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Corgard (Nadolol / Bendroflumethiazide) - Summary



Exacerbation of Ischemic Heart Disease Following Abrupt Withdrawal—Hypersensitivity to catecholamines has been observed in patients withdrawn from beta-blocker therapy; exacerbation of angina and, in some cases, myocardial infarction have occurred after abrupt discontinuation of such therapy. When discontinuing chronically administered nadolol, particularly in patients with ischemic heart disease, the dosage should be gradually reduced over a period of one to two weeks and the patient should be carefully monitored. If angina markedly worsens or acute coronary insufficiency develops, nadolol administration should be reinstituted promptly, at least temporarily, and other measures appropriate for the management of unstable angina should be taken. Patients should be warned against interruption or discontinuation of therapy without the physician's advice. Because coronary artery disease is common and may be unrecognized, it may be prudent not to discontinue nadolol therapy abruptly even in patients treated only for hypertension.



CORZIDE (Nadolol and Bendroflumethiazide Tablets) for oral administration combines two antihypertensive agents: CORGARD® (nadolol), a nonselective beta-adrenergic blocking agent, and NATURETIN® (bendroflumethiazide), a thiazide diuretic-antihypertensive. Formulations: 40 mg and 80 mg nadolol per tablet combined with 5 mg bendroflumethiazide.

CORZIDE (Nadolol and Bendroflumethiazide Tablets) is indicated in the management of hypertension.

This fixed combination drug is not indicated for initial therapy of hypertension. If the fixed combination represents the dose titrated to the individual patient's needs, it may be more convenient than the separate components.

See all Corgard indications & dosage >>


Published Studies Related to Corgard (Nadolol / Bendroflumethiazide)

Controlled trial of ligation plus nadolol versus nadolol alone for the prevention of first variceal bleeding. [2010.07]
CONCLUSION: The addition of ligation to nadolol may increase adverse events and did not enhance effectiveness in the prophylaxis of first variceal bleeding.

Nadolol plus isosorbide mononitrate alone or associated with band ligation in the prevention of recurrent bleeding: a multicentre randomised controlled trial. [2009.08]
CONCLUSIONS: Adding EBL to pharmacological treatment did not reduce recurrent bleeding, the need for rescue therapy, or mortality, and was associated with more adverse events. Furthermore, associating EBL to drug therapy did not reduce the high rebleeding risk of HVPG non-responders. ISRCTN26221020.

Clinical trial: a randomized controlled study on prevention of variceal rebleeding comparing nadolol + ligation vs. hepatic venous pressure gradient-guided pharmacological therapy. [2009.02.15]
BACKGROUND: Hepatic venous pressure gradient (HVPG) monitoring of therapy to prevent variceal rebleeding provides strong prognostic information. Treatment of nonresponders to beta-blockers +/- nitrates has not been clarified. AIM: To assess the value of HVPG-guided therapy using nadolol + prazosin in nonresponders to nadolol + isosorbide-5-mononitrate (ISMN) compared with a control group treated with nadolol + ligation... CONCLUSIONS: In patients treated to prevent variceal rebleeding, the association of nadolol and prazosin effectively rescued nonresponders to nadolol and ISMN, improving the haemodynamic response observed in controls receiving nadolol and endoscopic variceal ligation. Our results also suggest that ligation may rescue nonresponders.

Comparison of endoscopic variceal ligation and nadolol plus isosorbide-5-mononitrate in the prevention of first variceal bleeding in cirrhotic patients. [2006.10]
BACKGROUND: Both drug therapy and banding ligation are widely used in the prevention of first variceal bleeding. This study compared the efficacy and safety of band ligation vs. combination of beta-blocker and nitrate for the prevention of first bleeding in patients with cirrhosis and high-risk esophageal varices... CONCLUSION: Our preliminary results suggest that endoscopic variceal ligation is similar to the combination of nadolol plus ISMN with regard to effectiveness and safety in the prevention of first variceal bleeding in patients with cirrhosis.

