Published Studies Related to Colyte (Polyethylene Glycol 3350)
A randomised, double-blind study of polyethylene glycol 4000 and lactulose in the
treatment of constipation in children. 
treatment of chronic constipation in young children... CONCLUSIONS: PEG 4000 has superior efficacy to lactulose for the treatment of
Reduced cathartic bowel preparation for CT colonography: prospective comparison of 2-L polyethylene glycol and magnesium citrate. [2011.10]
PURPOSE: To prospectively compare adequacy of colonic cleansing, adequacy of solid stool and fluid tagging, and patient acceptance by using reduced-volume, 2-L polyethylene glycol (PEG) versus magnesium citrate bowel preparations for CT colonography... CONCLUSION: Reduced-volume PEG and magnesium citrate bowel preparations demonstrated adequate cleansing effectiveness for CT colonography, with better tagging and shorter interpretation time observed in the PEG group. Adequate polyp detection was maintained but requires further validation because of the small number of clinically important polyps. (c) RSNA, 2011.
Effect of bowel preparation with polyethylene glycol on quality of capsule endoscopy. [2011.06]
BACKGROUND AND AIMS: Capsule endoscopy (CE) has the problem that lumen visualization is impaired by bubbles, bile, and debris. The benefits of bowel preparation are still controversial and the best method remains to be determined. The objective of this study was to evaluate the effect of the method of bowel preparation on the quality of visualization and on transit time... CONCLUSIONS: Bowel preparation with PEG resulted in better image quality than fasting alone. No significant difference was observed between 2 and 4 l. PEG 2 l rather than 4 l may be a useful method of preparation for CE.
Low-volume bowel preparation is inferior to standard 4 1 polyethylene glycol. [2011.03]
BACKGROUND: Four liters or more of orally taken polyethylene glycol solution (PEG) has proved to be an effective large-bowel cleansing method prior to colonoscopy. The problem has been the large volume of fluid and its taste, which is unacceptable to some examinees. We aimed to investigate the effectiveness of 2 l PEG combined with senna compared with 4 l PEG for bowel preparation... CONCLUSIONS: 4 l PEG treatment is better than 36 mg senna and 2 l PEG as routine colonic cleansing before colonoscopy because of fewer failures.
Comparison of the effectiveness of polyethylene glycol 4000 without electrolytes and magnesium hydroxide in the treatment of chronic functional constipation in children. [2011.01]
OBJECTIVE: To compare the effectiveness of two drugs, polyethylene glycol 4000 without electrolytes and magnesium hydroxide, in the treatment of chronic functional constipation in children... CONCLUSION: The two laxatives showed no difference in effectiveness for the treatment of constipation. However, due to its better acceptance, because it is odorless and tasteless, polyethylene glycol proved to be a better option for treating chronic functional constipation.
Clinical Trials Related to Colyte (Polyethylene Glycol 3350)
Miralax (PEG 3350) vs. Golytely as Bowel Preparation for Screening Colonoscopy [Completed]
A major limitation to the widespread acceptance of colonoscopy as a procedure to screen for
colorectal cancer is the laxative preparation. Phosphate-based preps (e. g. Fleets
Phosphosoda) are now used on a limited basis because of their known association with renal
injury. Polyethylene glycol (PEG) mixed with a balanced electrolyte solution (e. g. Golytely)
has been used for over two decades for colon cleansing. The mixture is not very palatable
due to the electrolyte additives which include sodium sulfate.
To overcome the limitation of existing preps, gastroenterologists and colorectal surgeons
worldwide have been using PEG powder alone (same quantity as found in Golytely prep) not
mixed with electrolytes (Glycolax or Miralax) and dissolving this into 64 ounces of
Gatorade. Conservatively, we estimate that 25% of colonoscopies in the US are being done
with this prep. Anecdotally there have been reports (case series) that it is far more
palatable and the prep is equally efficacious. The active ingredient, PEG, is not changed
and therefore this is not surprising. The issue at present is that there has never been a
blinded study to confirm these claims.
This study will compare the efficacy of the two preps. There is no funding. The
investigators will charge insurance companies for the prep - this is our current practice.
The procedures will be done on healthy individuals referred for colon cancer screening and
the exam will be billed to their insurance. There will be no patient honorarium. The
investigators will check electrolytes to be sure patients do not develop hypokalemia with
the Gatorade prep.
Comparing 4L Golytely to 2L Golytely With 15mg Bisacodyl Regimens for Inpatient Colonic Preparation [Withdrawn]
The investigators wish to compare the efficacy and patient tolerability of a preparation
consisting of 2L Golytely (PEG + electrolytes) plus 15mg of bisacodyl vs the standard
preparation of 4L Golytely. The investigators hypothesize that 2L Golytely with 15mg
bisacodyl will show similar bowel cleansing efficacy while offering better tolerability.
A Trial Comparing Bowel Preparation and Patient Tolerability of Miralax Versus Golytely [Not yet recruiting]
Prior to colonoscopies, the colon is cleansed using a laxative. Golytely is approved by the
FDA for this purpose. Another laxative, called MiraLax, is approved by the FDA to relieve
constipation, but it is not approved specifically for preparation for a colonoscopy.
Nonetheless, it is commonly used in clinical practice for this purpose, just as is Golytely.
The purpose of this study is to compare Golytely and MiraLax in two ways: to see whether one
is better tolerated by patients than the other and to see whether one more effectively
cleanses the bowel than the other. The investigators' hypothesis is that these 2 bowel
preparation methods are equally effective in bowel cleansing, but that patients prefer
Miralax to Golytely.
Efficacy Study of Polyethylene Glycol 3350-electrolyte Solution (GoLYTELY«) Versus Lactulose in Patients With Hepatic Encephalopathy. [Completed]
This study is being done to find out if the laxative polyethylene glycol (also known as
GoLYTELY« or Miralax«) can treat your hepatic encephalopathy (confusion due to your liver
disease and/or cirrhosis) better and/or more safely than lactulose (another laxative). In
this study, the investigators will evaluate if polyethylene glycol (GoLYTELY«) is more
effective than lactulose on neurocognition (memory and thinking skills) and determine if it
decreases the hospital stay.
Amitiza« Plus GoLYTELY« Versus Placebo Plus GoLYTELY« for Outpatient Colonoscopy Preparation [Completed]
The primary objective is to compare the effectiveness and tolerance of Amitiza«
(lubiprostone) plus GoLYTELY« (polyethylene glycol-electrolyte solution) versus placebo and
GoLYTELY « (polyethylene glycol-electrolyte solution) as a bowel cleansing preparation for