and Codeine Phosphate
Acetaminophen and codeine is supplied in tablet form for oral administration.
Acetaminophen, 4'-hydroxyacetanalide, a slightly bitter, white, odorless, crystalline powder, is a non-opiate, non-salicylate analgesic and antipyretic.
Codeine phosphate, 7,8-didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol phosphate (1:1) (salt) hemihydrate, a white crystalline powder, is a narcotic analgesic and antitussive.
Each tablet contains:
Acetaminophen 500 mg
Codeine phosphate 15 mg
CODRIX™ is indicated for the relief of mild to moderately severe pain.
Media Articles Related to Codrix (Acetaminophen / Codeine)
Sufentanil Hybrid Receives CHMP Nod for Post-Op Pain
Source: Medscape General Surgery Headlines [2015.07.24]
The new product, Zalviso, is similar to another sufentanil-containing anesthetic-analgesic that has been available in the Netherlands for decades.
Preventing knee pain in at-risk adults with diabetes
Source: Arthritis / Rheumatology News From Medical News Today [2015.07.24]
UD-led study assesses impact of intensive diet/exercise programKnee pain in older adults, often caused by osteoarthritis, usually means more visits to the doctor and also can be a harbinger of...
US South Asians more reluctant to seek medication for pain
Source: Pain / Anesthetics News From Medical News Today [2015.07.24]
Health care workers should be culturally aware when caring for patients and families from the South Asian regionWhen compared with other ethnicities, Asians are the most unsatisfied with the...
Inhaled Cannabis Promising for Painful Diabetic Neuropathy
Source: Medscape NeurologyHeadlines [2015.07.23]
A new study has shown that inhaled cannabis can blunt the pain of diabetic neuropathy without impairing cognitive function.
Medscape Medical News
Nondrug Tx Best for Fibromyalgia: The Pain Medicine News Report
Source: MedPage Today Neurology [2015.07.22]
(MedPage Today) -- Also, new evidence supports medical marijuana use for chronic pain.
Published Studies Related to Codrix (Acetaminophen / Codeine)
Analgesic efficacy of rofecoxib compared with codeine/acetaminophen using a model of acute dental pain. [2005.10]
OBJECTIVE: To determine analgesic efficacy of a single oral dose of rofecoxib 50 mg compared with acetaminophen/codeine 600/60 mg, we conducted a double-blind, randomized, placebo- and active-comparator-controlled, parallel-group study... CONCLUSION: Rofecoxib provided superior analgesic efficacy compared with codeine/acetaminophen with fewer gastrointestinal and nervous system adverse events.
A randomized, double-blind, parallel-group study comparing the analgesic effect of etoricoxib to placebo, naproxen sodium, and acetaminophen with codeine using the dental impaction pain model. [2004.05]
OBJECTIVE: To compare the overall analgesic effect, including time to onset, peak and duration of effect for etoricoxib 120 mg, a new COX-2 selective inhibitor, in patients with acute pain to that of placebo. Naproxen sodium 550 mg and acetaminophen/codeine 600/60 mg were the active comparators.Etoricoxib was generally well tolerated.
Tramadol suppositories are less suitable for post-operative pain relief than rectal acetaminophen/codeine. [1999.07]
The suitability of tramadol suppositories for inclusion in our hospital formulary for the treatment of mild to moderate post-operative pain was evaluated. In an open randomized trial, rectal tramadol was compared with our standard treatment acetaminophen/codeine suppositories...
The analgesic efficacy of flurbiprofen compared to acetaminophen with codeine. 
In a single-dose, parallel group, randomized block treatment allocation study, the relative analgesic efficacy of flurbiprofen, a nonsteroidal antiinflammatory drug, was compared to acetaminophen 650 mg with codeine 60 mg, zomepirac sodium 100 mg, and placebo... The results of this study support previous work on flurbiprofen.
Comparison of ibuprofen and acetaminophen with codeine following cosmetic facial surgery. [2009.10]
OBJECTIVES: To compare the efficacy and side effects of ibuprofen and acetaminophen with codeine when given postoperatively following cosmetic facial surgery and to assess whether bruising is worse or the incidence of hematoma is greater when ibuprofen is taken postoperatively. DESIGN: Prospective, double-blind, randomized trial. SETTING: Accredited outpatient surgery centre... CONCLUSIONS: Ibuprofen 400 mg is as effective as acetaminophen/codeine 600/60 mg for pain relief following cosmetic facial surgery. Ibuprofen is better tolerated, with fewer side effects, than acetaminophen with codeine. Ibuprofen given postoperatively does not result in increased bruising or increased incidence of hematoma.
Clinical Trials Related to Codrix (Acetaminophen / Codeine)
Comparison of Acetaminophen With Codeine and Ibuprofen for Children With Injuries [Completed]
We compared the pain relief of acetaminophen with codeine versus ibuprofen for children ages
5-18 years who came to the Pediatric Emergency Department with injuries to their arms or
Acute Pediatric Fracture Analgesia Study [Completed]
A clinical trial comparing ibuprofen and acetaminophen with codeine for children after
discharge from the emergency department. We hypothesize that Ibuprofen will provide 20% more
effective analgesia compared to acetaminophen with codeine in children with uncomplicated
Postoperative Analgesia in Laminectomy [Not yet recruiting]
Chiropractic Care, Medication, and Self-Care for Neck Pain
This study will compare the effectiveness of chiropractic care, medications, and self-care on
neck pain, a very common condition. The broad, long-term objective of this study is to
identify effective therapies for neck pain sufferers and to increase understanding of neck
SB-705498 Dental Pain Study After Tooth Extraction
This clinical trial is a multi centre, randomised, single-blind, parallel group,
placebo-controlled, single oral dose study with a positive control arm. Patients previously
scheduled for 3rd molar tooth extraction, who are otherwise healthy, will be recruited. Upon
completion of surgery, e. g. prior to established pain, patients will be randomised to
treatment (SB-706598, placebo or co-codamol) and dosed with the study medication
Page last updated: 2015-07-24