- NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk (See WARNINGS).
- Combunox™ is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS).
- NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events (See WARNINGS).
CombunoxTM (Oxycodone HCl and Ibuprofen) Tablets
Combunox is supplied in a fixed combination tablet form for oral administration and combines the opioid analgesic agent, oxycodone HCl, with the nonsteroidal anti-inflammatory (NSAID) agent, ibuprofen.
Combunox tablet is indicated for the short term (no more than 7 days) management of acute, moderate to severe pain.
Media Articles Related to Combunox (Oxycodone / Ibuprofen)
Sufentanil Hybrid Receives CHMP Nod for Post-Op Pain
Source: Medscape General Surgery Headlines [2015.07.24]
The new product, Zalviso, is similar to another sufentanil-containing anesthetic-analgesic that has been available in the Netherlands for decades.
Preventing knee pain in at-risk adults with diabetes
Source: Arthritis / Rheumatology News From Medical News Today [2015.07.24]
UD-led study assesses impact of intensive diet/exercise programKnee pain in older adults, often caused by osteoarthritis, usually means more visits to the doctor and also can be a harbinger of...
US South Asians more reluctant to seek medication for pain
Source: Pain / Anesthetics News From Medical News Today [2015.07.24]
Health care workers should be culturally aware when caring for patients and families from the South Asian regionWhen compared with other ethnicities, Asians are the most unsatisfied with the...
Inhaled Cannabis Promising for Painful Diabetic Neuropathy
Source: Medscape NeurologyHeadlines [2015.07.23]
A new study has shown that inhaled cannabis can blunt the pain of diabetic neuropathy without impairing cognitive function.
Medscape Medical News
Nondrug Tx Best for Fibromyalgia: The Pain Medicine News Report
Source: MedPage Today Neurology [2015.07.22]
(MedPage Today) -- Also, new evidence supports medical marijuana use for chronic pain.
Published Studies Related to Combunox (Oxycodone / Ibuprofen)
Combination oxycodone 5 mg/ibuprofen 400 mg for the treatment of pain after abdominal or pelvic surgery in women: a randomized, double-blind, placebo- and active-controlled parallel-group study. [2005.01]
BACKGROUND: The sensation of pain arises from both central and peripheral sites, and inflammation may be one of its underlying causes. Combination therapy with analgesic agents having multimodal mechanisms of action and complementary pharmacokinetic properties enhances pain relief by addressing the different pathways of pain while limiting individual drug doses and, therefore, the potential for adverse effects caused by any single agent. Oxycodone and ibuprofen each have been used effectively as monotherapy and in other combinations for the treatment of acute pain; a fixed combination of these analgesics may improve pain relief in the setting of abdominal or pelvic surgery, where trauma and any resultant inflammation may be present at the same time. OBJECTIVE: This study evaluated and compared the analgesic efficacy and tolerability of a single-dose combination tablet containing oxycodone 5 mg/ibuprofen 400 mg with either agent alone and with placebo in women who had undergone abdominal or pelvic surgery... CONCLUSIONS: In this population of women who had undergone abdominal or pelvic surgery, the combination of oxycodone 5 mg/ibuprofen 400 mg was significantly more effective than either agent alone or placebo in the treatment of moderate to severe postoperative pain.
Enfuvirtide: a review of its use in the management of HIV infection. 
Enfuvirtide (Fuzeon), a fusion inhibitor, is indicated in combination with other antiretroviral agents in the treatment of HIV infection in treatment-experienced adults and children aged >6 years.The addition of subcutaneous enfuvirtide to an optimised antiretroviral background regimen improved the virological and immunological response in treatment-experienced HIV-infected patients in the two large, well designed TORO (T-20 vs Optimised Regimen Only) trials...
Page last updated: 2015-07-24