COMPAZINE SUMMARY
COMPAZINE®
brand of
prochlorperazine
antiemetic• antipsychotic • tranquilizer
Compazine (prochlorperazine) is a phenothiazine derivative, present in Compazine tablets and Spansule sustained release capsules as the maleate. Its chemical name is 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-10 H -phenothiazine (Z)-2-butenedioate (1:2).
COMPAZINE (prochlorperazine) is indicated for the following:
For control of severe nausea and vomiting.
For the treatment of schizophrenia.
Compazine (prochlorperazine) is effective for the short-term treatment of generalized non-psychotic anxiety. However, Compazine is not the first drug to be used in therapy for most patients with non-psychotic anxiety, because certain risks associated with its use are not shared by common alternative treatments (e.g., benzodiazepines).
When used in the treatment of non-psychotic anxiety, Compazine should not be administered at doses of more than 20 mg per day or for longer than 12 weeks, because the use of Compazine at higher doses or for longer intervals may cause persistent tardive dyskinesia that may prove irreversible (see WARNINGS).
The effectiveness of Compazine as treatmentfor non-psychotic anxiety was established in 4-week clinical studies of outpatients with generalized anxiety disorder. This evidence does not predict that Compazine will be useful in patients with other non-psychotic conditions in which anxiety, or signs that mimic anxiety, are found (e.g., physical illness, organic mental conditions, agitated depression, character pathologies, etc.).
Compazine has not been shown effective in the management of behavioral complications in patients with mental retardation.
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