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Codrix (Acetaminophen / Codeine Phosphate) - Summary

 
 



CODRIX SUMMARY

CODRIX™
(Acetaminophen
and Codeine Phosphate
Tablets, USP)

Acetaminophen and codeine is supplied in tablet form for oral administration.

Acetaminophen, 4'-hydroxyacetanalide, a slightly bitter, white, odorless, crystalline powder, is a non-opiate, non-salicylate analgesic and antipyretic.

Codeine phosphate, 7,8-didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol phosphate (1:1) (salt) hemihydrate, a white crystalline powder, is a narcotic analgesic and antitussive.

Each tablet contains:

Acetaminophen 500 mg

Codeine phosphate 15 mg

CODRIX™ is indicated for the relief of mild to moderately severe pain.


See all Codrix indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Codrix (Acetaminophen / Codeine)

The Effect of Pain Management Advice on Patient Satisfaction
Source: Medscape Anesthesiology Headlines [2016.07.22]
Does providing pain advice improve patient satisfaction?
Emergency Medicine Journal

Medical News Today: 8 Common Causes of Breast Pain
Source: Featured Health News from Medical News Today [2016.07.22]
Learn about some of the common causes of breast pain. These causes include skin changes, certain types of medication, and infections.

8 Common Causes of Breast Pain
Source: Breast Cancer News From Medical News Today [2016.07.22]
Learn about some of the common causes of breast pain. These causes include skin changes, certain types of medication, and infections.

Pain Raises Risk of Opioid Addiction
Source: MedicineNet Drug Abuse Specialty [2016.07.22]
Title: Pain Raises Risk of Opioid Addiction
Category: Health News
Created: 7/22/2016 12:00:00 AM
Last Editorial Review: 7/22/2016 12:00:00 AM

Biacuplasty vs Conventional Management for Lumbar Back Pain
Source: Medscape Anesthesiology Headlines [2016.07.21]
Is one of these treatment methods for lumbar discogenic pain more effective than the other?
Spine

more news >>

Published Studies Related to Codrix (Acetaminophen / Codeine)

Analgesic efficacy of rofecoxib compared with codeine/acetaminophen using a model of acute dental pain. [2005.10]
OBJECTIVE: To determine analgesic efficacy of a single oral dose of rofecoxib 50 mg compared with acetaminophen/codeine 600/60 mg, we conducted a double-blind, randomized, placebo- and active-comparator-controlled, parallel-group study... CONCLUSION: Rofecoxib provided superior analgesic efficacy compared with codeine/acetaminophen with fewer gastrointestinal and nervous system adverse events.

A randomized, double-blind, parallel-group study comparing the analgesic effect of etoricoxib to placebo, naproxen sodium, and acetaminophen with codeine using the dental impaction pain model. [2004.05]
OBJECTIVE: To compare the overall analgesic effect, including time to onset, peak and duration of effect for etoricoxib 120 mg, a new COX-2 selective inhibitor, in patients with acute pain to that of placebo. Naproxen sodium 550 mg and acetaminophen/codeine 600/60 mg were the active comparators.Etoricoxib was generally well tolerated.

Tramadol suppositories are less suitable for post-operative pain relief than rectal acetaminophen/codeine. [1999.07]
The suitability of tramadol suppositories for inclusion in our hospital formulary for the treatment of mild to moderate post-operative pain was evaluated. In an open randomized trial, rectal tramadol was compared with our standard treatment acetaminophen/codeine suppositories...

The analgesic efficacy of flurbiprofen compared to acetaminophen with codeine. [1991]
In a single-dose, parallel group, randomized block treatment allocation study, the relative analgesic efficacy of flurbiprofen, a nonsteroidal antiinflammatory drug, was compared to acetaminophen 650 mg with codeine 60 mg, zomepirac sodium 100 mg, and placebo... The results of this study support previous work on flurbiprofen.

Comparison of ibuprofen and acetaminophen with codeine following cosmetic facial surgery. [2009.10]
OBJECTIVES: To compare the efficacy and side effects of ibuprofen and acetaminophen with codeine when given postoperatively following cosmetic facial surgery and to assess whether bruising is worse or the incidence of hematoma is greater when ibuprofen is taken postoperatively. DESIGN: Prospective, double-blind, randomized trial. SETTING: Accredited outpatient surgery centre... CONCLUSIONS: Ibuprofen 400 mg is as effective as acetaminophen/codeine 600/60 mg for pain relief following cosmetic facial surgery. Ibuprofen is better tolerated, with fewer side effects, than acetaminophen with codeine. Ibuprofen given postoperatively does not result in increased bruising or increased incidence of hematoma.

more studies >>

Clinical Trials Related to Codrix (Acetaminophen / Codeine)

Comparison of Acetaminophen With Codeine and Ibuprofen for Children With Injuries [Completed]
We compared the pain relief of acetaminophen with codeine versus ibuprofen for children ages 5-18 years who came to the Pediatric Emergency Department with injuries to their arms or legs.

A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy [Completed]
Tonsillectomy is the most common pediatric surgical procedure performed in the US. The postoperative period can be particularly painful. Codeine (usually in mixed formulation with acetaminophen) is the most commonly prescribed opioid in the US. However, evolving data questions its ability to provide optimal pain relief, while avoiding side effects, especially in the postoperative setting. Tramadol may be a better option for children in the postoperative setting due to its well-documented analgesic properties, low potential for side effects, and excellent safety profile. Seventy-two children scheduled to undergo tonsillectomy (with or without adenoidectomy) at Children's will be invited to participate in a randomized, prospective, double-blinded study to evaluate the efficacy and side effects of codeine with acetaminophen versus tramadol. Using a 10-day take-home diary, caregivers will be asked to record daily information about their child's postoperative pain and other core outcomes and domains as recommended in the recent consensus statement put forth by the Pediatric Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) (McGrath et al., 2008). This study will offer new information regarding the efficacy and side effects associated with tramadol as compared with codeine/acetaminophen (the current practice standard) in a pediatric population. Hypotheses H1: Children who receive scheduled tramadol following tonsillectomy will report better pain control than children who receive scheduled codeine/acetaminophen. H2: Children who receive scheduled tramadol following tonsillectomy will report fewer side effects than children who receive scheduled codeine/acetaminophen.

Buprenorphine in the Treatment of Osteoarthritis (OA) in the Elderly [Completed]
The primary objective is to compare buprenorphine transdermal delivery system (BTDS) with standard- treatment in subjects with osteoarthritis (OA).

Acute Pediatric Fracture Analgesia Study [Completed]
A clinical trial comparing ibuprofen and acetaminophen with codeine for children after discharge from the emergency department. We hypothesize that Ibuprofen will provide 20% more effective analgesia compared to acetaminophen with codeine in children with uncomplicated forearm fractures.

Postoperative Analgesia in Laminectomy [Not yet recruiting]

more trials >>


Page last updated: 2016-07-22

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