NEWS HIGHLIGHTS
Published Studies Related to Cogentin (Benztropine)
Assessment of reinforcing effects of benztropine analogs and their effects on cocaine self-administration in rats: comparisons with monoamine uptake inhibitors. [2009.05]
Benztropine (BZT) analogs inhibit dopamine uptake but are less effective than cocaine in producing behavioral effects predicting abuse liability. The present study compared reinforcing effects of intravenous BZT analogs with those of standard monoamine uptake inhibitors and the effects of their oral pretreatment on cocaine self-administration...
The novel N-substituted benztropine analog GA2-50 possesses pharmacokinetic and pharmacodynamic profiles favorable for a candidate substitute medication for cocaine abuse. [2008.12]
GA2-50 is a novel N-substituted benztropine analog with improved potency and selectivity for the dopamine transporter. The pharmacokinetic and pharmacodynamic properties of GA2-50 were characterized as a part of its preclinical evaluation as a substitute medication for cocaine abuse...
Formulation and biopharmaceutical evaluation of transdermal patch containing benztropine. [2008.06.05]
Benztropine (BZ) is a potent muscarinic receptor antagonist that has been used for the treatment of Parkinson disease. However, the oral administration of BZ is often limited because of its many dose-related side effects...
Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction. [2008.01.01]
The discovery and development of medications to treat addiction and notably, cocaine addiction, have been frustrated by both the complexity of the disorder and the lack of target validation in human subjects... Their unique pharmacological profiles have provided important insights into the reinforcing actions of cocaine and we propose that clinical investigation of novel dopamine uptake inhibitors will facilitate the discovery of cocaine-abuse medications.
Fatal exertional heat stroke in a patient receiving zuclopenthixol, quetiapine and benztropine. [2007.09]
OBJECTIVE: To report a case of fatal exertional heat stroke associated with the use of zuclopenthixol, quetiapine and benztropine. CASE SUMMARY: A 36-year-old male with a history of schizophrenia and bipolar disease was working as a roofer during the third day of a heat wave...
Clinical Trials Related to Cogentin (Benztropine)
Evaluation of Benztropine for Cocaine Craving - 2 [Completed]
The purpose of this study is to compare the efficacy of benztropine (or DA reuptake
inhibitor) with atropine and placebo in affecting stimulated craving to cocaine cues.
Anticholinergic Burden in Schizophrenia [Recruiting]
Anticholinergic antiparkinsonian agents often cause side-effects including cognitive
impairment, dry mouth, and constipation while they diminish antipsychotic-induced
parkinsonian symptoms. The introduction of second generation antipsychotics (SGA) brought
fewer neurological side effects. However, anticholinergic coprescription rates are still as
high as 12-65% in patients on SGA that are much higher than the incidence of EPS reported in
clinical trials (3-20%). This apparently discrepancy is likely explained, in part, by the
established tradition of routine use of this medications. Older patients are particularly
sensitive to anticholinergic side-effects due to age-related changes in pharmacokinetics and
pharmacodynamics. In this study, we will examine the safety and benefits of reducing the dose
of a frequently prescribed anticholinergics, benztropine, on cognitive function,
extrapyramidal symptoms, and psychotic symptoms in older subjects with a primary psychotic
disorder.
Efficacy of Antidepressants in Chronic Back Pain [Not yet recruiting]
This 12 week placebo controlled clinical trial tests the individual and combined effects of
an antidepressant medication and cognitive behavioral therapy for chronic back pain.
A Phase II/III Double-Blind Study of Amitriptyline and Mexiletine for Painful Neuropathy in HIV Infection [Completed]
To assess the efficacy, safety, and tolerability of amitriptyline hydrochloride versus
mexiletine hydrochloride in reducing pain intensity in patients with HIV-related painful
peripheral neuropathy.
No large-scale controlled clinical trials of symptomatic therapy for painful HIV-related
neuropathy have been attempted. Both amitriptyline and mexiletine have been useful in the
management of painful neuropathies; however, both are associated with certain toxicities. In
this comparative study of amitriptyline and mexiletine, benztropine mesylate also will be
included as an active placebo to mimic the side effects of the study drugs.
Effect of Antidepressants on Back Pain [Completed]
The purpose of this study is to determine whether different types of antidepressant medicines
relieve back pain that has lasted at least six months on a daily basis. Study participants
will be assigned to treatment with either a antidepressant acting on the serotonin system in
the brain (fluoxetine), one acting on the noradrenoline system (desipramine, or to a control
medication not expected to relieve pain (benztropine). Each participant will be seen at
least nine times during their 12 weeks on medication. This is a phase 2/3, outpatient
study.
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