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Combunox (Oxycodone Hydrochloride / Ibuprofen) - Summary

 
 



Cardiovascular Risk

  • NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk (See WARNINGS).
  • Combunox™ is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS).

Gastrointestinal Risk

  • NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events (See WARNINGS).
 

COMBUNOX SUMMARY

CombunoxTM (Oxycodone HCl and Ibuprofen) Tablets

Combunox is supplied in a fixed combination tablet form for oral administration and combines the opioid analgesic agent, oxycodone HCl, with the nonsteroidal anti-inflammatory (NSAID) agent, ibuprofen.

Combunox tablet is indicated for the short term (no more than 7 days) management of acute, moderate to severe pain.


See all Combunox indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Combunox (Oxycodone / Ibuprofen)

Medical News Today: Tailbone pain: Causes, diagnosis, and relief
Source: Featured Health News from Medical News Today [2017.06.24]
Pain in the coccyx, or tailbone, can appear for a number of reasons, including injury, childbirth, and degeneration. Learn more in this article.

Tailbone pain: Causes, diagnosis, and relief
Source: Body Aches News From Medical News Today [2017.06.24]
Pain in the coccyx, or tailbone, can appear for a number of reasons, including injury, childbirth, and degeneration. Learn more in this article.

One in 10 in Rheumatic Pain Switch Back From a Biosimilar
Source: Medscape Orthopaedics Headlines [2017.06.22]
As more and more patients with rheumatic disease switch from a biologic to a biosimilar, a new study assesses how many switch back to the originator.
Medscape Medical News

Depressed Back Pain Patients Often Get Opioids
Source: MedicineNet Depression Specialty [2017.06.22]
Title: Depressed Back Pain Patients Often Get Opioids
Category: Health News
Created: 6/21/2017 12:00:00 AM
Last Editorial Review: 6/22/2017 12:00:00 AM

SAMURAI: Lasmiditan Reduces Pain in Acute Migraine
Source: Medscape NeurologyHeadlines [2017.06.20]
Patients with acute migraine taking the novel 5HT-1F agonist lasmiditan were more likely to have freedom from pain 2 hours later than those taking placebo, results of a phase 3 trial show.
Medscape Medical News

more news >>

Published Studies Related to Combunox (Oxycodone / Ibuprofen)

Combination oxycodone 5 mg/ibuprofen 400 mg for the treatment of pain after abdominal or pelvic surgery in women: a randomized, double-blind, placebo- and active-controlled parallel-group study. [2005.01]
BACKGROUND: The sensation of pain arises from both central and peripheral sites, and inflammation may be one of its underlying causes. Combination therapy with analgesic agents having multimodal mechanisms of action and complementary pharmacokinetic properties enhances pain relief by addressing the different pathways of pain while limiting individual drug doses and, therefore, the potential for adverse effects caused by any single agent. Oxycodone and ibuprofen each have been used effectively as monotherapy and in other combinations for the treatment of acute pain; a fixed combination of these analgesics may improve pain relief in the setting of abdominal or pelvic surgery, where trauma and any resultant inflammation may be present at the same time. OBJECTIVE: This study evaluated and compared the analgesic efficacy and tolerability of a single-dose combination tablet containing oxycodone 5 mg/ibuprofen 400 mg with either agent alone and with placebo in women who had undergone abdominal or pelvic surgery... CONCLUSIONS: In this population of women who had undergone abdominal or pelvic surgery, the combination of oxycodone 5 mg/ibuprofen 400 mg was significantly more effective than either agent alone or placebo in the treatment of moderate to severe postoperative pain.

Enfuvirtide: a review of its use in the management of HIV infection. [2005]
Enfuvirtide (Fuzeon), a fusion inhibitor, is indicated in combination with other antiretroviral agents in the treatment of HIV infection in treatment-experienced adults and children aged >6 years.The addition of subcutaneous enfuvirtide to an optimised antiretroviral background regimen improved the virological and immunological response in treatment-experienced HIV-infected patients in the two large, well designed TORO (T-20 vs Optimised Regimen Only) trials...

more studies >>


Page last updated: 2017-06-24

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