, as part of a combination chemotherapy and/or multi-modality treatment regimen, is indicated for the treatment of Wilms' tumor, childhood rhabdomyosarcoma, Ewing's sarcoma and metastatic, nonseminomatous testicular cancer.
COSMEGEN is indicated as a single agent, or as part of a combination chemotherapy regimen, for the treatment of gestational trophoblastic neoplasia.
COSMEGEN, as a component of regional perfusion, is indicated for the palliative and/or adjunctive treatment of locally recurrent or locoregional solid malignancies.
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