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Colistimethate (Colistimethate Sodium) - Summary

 
 



COLISTIMETHATE SUMMARY

Colistimethate for Injection, USP is a sterile parenteral antibiotic product which, when reconstituted (see Reconstitution ) is suitable for intramuscular or intravenous administration.   The color of the reconstituted solution is colorless to light yellow. Each vial contains colistimethate sodium or pentasodium colistinmethanesulfonate (150 mg colistin base activity) as a white to slightly yellow lyophilized cake.   The sodium content is approximately 0.07 mg (0.003 mEq) of sodium per milligram of Colistin.

Colistimethate for Injection, USP is indicated for the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli.  It is particularly indicated when the infection is caused by sensitive strains of Pseudomonas aeruginosa .  This antibiotic is not indicated for infections due to Proteus or Neisseria . Colistimethate for Injection, USP has proven clinically effective in treatment of infections due to the following gram-negative organisms: Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa .

Colistimethate for Injection, USP may be used to initiate therapy in serious infections that are suspected to be due to gram-negative organisms and in the treatment of infections due to susceptible gram-negative pathogenic bacilli. 

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Colistimethate for Injection, USP and other antibacterial drugs, Colistimethate for Injection, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.  When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy.  In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.


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NEWS HIGHLIGHTS

Media Articles Related to Colistimethate

Respiratory Infections: Pneumonia, Bronchitis, Flu, and More
Source: MedicineNet Chronic Cough Specialty [2016.06.23]
Title: Respiratory Infections: Pneumonia, Bronchitis, Flu, and More
Category: Slideshows
Created: 10/19/2015 12:00:00 AM
Last Editorial Review: 6/23/2016 12:00:00 AM

Pneumonia Treatment
Source: MedicineNet Pneumococcal Vaccination Specialty [2016.06.14]
Title: Pneumonia Treatment
Category: Doctor's & Expert's views on Symptoms
Created: 7/12/2013 12:00:00 AM
Last Editorial Review: 6/14/2016 12:00:00 AM

Patients with coeliac disease should receive pneumonia vaccine
Source: Respiratory / Asthma News From Medical News Today [2016.05.16]
Researchers have found that patients with coeliac disease are at high risk of acquiring pneumonia if they haven't received the pneumococcal vaccine.

Two-minute video boosts pneumonia vaccinations
Source: Respiratory / Asthma News From Medical News Today [2016.05.16]
Many older adults don't get pneumococcal vaccination. A simple two-minute video about pneumococcal vaccination sent to patients before a primary care visit tripled the likelihood they would get...

Pneumonia vs. Walking Pneumonia
Source: MedicineNet Pneumococcal Vaccination Specialty [2016.05.06]
Title: Pneumonia vs. Walking Pneumonia
Category: Doctor's & Expert's views on Symptoms
Created: 5/12/2011 12:00:00 AM
Last Editorial Review: 5/6/2016 12:00:00 AM

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Published Studies Related to Colistimethate

Randomized controlled trial of nebulized colistimethate sodium as adjunctive therapy of ventilator-associated pneumonia caused by Gram-negative bacteria. [2010.12]
BACKGROUND: Cases of ventilator-associated pneumonia (VAP) due to multidrug-resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa are common in hospitalized patients at Siriraj Hospital, Bangkok, Thailand. Parenteral colistimethate sodium (CMS) has been used for therapy of VAP caused by MDR A. baumannii and P. aeruginosa at Siriraj Hospital over the past few years, with modest favourable outcomes. Objectives To determine whether nebulized CMS as adjunctive therapy of Gram-negative VAP was safe and beneficial... CONCLUSIONS: Nebulized CMS as adjunctive therapy of Gram-negative VAP seems to be safe. However, a beneficial effect on clinical outcomes of adjunctive nebulized CMS for therapy of Gram-negative VAP was not ascertained.

Randomized controlled trial of nebulized colistimethate sodium as adjunctive therapy of ventilator-associated pneumonia caused by Gram-negative bacteria. [2010.09.28]
Background Cases of ventilator-associated pneumonia (VAP) due to multidrug-resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa are common in hospitalized patients at Siriraj Hospital, Bangkok, Thailand... However, a beneficial effect on clinical outcomes of adjunctive nebulized CMS for therapy of Gram-negative VAP was not ascertained.

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Page last updated: 2016-06-23

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