CORTIFOAM SUMMARY
CORTIFOAM®
(HYDROCORTISONE ACETATE RECTAL AEROSOL)
10% RECTAL FOAM
Cortifoam® (hydrocortisone acetate rectal aerosol) 10% Rectal Foam contains hydrocortisone acetate 10% in a base containing propylene glycol, emulsifying wax, polyoxyethylene-10-stearyl ether, cetyl alcohol, methylparaben, propylparaben, trolamine, purified water and inert propellants: isobutane and propane. Each application delivers approximately 900 mg of foam containing 80 mg of hydrocortisone (90 mg of hydrocortisone acetate).
Cortifoam® is indicated as adjunctive therapy in the topical treatment of ulcerative proctitis of the distal portion of the rectum in patients who cannot retain hydrocortisone or other corticosteroid enemas.
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NEWS HIGHLIGHTS
Published Studies Related to Cortifoam (Hydrocortisone Rectal)
Antimicrobial activity of iodoquinol 1%-hydrocortisone acetate 2% gel against ciclopirox and clotrimazole. [2008.10]
Commercially available topical formulations consisting of iodoquinol 1%-hydrocortisone acetate 2%, ciclopirox 0.77%, and clotrimazole 1%-betamethasone dipropionate 0.5% were assessed for their antimicrobial activity against cultures of Micrococcus luteus, Propionibacterium acnes, methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Corynebacterium aquaticum, Trichophyton mentagrophytes, Malassezia furfur, Microsporum canis, Candida albicans, Trichophyton rubrum, or Epidermophyton floccosum...
Neuroendocrine disorders in adult rats treated prenatally with hydrocortisone acetate. [2008.09]
We investigated the effects of hydrocortisone acetate administered to pregnant rats over the last gestational week on some neuroendocrine characteristics in adult female and male offspring... It was concluded that exposure to prenatal glucocorticoid is able to alter development of the neuroendocrine systems related to reproduction and stress responses both in males and females and resulted in modification of its sex-dimorphic features in adult life.
[Comparative study of prednisolone versus hydrocortisone acetate for treatment of patients with the classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency] [2008.02]
Hydrocortisone acetate is usually employed in the treatment of classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. In Brazil, however, oral hydrocortisone acetate is only available from manipulation pharmacies... Oral prednisolone may be an option for patients with CAH due to 21-hydroxylase deficiency.
Control of transdermal permeation of hydrocortisone acetate from hydrophilic and lipophilic formulations. [2008]
The purpose of this research was the preparation of four formulations containing hydrocortisone acetate (HCA) for topical application, including two aqueous systems (hydrophilic microemulsion and aqueous gel) and two systems with dominant hydrophobicity (hydrophobic microemulsion and ointment)... Experimental results allow the conclusion that gel and ointment can be suitable when it is desirable to minimize absorption of topically applied HCA as to keep the drug restricted to the diseased area and prevent side effects of the systemic presence of HCA.
Topical treatment of acute otitis externa: clinical comparison of an antibiotics ointment alone or in combination with hydrocortisone acetate. [2007.09]
The study was designed to investigate the potential contribution of hydrocortisone acetate to the efficacy and safety of an antibiotics ointment in the treatment of acute otitis externa (AOE). In a double-blind study 151 patients with a unilateral acute bacterial otitis externa were randomized either to receive an ointment with polymyxin-B sulfate (7,500 I.E./g) + bacitracin (300 I.E./g) alone (AB) or the same antibiotic ointment with 10 mg hydrocortisone acetate/g ointment (AB + HC)...
Clinical Trials Related to Cortifoam (Hydrocortisone Rectal)
Adherence to Topical Hydrocortisone 17-Butyrate 0.1% (LocoidŽ) Using Different Vehicles in Adults With Atopic Dermatitis [Active, not recruiting]
The purpose of this research study is to better understand how the study drug Locoid works
when people use it to treat atopic dermatitis.
Cortisol Control of Human Inflammatory Responses to Endotoxin [Completed]
The purpose of the research is to study a common and dangerous medical condition called
'septic shock' that often occurs in critically ill patients. In order to learn about septic
shock in humans, we will administer a substance called 'endotoxin' to participants in this
study. Endotoxin causes a temporary period of inflammation in the human body, a brief
'virtual' infection. This is an established method for the investigation of inflammation
properties. We are interested in how the natural hormone, cortisol, can affect the human
response to endotoxin. We know that when cortisol is given at the same time as endotoxin it
can decrease the inflammation that occurs due to endotoxin. In this study we will test
whether or not cortisol, when given the day before the endotoxin, will work to change the
inflammation that occurs due to endotoxin. In order to test this, two-thirds of the study
participants will receive cortisol on the day before they receive the endotoxin and one-third
of the study participants will receive a placebo (no medication) before the endotoxin.
Efficacy Study of Low-Dose Hydrocortisone Treatment for Fibromyalgia [Completed]
This study is based on clinical findings that some patients with fibromyalgia have a tendency
towards lower levels of the stress hormone cortisol. The hypothesis to be tested in this
study is that the administration of a very low-dose of cortisol which has no side effects
corrects this deficiency and results in an improvement of symptoms
Correlation Salivary Cortisol and Free Serum Cortisol to Total Serum Cortisol in MICU Septic Shock [Recruiting]
The purpose of the study is:
- to correlate salivary cortisol to free serum cortisol (as salivary cortisol is
considered to be almost complete free cortisol) and,
- to correlate free serum cortisol to total serum cortisol levels
Both in patients with septic shock (severe sepsis requiring vasopressors).
We believe that:
- total serum cortisol does not correlate with free serum cortisol in patient with septic
shock and,
- that salivary cortisol correlates with free serum cortisol and can be used to determine
the level of free serum cortisol.
Ketoconazole, Hydrocortisone and Dutasteride in Asymptomatic Hormone Refractory Prostate Cancer [Active, not recruiting]
The combination of ketaconazole and hydrocortisone is commonly used for the treatment of
prostate cancer. The purpose of this study is to determine if the addition of a drug called
dutasteride to this approved combination will make the combination more effective in treating
prostate cancer.
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