Comtan (Entacapone) - Summary

COMTAN SUMMARY

Comtan® (entacapone) is available as tablets containing 200-mg entacapone.

Comtan (entacapone) is indicated as an adjunct to levodopa/carbidopa to treat patients with idiopathic Parkinson's Disease who experience the signs and symptoms of end-of-dose "wearing-off" (see CLINICAL PHARMACOLOGY, Clinical Studies).

Comtan's effectiveness has not been systematically evaluated in patients with idiopathic Parkinson's Disease who do not experience end-of-dose "wearing-off".

COMTAN NEWS HIGHLIGHTS

Media Articles Related to Comtan (Entacapone)

Parkinson's Disease
Source: MedicineNet levodopa-carbidopa Specialty [2005.12.17]

Transdermal Rotigotine Patch Safe, Effective in Early Idiopathic Parkinson's Disease
Source: Medscape Pharmacotherapy Headlines [2004.06.17]

Using Plastic Coatings To Help Medical Implants Connect With Neurons
Source: Eye Health / Blindness News From Medical News Today [2008.08.22]

Scientists Replicate Diseases In The Lab With New Stem Cell Lines
Source: Muscular Dystrophy / ALS News From Medical News Today [2008.08.08]

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Published Studies Related to Comtan (Entacapone)

Entacapone prolongs the reduction of PLM by levodopa/carbidopa in restless legs syndrome. [2007.11]

Comparison of 200 mg retarded release levodopa/carbidopa - with 150 mg levodopa/carbidopa/entacapone application: pharmacokinetics and efficacy in patients with Parkinson's disease. [2007]

Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study. [2006.06.27]

Entacapone increases levodopa exposure and reduces plasma levodopa variability when used with Sinemet CR. [2005.05]

Efficacy of combining levodopa with entacapone on quality of life and activities of daily living in patients experiencing wearing-off type fluctuations. [2005.01]

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Clinical Trials Related to Comtan (Entacapone)

Bioequivalence Study of Carbidopa/Levodopa/Entacapone Combination vs. Carbidopa/Levodopa Combination Plus Entacapone in Healthy Volunteers [Completed]

Bioequivalence Study of Carbidopa/Levodopa/Entacapone Combination vs. Carbidopa/Levodopa Combination Plus Entacapone in Healthy Volunteers [Completed]

Bioequivalence Study of Carbidopa/Levodopa/Entacapone Combination vs. Carbidopa/Levodopa Combination Plus Entacapone in Healthy Volunteers [Completed]

Bioequivalence Study of Carbidopa/Levodopa/Entacapone Combination vs. Carbidopa/Levodopa Combination Plus Entacapone Under Fasting Conditions in Healthy Volunteers [Completed]

Carbidopa/Levodopa/Entacapone Versus Immediate Release (IR) Carbidopa/Levodopa on Non-Motor Symptoms in Patients With Idiopathic Parkinson's Disease [Recruiting]

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