- NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk (See WARNINGS).
- Combunox™ is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS).
- NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events (See WARNINGS).
CombunoxTM (Oxycodone HCl and Ibuprofen) Tablets
Combunox is supplied in a fixed combination tablet form for oral administration and combines the opioid analgesic agent, oxycodone HCl, with the nonsteroidal anti-inflammatory (NSAID) agent, ibuprofen.
Combunox tablet is indicated for the short term (no more than 7 days) management of acute, moderate to severe pain.
Media Articles Related to Combunox (Oxycodone / Ibuprofen)
Ultrasound First, Not CT, for Women's Pelvic Pain
Source: Medscape Emergency Medicine Headlines [2015.04.22]
Research backs ultrasound for its lack of radiation, lower cost, and reliable results, but CT is often the go-to choice.
Medscape Medical News
Caterpillar fungus could hold the key to relieving the pain of osteoarthritis
Source: Arthritis / Rheumatology News From Medical News Today [2015.04.22]
A drug from a parasitic mushroom that lives on caterpillars could become an effective new painkiller for people with osteoarthritis within the next six years, according to UK researchers.
World-first MRI study shows babies experience pain 'like adults'
Source: MRI / PET / Ultrasound News From Medical News Today [2015.04.21]
Researchers have discovered that babies feel pain in much the same way as adults, leading to experts recommending a review of neonatal pain management practice.
'Tamper-Proof' Narcotic Painkiller May Be Curbing Abuse: Study
Source: MedicineNet Chronic Pain Specialty [2015.04.21]
Title: 'Tamper-Proof' Narcotic Painkiller May Be Curbing Abuse: Study
Category: Health News
Created: 4/20/2015 12:00:00 AM
Last Editorial Review: 4/21/2015 12:00:00 AM
Neuropathic Ocular Pain as a Feature of Dry Eye
Source: Medscape Ophthalmology Headlines [2015.04.20]
Gain a better understanding of neuropathic ocular pain associated with dry eye, and how these findings could have implications for the diagnosis and treatment of dry eye symptoms.
Published Studies Related to Combunox (Oxycodone / Ibuprofen)
Combination oxycodone 5 mg/ibuprofen 400 mg for the treatment of pain after abdominal or pelvic surgery in women: a randomized, double-blind, placebo- and active-controlled parallel-group study. [2005.01]
BACKGROUND: The sensation of pain arises from both central and peripheral sites, and inflammation may be one of its underlying causes. Combination therapy with analgesic agents having multimodal mechanisms of action and complementary pharmacokinetic properties enhances pain relief by addressing the different pathways of pain while limiting individual drug doses and, therefore, the potential for adverse effects caused by any single agent. Oxycodone and ibuprofen each have been used effectively as monotherapy and in other combinations for the treatment of acute pain; a fixed combination of these analgesics may improve pain relief in the setting of abdominal or pelvic surgery, where trauma and any resultant inflammation may be present at the same time. OBJECTIVE: This study evaluated and compared the analgesic efficacy and tolerability of a single-dose combination tablet containing oxycodone 5 mg/ibuprofen 400 mg with either agent alone and with placebo in women who had undergone abdominal or pelvic surgery... CONCLUSIONS: In this population of women who had undergone abdominal or pelvic surgery, the combination of oxycodone 5 mg/ibuprofen 400 mg was significantly more effective than either agent alone or placebo in the treatment of moderate to severe postoperative pain.
Enfuvirtide: a review of its use in the management of HIV infection. 
Enfuvirtide (Fuzeon), a fusion inhibitor, is indicated in combination with other antiretroviral agents in the treatment of HIV infection in treatment-experienced adults and children aged >6 years.The addition of subcutaneous enfuvirtide to an optimised antiretroviral background regimen improved the virological and immunological response in treatment-experienced HIV-infected patients in the two large, well designed TORO (T-20 vs Optimised Regimen Only) trials...
Page last updated: 2015-04-22