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Coreg (Carvedilol) - Summary

 
 



COREG SUMMARY

Carvedilol is a nonselective β-adrenergic blocking agent with α1-blocking activity.

Heart Failure

COREG is indicated for the treatment of mild-to-severe chronic heart failure of ischemic or cardiomyopathic origin, usually in addition to diuretics, ACE inhibitors, and digitalis, to increase survival and, also, to reduce the risk of hospitalization [see Drug Interactions and Clinical Studies].

Left Ventricular Dysfunction Following Myocardial Infarction

COREG is indicated to reduce cardiovascular mortality in clinically stable patients who have survived the acute phase of a myocardial infarction and have a left ventricular ejection fraction of ≤40% (with or without symptomatic heart failure) [see Clinical Studies].

Hypertension

COREG is indicated for the management of essential hypertension [see Clinical Studies (14.3, 14.4)]. It can be used alone or in combination with other antihypertensive agents, especially thiazide-type diuretics [see Drug Interactions].


See all Coreg indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Coreg (Carvedilol)

Endothelial function is unaffected by changing between carvedilol and metoprolol in patients with heart failure-a randomized study. [2011.10.15]
ABSTRACT: BACKGROUND: Carvedilol has been shown to be superior to metoprolol tartrate to improve clinical outcomes in patients with heart failure (HF), yet the mechanisms responsible for these differences remain unclear. We examined if there were differences in endothelial function, insulin stimulated endothelial function, 24 hour ambulatory blood pressure and heart rate during treatment with carvedilol, metoprolol tartrate and metoprolol succinate in patients with HF... CONCLUSION: Endothelial function remained unchanged when switching the beta blocker treatment from carvedilol to either metoprolol tartrate or metoprolol succinate in this study, where blood pressure and heart rate also remained unchanged in patients with mild HF. TRIAL REGISTRATION: Current Controlled Trials NCT00497003.

Prevention of chemotherapy-induced left ventricular dysfunction with enalapril and carvedilol: rationale and design of the OVERCOME trial. [2011.08]
BACKGROUND: The current treatment of hematologic malignancies includes diverse potentially cardiotoxic chemotherapy agents, including high-dose myeloablative regimens used in autologous hematopoietic stem cell transplantation (HSCT). Many of these treatments could induce left ventricular dysfunction (LVD), and limit their efficacy. Angiotensin-converting enzime inhibitors and beta-blockers prevent LVD and prolong survival after infarction, and recent animal and pilot clinical studies suggest that they can prevent the development of chemotherapy-induced cardiac toxicity... CONCLUSIONS: The OVERCOME study will be the first clinical trial to test the preventive efficacy on LVD of combined treatment with enalapril and carvedilol administered to patients with hematologic malignancies submitted to current treatment with intensive chemotherapy. Copyright (c) 2011 Elsevier Inc. All rights reserved.

Comparison of antihypertensive efficacy of carvedilol and nebivolol in mild-to-moderate primary hypertension: a randomized trial. [2011.06]
OBJECTIVE: The aim of the present study is to compare the antihypertensive effects of carvedilol and nebivolol in mild-to-moderate hypertensive patients... CONCLUSION: Although both carvedilol and nebivolol effectively decreased blood pressure compared to placebo, they showed similar efficacy for lowering blood pressure.

Titration to target dose of bisoprolol vs. carvedilol in elderly patients with heart failure: the CIBIS-ELD trial. [2011.06]
CONCLUSION: Overall tolerability to target doses was comparable. The pattern of intolerance, however, was different: bradycardia occurred more often in the bisoprolol group, whereas pulmonary adverse events occurred more often in the carvedilol group. This study is registered with controlled-trials.com, number ISRCTN34827306.

Effects of Beta-Blockade on Exercise Performance at High Altitude: A Randomized, Placebo-Controlled Trial Comparing the Efficacy of Nebivolol versus Carvedilol in Healthy Subjects. [2011.03.11]
Aims: Exposure to high altitude (HA) hypoxia decreases exercise performance in healthy subjects. Although beta-blockers are known to affect exercise capacity in normoxia, no data are available comparing selective and nonselective beta-adrenergic blockade on exercise performance in healthy subjects acutely exposed to HA hypoxia...

more studies >>

Clinical Trials Related to Coreg (Carvedilol)

Efficacy and Safety of Carvedilol SR Versus Carvedilol IR in Patients With Essential Hypertension [Completed]

Pharmacological Interaction Between Carvedilol and Methylenedioxymethamphetamine (MDMA) [Completed]
The purpose of this study is to determinate the effect of a pre-treatment with carvedilol, a alpha- and beta-adrenergic receptor blocker, on the pharmacodynamics and pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy"). The investigators hypothesize that carvedilol will attenuate the cardiovascular and subjective response to MDMA.

Cytochrome P450 2D6 Genotype on the Clinical Effect of Carvedilol [Completed]

Carvedilol 25 mg Film-coated Tablets, Bioequivalence Study of Dr. Reddys Under Fed Conditions [Completed]

Carvedilol 25 mg Film-coated Tablets, Bioequivalence Study of Dr. Reddys Under Fasting Conditions [Completed]

more trials >>

Reports of Suspected Coreg (Carvedilol) Side Effects

Asthenia (26)Dizziness (25)Constipation (24)Dyspnoea (22)Fatigue (21)Nausea (19)Drug Hypersensitivity (16)Drug Ineffective (15)Blood Glucose Increased (15)Vomiting (15)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 3 ratings/reviews, Coreg has an overall score of 8.67. The effectiveness score is 9.33 and the side effect score is 8.67. The scores are on ten point scale: 10 - best, 1 - worst.
 

Coreg review by 67 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Cardiomyopathy
Dosage & duration:   25 mg taken 2 times day for the period of 10 years and counting
Other conditions:   High Blood Pressure
Other drugs taken:   Pravacol, Aspirin, Fish Oil, Zestril
  
Reported Results
Benefits:   Ejection Fraction increased from 27% to 55% over period of 8 years. No longer have chest pain, congestive heart failure, difficulty breathing, can do almost anything I want to.
Side effects:   There was at least a six months adjustment period as the medicine was slowly increased. I had to learn my limits in activities and stict to them. No medicine works wonders without FAITH.
Comments:   Began with 3.25 mg dosage taken 2 times a day for two weeks. Then doubled the mgs each two weeks thereafter until up to 25 mgs two times a day.

 

Coreg review by 49 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   HEART
Dosage & duration:   25MG taken tid for the period of 2 YEARS
Other conditions:   high blood pressure
Other drugs taken:   BP
  
Reported Results
Benefits:   HEART WORKS BETTER -NO PVCS- less shortness of breath able to do physical activities again
Side effects:   DRY SKIN wrinkles decreased appetite takes the body a long time to adapt to such a radical change to the heart and lungs
Comments:   took the pill and get checkups? congestive heart failure first confirmed by an echocardiogram wore a holter for 24 hours to detect pvc's

 

Coreg review by 49 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   HEART
Dosage & duration:   25MG taken tid for the period of 2 YEARS
Other conditions:   high blood pressure
Other drugs taken:   BP
  
Reported Results
Benefits:   HEART WORKS BETTER -NO PVCS- less shortness of breath able to do physical activities again
Side effects:   DRY SKIN wrinkles decreased appetite takes the body a long time to adapt to such a radical change to the heart and lungs
Comments:   took the pill and get checkups? congestive heart failure first confirmed by an echocardiogram wore a holter for 24 hours to detect pvc's

See all Coreg reviews / ratings >>

Page last updated: 2011-12-09

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