Cardiovascular Risk
- NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk (See WARNINGS).
- Combunox™ is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS).
Gastrointestinal Risk
- NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events (See WARNINGS).
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COMBUNOX SUMMARY
CombunoxTM (Oxycodone HCl and Ibuprofen) Tablets
Combunox is supplied in a fixed combination tablet form for oral administration and combines the opioid analgesic agent, oxycodone HCl, with the nonsteroidal anti-inflammatory (NSAID) agent, ibuprofen.
Combunox tablet is indicated for the short term (no more than 7 days) management of acute, moderate to severe pain.
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COMBUNOX NEWS HIGHLIGHTS
Media Articles Related to Combunox (Oxycodone / Ibuprofen)
Nearly Half Of US Adults Will Develop Painful Knee Osteoarthritis By Age 85: Study
Source: Arthritis / Rheumatology News From Medical News Today [2008.09.03]
1,500 Professionals From The Biotechnology Sector Will Participate In Biospain 2008
Source: Conferences News From Medical News Today [2008.09.02]
Diamyd Medical: Diamyd Medical's NTDDS Technology Effective Against Diabetes Pain
Source: Diabetes News From Medical News Today [2008.09.02]
Nurses Accurately Assess Pain In Children, Research Shows
Source: Nursing / Midwifery News From Medical News Today [2008.08.30]
Burnt Kids' Pain Lessened By Distracting Device
Source: Dermatology News From Medical News Today [2008.08.29]
Published Studies Related to Combunox (Oxycodone / Ibuprofen)
Combination oxycodone 5 mg/ibuprofen 400 mg for the treatment of pain after abdominal or pelvic surgery in women: a randomized, double-blind, placebo- and active-controlled parallel-group study. [2005.01]
Enfuvirtide: a review of its use in the management of HIV infection. [2005]
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