Comparative study between nadolol and 5-isosorbide mononitrate vs. endoscopic band ligation plus sclerotherapy in the prevention of variceal rebleeding in cirrhotic patients: a randomized controlled trial. [2006.08.15]
BACKGROUND: After variceal bleeding, cirrhotic patients should receive secondary prophylaxis. AIM: To compare nadolol plus 5-isosorbide mononitrate (5-ISMN) with endoscopic band ligation. The end points were rebleeding, treatment failure and death... CONCLUSION: This trial suggests no superiority of endoscopic band ligation over nadolol plus 5-ISMN mononitrate for the prevention of rebleeding in cirrhotic patients.

more studies >>

Clinical Trials Related to Corgard (Nadolol / Bendroflumethiazide)

A Trial of Ligation Plus Nadolol Versus Nadolol Alone in the Prophylaxis of First Variceal Bleeding in Cirrhosis [Completed]
The value of banding ligation plus beta blocker in the prophylaxis of first episodes of variceal bleeding has not yet been evaluated. This study was conducted to compare the efficacy and safety of banding ligation plus nadolol versus nadolol in the prophylaxis of first bleeding in cirrhotic patients with high-risk esophageal varices.

Nadolol for Proliferating Infantile Hemangiomas [Completed]
The purpose of this study is to explore the efficacy and safety of Nadolol in hemangiomas of infancy. The secondary objective is to assess the feasibility of conducting a randomized controlled trial comparing nadolol with corticosteroids and propranolol.

Oral Nadolol for the Treatment of Adults With Mild Asthma [Completed]
The purpose of this study is to confirm previous observations in asthmatics that chronic nadolol treatment reduces asthmatic airway hyper-responsiveness.

Nadolol Versus Propranolol in Children With Infantile Hemangiomas [Not yet recruiting]
The purpose of this study is to assess the efficacy and safety of oral propranolol versus nadolol in patients with Infantile Hemangiomas (IH) in a randomized, controlled, double-blinded study.

Relative Bioavailability Study of Nadolol (1 x 80 mg) Tablets Under Fasting Conditions [Completed]

more trials >>

Reports of Suspected Corgard (Nadolol / Bendroflumethiazide) Side Effects

Muscle Spasms (7)Dyspnoea (7)Injection Site Haemorrhage (6)Rales (6)Dizziness (6)Abdominal Distension (6)Oedema (6)Thrombocytopenia (6)Haematoma (6)Breast Cancer (6)more >>


Based on a total of 2 ratings/reviews, Corgard has an overall score of 9. The effectiveness score is 10 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.

Corgard review by 51 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
Treatment Info
Condition / reason:   high blood pressure
Dosage & duration:   40 mg taken daily for the period of 25 years
Other conditions:   none
Other drugs taken:   none
Reported Results
Benefits:   Eliminated the irregular heart beat as well as the occasional heart racing in addition to controlling the blood pressure. Initially started taking while on birth control and having stress sytems of a racing heart beat.
Side effects:   Initially tired more than normal but tiredness subsided in a few days
Comments:   take daily in the morning


Corgard review by 50 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Moderate Side Effects
Treatment Info
Condition / reason:   Mytral Valve Prolapse
Dosage & duration:   20 mg daily taken 1 per day for the period of 20 years
Other conditions:   low blood pressure, skipped beats
Other drugs taken:   Quinadine Gluconate
Reported Results
Benefits:   The medication works very well in conjunction with the Quinadine Gluconate to help calm the extra heart beats. I started on the medication when I was 19 and am still on it today at age 50. I've tried other new drugs but always seem to come back to this tried and true one.
Side effects:   The only complaint I have is that Corgard tends to lower your blood sugar if you are prone to that anyway. If I increased my dosages to over 20mg daily, I would have many problems with low blood sugar, even to the point of passing out. I learned how to deal with it, but wish it was not a side effect.
Comments:   I was put on Corgard because of the Mytral Valve prolapse. I am very symptomatic. This greatly reduced the skipped beats. I take 1 tablet at night before going to bed.

See all Corgard reviews / ratings >>

Page last updated: 2010-10-05

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