Coreg CR (Carvedilol Phosphate) - Description

DESCRIPTION

Carvedilol phosphate is a nonselective β-adrenergic blocking agent with α₁-blocking activity. It is 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol dihydrogen phosphate. It is a racemic mixture with the following structure:

Carvedilol phosphate is a white to almost-white solid with a molecular weight of 513.5 (406.5 carvedilol free base) and a molecular formula of C₂₄H₂₆N₂O₄•H₃PO₄•1/2 H₂0.

COREG CR is available for once-a-day administration as controlled-release oral capsules containing 10, 20, 40, and 80 mg carvedilol phosphate. COREG CR capsules are filled with carvedilol phosphate immediate-release microparticles in addition to carvedilol phosphate controlled-release microparticles that are drug-layered and then coated with a methacrylic acid copolymer. Inactive ingredients include crospovidone, hydrogenated castor oil, hydrogenated vegetable oil, magnesium stearate, methacrylic acid copolymer, microcrystalline cellulose, and povidone.