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Colcrys (Colchicine) - Summary

 
 



COLCRYS SUMMARY

Colchicine is an alkaloid chemically described as (S)N- (5,6,7,9-tetrahydro- 1,2,3, 10-tetramethoxy-9-oxobenzo [alpha] heptalen-7-yl) acetamide with a molecular formula of C22H25NO6 and a molecular weight of 399.

COLCRYS (colchicine, USP) tablets are an alkaloid indicated for:

  • Prophylaxis and Treatment of Gout Flares in adults (1.1).
  • Familial Mediterranean fever (FMF) in adults and children 4 years or older (1.2).

COLCRYS is not an analgesic medication and should not be used to treat pain from other causes.

 

COLCRYS® (colchicine, USP) tablets are indicated for prophylaxis and the treatment of acute gout flares.

 

Prophylaxis of Gout Flares:

COLCRYS is indicated for prophylaxis of gout flares. 

Treatment of Gout Flares:

COLCRYS tablets are indicated for treatment of acute gout flares when taken at the first sign of a flare.

 

COLCRYS® (colchicine, USP) tablets are indicated in adults and children 4 years or older for treatment of familial Mediterranean fever (FMF).

 


See all Colcrys indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Colcrys (Colchicine)

Gout Quiz: What is Gout? Is There a Gout Diet?
Source: MedicineNet Arthritis Specialty [2017.09.19]
Title: Gout Quiz: What is Gout? Is There a Gout Diet?
Category: MedicineNet Quiz
Created: 1/26/2011 12:00:00 AM
Last Editorial Review: 9/19/2017 5:20:52 PM

Gout (Gouty Arthritis)
Source: MedicineNet Bunions Specialty [2017.07.07]
Title: Gout (Gouty Arthritis)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 7/7/2017 12:00:00 AM

Gout
Source: MedicineNet allopurinol Specialty [2017.05.30]
Title: Gout
Category: Symptoms and Signs
Created: 6/13/2014 12:00:00 AM
Last Editorial Review: 5/30/2017 12:00:00 AM

Gout Attack Symptoms, Causes, Treatment, and Diet
Source: MedicineNet Hydroxyapatite Specialty [2016.07.15]
Title: Gout Attack Symptoms, Causes, Treatment, and Diet
Category: Slideshows
Created: 6/6/2008 12:00:00 AM
Last Editorial Review: 7/15/2016 12:00:00 AM

Pseudogout
Source: MedicineNet Hydroxyapatite Specialty [2015.11.18]
Title: Pseudogout
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 11/18/2015 12:00:00 AM

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Published Studies Related to Colcrys (Colchicine)

Usefulness of colchicine to reduce perioperative myocardial damage in patients who underwent on-pump coronary artery bypass grafting. [2015]
The objective of the present study was to test whether a perioperative course of colchicine, in patients who underwent standard coronary artery bypass grafting, would result in reduced postoperative increase of myocardial injury biomarker levels. Patients were prospectively randomized to colchicine or placebo starting 48 hours before scheduled coronary artery bypass grafting and for 8 days thereafter (0.5 mg twice daily)...

Chuanhu anti-gout mixture versus colchicine for acute gouty arthritis: a randomized, double-blind, double-dummy, non-inferiority trial. [2014]
serious side effects... CONCLUSIONS: The Chuanhu anti-gout mixture was non-inferior to colchicine for the

Colchicine treatment for the prevention of bare-metal stent restenosis in diabetic patients. [2013]
Pharmacological interventions to decrease ISR could be of clinical relevance... CONCLUSIONS: Colchicine is associated with less neointimal hyperplasia and a

Colchicine treatment for recurrent pericarditis (CORP): a randomized trial. [2011.10.04]
BACKGROUND: Recurrence is the most common complication of pericarditis,affecting 10% to 50% of patients. OBJECTIVE: To evaluate the efficacy and safety of colchicine for the secondary prevention of recurrent pericarditis... CONCLUSION: Colchicine is safe and effective for secondary prevention of recurrent pericarditis.

Effect of colchicine compared with placebo on high sensitivity C-reactive protein in patients with acute coronary syndrome or acute stroke: a pilot randomized controlled trial. [2011.09.15]
There is a need for more effective therapies to reduce morbidity and mortality from cardiovascular disease. Inflammation plays a central role in the pathogenesis of atherosclerosis but no randomized studies have evaluated anti-inflammatory therapy in patients with acute coronary or cerebrovascular disease...

more studies >>

Clinical Trials Related to Colcrys (Colchicine)

Drug-Drug Interaction Study Between Colchicine and Diltiazem ER [Completed]
Colchicine is a substrate for both cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp). Extended-release diltiazem (diltiazem ER) is a potent inhibitor of both CYP3A4 and P-gp. This study will evaluate the effect of multiple doses of diltiazem ER on the pharmacokinetic profile of a single 0. 6 mg dose of colchicine. A secondary objective is to evaluate the safety and tolerability of this regimen in healthy volunteers. All study subjects will be monitored for adverse events throughout the study period.

Drug-Drug Interaction Study of Colchicine and Azithromycin [Completed]
Azithromycin is a possible weak to moderate inhibitor of CYP3A4, one of the enzymes responsible for the metabolism of colchicine. This study will evaluate the effect of multiple doses of azithromycin on the pharmacokinetic profile of a single 0. 6 mg dose of colchicine. A secondary objective is to evaluate the safety and tolerability of this regimen in healthy volunteers. All study subjects will be monitored for adverse events throughout the study period.

Drug-Drug Interaction Study Between Colchicine and Cyclosporine [Completed]
Colchicine is a substrate for both cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp). Cyclosporine is a potent inhibitor of both CYP3A4 and P-gp. This study will evaluate the effect of single-dose cyclosporine on the pharmacokinetic profile of a single 0. 6 mg dose of colchicine. A secondary objective is to evaluate the safety and tolerability of this regimen in healthy volunteers. All study subjects will be monitored for adverse events throughout the study period

Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion [Recruiting]

Drug Interaction Between Colchicine and Calcineurin Inhibitors in Renal Graft Recipients [Completed]
Ciclosporin inhibits P-glycoprotein should increase colchicine bioavailability whereas tacrolimus should not influence colchicine disposition. This is a prospective, controlled, open labeled study performed in renal graft recipients comparing colchicine single dose (1mg) pharmacokinetics in 14 patients treated with tacrolimus and 14 patients treated with cyclosporin.

more trials >>

Reports of Suspected Colcrys (Colchicine) Side Effects

Diarrhoea (82)Drug Ineffective (62)Nausea (22)Hypoaesthesia (20)Dizziness (18)Paraesthesia (18)OFF Label USE (16)Abdominal Pain Upper (14)Rash (12)Insomnia (12)more >>


Page last updated: 2017-09-19

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