NEWS HIGHLIGHTSMedia Articles Related to Collagenase Santyl (Collagenase)
BioSpecifics Technologies Corp. Announces Positive Top-Line Data From XIAFLEX® Phase IIa Study For Frozen Shoulder
Source: Rehabilitation / Physical Therapy News From Medical News Today [2013.03.28]
BioSpecifics Technologies Corp. (NASDAQ: BSTC), a biopharmaceutical company developing first in class collagenase-based products marketed as XIAFLEX® in the U.S., has announced positive, statistically significant top-line data from the Phase IIa study of XIAFLEX for the potential treatment of frozen shoulder (adhesive capsulitis)...
Space Heater Safety Tips Can Help Prevent Burns, Fires
Source: MedicineNet Burns Specialty [2013.03.11]
Title: Space Heater Safety Tips Can Help Prevent Burns, Fires
Category: Health News
Created: 3/8/2013 4:35:00 PM
Last Editorial Review: 3/11/2013 12:00:00 AM
Health Tip: Reduce Your Risk of Hot Water Burns
Source: MedicineNet Burns Specialty [2012.11.29]
Title: Health Tip: Reduce Your Risk of Hot Water Burns
Category: Health News
Created: 11/29/2012 8:35:00 AM
Last Editorial Review: 11/29/2012 12:00:00 AM
Topical Products for Muscle, Joint Pain May Cause Burns: FDA
Source: MedicineNet Muscle Cramps Specialty [2012.09.14]
Title: Topical Products for Muscle, Joint Pain May Cause Burns: FDA
Category: Health News
Created: 9/14/2012 10:05:00 AM
Last Editorial Review: 9/14/2012 12:00:00 AM
Burns (First Aid)
Source: MedicineNet Hyperkalemia Specialty [2008.10.28]
Title: Burns (First Aid)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 10/28/2008 12:00:00 AM
Published Studies Related to Collagenase Santyl (Collagenase)
Injectable collagenase Clostridium histolyticum: a new nonsurgical treatment for Dupuytren's disease. [2010.12]
PURPOSE: The Collagenase Option for the Reduction of Dupuytren's (CORD) II study investigated the efficacy and safety of injectable Xiaflex (collagenase clostridium histolyticum), in patients with Dupuytren's contracture... CONCLUSIONS: Collagenase clostridium histolyticum is the first Food and Drug Administration-approved, nonsurgical treatment option for adult Dupuytren's contracture patients with a palpable cord that is highly effective and well tolerated. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic I. Copyright (c) 2010. Published by Elsevier Inc.
Collagenase injection as nonsurgical treatment of Dupuytren's disease: 8-year follow-up. [2010.04]
PURPOSE: Collagenase has been investigated in phase II and phase III clinical trials for the treatment of Dupuytren's disease. The purpose of this study is to report 8-year follow-up results in a subset of patients who had collagenase injection for the treatment of Dupuytren's contracture... CONCLUSIONS: Enzymatic fasciotomy is safe and efficacious, with initial response to injection resulting in reduction of joint contracture to within 0 degrees -5 degrees of normal in 72 out of 80 patients. Initial evaluation of long-term recurrence rates suggests disease recurrence or progression in 4 out of 6 patients with MCP contractures and 2 patients with PIP contractures; however, recurrence was generally less severe than the initial contracture in the MCP group. In addition, patient satisfaction was high.
Percutaneous treatment of non-contained lumbar disc herniation by injection of oxygen-ozone combined with collagenase. [2009.12]
PURPOSE: To evaluate the therapeutic results of oxygen-ozone combined collagenase injection for the treatment of lumbar disc herniation compared to the surgery. And to explore the role of this minimally invasive treatment as an alternative to disc surgery... CONCLUSIONS: The combination of the oxygen-ozone with collagenase shows significant reductions in pain and improvements in function at 3 and 12 months, it can be considered as an option for the treatment of non-contained lumbar disc herniation instead of surgery.
Effect of collagenase and esterase on resin-dentin interface: a comparative study between a total-etch adhesive and a self-etch adhesive. [2009.10]
PURPOSE: To examine the effects of collagenase and esterase activity on the microtensile bond strength and nanoleakage at the resin-dentin interfaces of two adhesive systems: a total-etch adhesive (Single Bond 2: SB) and a self-etch adhesive (Clearfil SE Bond: SE)...
Injectable collagenase clostridium histolyticum for Dupuytren's contracture. [2009.09.03]
BACKGROUND: Dupuytren's disease limits hand function, diminishes the quality of life, and may ultimately disable the hand. Surgery followed by hand therapy is standard treatment, but it is associated with serious potential complications. Injection of collagenase clostridium histolyticum, an office-based, nonsurgical option, may reduce joint contractures caused by Dupuytren's disease... CONCLUSIONS: Collagenase clostridium histolyticum significantly reduced contractures and improved the range of motion in joints affected by advanced Dupuytren's disease. (ClinicalTrials.gov number, NCT00528606.) 2009 Massachusetts Medical Society
Clinical Trials Related to Collagenase Santyl (Collagenase)
Injectable Collagenase For Burns' Associated Contracture [Not yet recruiting]
A pilot experiment to test the efficiency of the enzyme Collagenase in treating contractures
which result's from burn's healing process.
So far, treatment of choice in patients with burn's created movement limiting contractures,
concentrated around supportive care. Patients were referred to surgical intervention only if
necessary. Treatment by injecting an external enzyme is avant-garde and hasn't been done
under such conditions.
This study might introduce a new kind of treatment, which can be done in ambulatory
environment .This type of treatment might significantly improve patients' function and
quality of life, with no need for a surgical intervention.
Collagenase and Needle Aponeurotomy: Single Modality Versus Combination Treatment for Dupuytren's Disease [Not yet recruiting]
Dupuytren's disease results in deformity of the hand and this can lead to trouble with daily
activities. Treatment traditionally involves cutting out diseased tissue, however this can
cause damage to important structures in the hand and results in large scars.
Needle aponeurotomy and collagenase injections are newer treatments that are thought to be
safer. These treatments allow quicker return to function. One drawback is that Dupuytren's
deformity may return more quickly than when all diseased tissue is surgically cut out.
This research study is designed to compare the effectiveness of needle aponeurotomy and
collagenase injection for Dupuytren's disease. This study will determine which procedure
gives the best results- either needle aponeurotomy, collagenase injection, or both
procedures in combination. Participants will be evaluated to see how they do in the long
term.
Collagenase in the Treatment of Cellulite [Not yet recruiting]
The purpose of this study is to determine if collagenase injection will reduce or eliminate
the appearance of cellulite of the thigh.
Wound Edge Changes Following Treatment With Santyl [Recruiting]
The goal of this study is to evaluate changes in the healing tissue of diabetic foot wounds
following 14 days of treatment with Santyl or its vehicle base.
Collagenase Total Occlusion-1 Trial [Recruiting]
A prospective, three-center, phase I safety and tolerability dose escalation study,
evaluating 28 subjects in 4 discrete dose cohorts of acute intracoronary injected
collagenase ranging from 300 - 1200 µg prior to routine standard-of-care percutaneous
revascularization procedures in subjects with chronic total coronary artery occlusions
(CTOs).
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