Combigan (Brimonidine Tartrate / Timolol Maleate Ophthalmic) - Indications and Dosage

Indications and Usage

COMBIGAN™ (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5% is an alpha adrenergic receptor agonist with a beta adrenergic receptor inhibitor indicated for the reduction of elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension who require adjunctive or replacement therapy due to inadequately controlled IOP; the IOP-lowering of COMBIGAN™ dosed twice a day was slightly less than that seen with the concomitant administration of 0.5% timolol maleate ophthalmic solution dosed twice a day and 0.2% brimonidine tartrate ophthalmic solution dosed three times per day.

Dosage and Administration

The recommended dose is one drop of COMBIGAN™ in the affected eye(s) twice daily approximately 12 hours apart. If more than one topical ophthalmic product is to be used, the different products should be instilled at least 5 minutes apart.

Dosage Forms and Strengths

Solution containing 2 mg/mL brimonidine tartrate and 5 mg/mL timolol (6.8 mg/mL timolol maleate).

How Supplied/Storage and Handling

COMBIGAN™ is supplied sterile, in white opaque plastic LDPE bottles and tips, with blue high impact polystyrene (HIPS) caps as follows:

5 mL in 10 mL bottle           NDC 0023-9211-05

10 mL in 10 mL bottle         NDC 0023-9211-10

Storage: Store between 15° to 25°C (59° to 77°F). Protect from light.