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Cogentin (Benztropine Mesylate) - Description and Clinical Pharmacology

 
 



COGENTIN®
(Benztropine Mesylate Injection)

DESCRIPTION

Benztropine mesylate is a synthetic compound containing structural features found in atropine and diphenhydramine.
    It is designated chemically as 8-azabicyclo[3.2.1] octane, 3-(diphenylmethoxy)-, endo, methanesulfonate. Its empirical formula is C21H25NO•CH4O3S, and its structural formula is:

Benztropine mesylate is a crystalline white powder, very soluble in water, and has a molecular weight of 403.54.

COGENTINRegistered trademark of Merck &Co., Inc., Whitehouse Station, NJ, U.S.A. (Benztropine Mesylate) is supplied as a sterile injection for intravenous and intramuscular use.

Each milliliter of the injection contains:
Benztropine mesylate. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. ..1 mg
Sodium chloride. .. .. .. .. .. .. .. ... .. .. .. .. .. .. .. .. .. .. .. .. .. .. .9 mg
Water for injection q.s.. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. 1 mL

ACTIONS

COGENTIN possesses both anticholinergic and antihistaminic effects, although only the former have been established as therapeutically significant in the management of parkinsonism.

In the isolated guinea pig ileum, the anticholinergic activity of this drug is about equal to that of atropine; however, when administered orally to unanesthetized cats, it is only about half as active as atropine.

In laboratory animals, its antihistaminic activity and duration of action approach those of pyrilamine maleate.

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