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Codrix (Acetaminophen / Codeine Phosphate) - Summary

 
 



CODRIX SUMMARY

CODRIX™
(Acetaminophen
and Codeine Phosphate
Tablets, USP)

Acetaminophen and codeine is supplied in tablet form for oral administration.

Acetaminophen, 4'-hydroxyacetanalide, a slightly bitter, white, odorless, crystalline powder, is a non-opiate, non-salicylate analgesic and antipyretic.

Codeine phosphate, 7,8-didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol phosphate (1:1) (salt) hemihydrate, a white crystalline powder, is a narcotic analgesic and antitussive.

Each tablet contains:

Acetaminophen 500 mg

Codeine phosphate 15 mg

CODRIX™ is indicated for the relief of mild to moderately severe pain.


See all Codrix indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Codrix (Acetaminophen / Codeine)

Exercise Stimulates Pain Modulation in Fibromyalgia
Source: Medscape Medical News Headlines [2015.05.22]
Exercise activates areas of the brain associated with pain modulation, suggesting it could be an effective treatment for fibromyalgia.
Medscape Medical News

Subconscious learning shapes pain responses
Source: Pain / Anesthetics News From Medical News Today [2015.05.22]
In a new study led from Sweden's Karolinska Institutet, researchers report that people can be conditioned to associate images with particular pain responses - such as improved tolerance to pain ...

More Babies Born to Mothers Addicted to Pain Meds
Source: MedicineNet Pregnancy Drug Dangers Specialty [2015.05.22]
Title: More Babies Born to Mothers Addicted to Pain Meds
Category: Health News
Created: 5/22/2015 12:00:00 AM
Last Editorial Review: 5/22/2015 12:00:00 AM

By the Book: How to Roll Out a New Chest Pain Pathway
Source: MedPageToday.com - medical news plus CME for physicians [2015.05.21]
(MedPage Today) -- A new chest pain protocol?

Oral steroids for acute sciatica produce limited improvement in function and pain
Source: Pain / Anesthetics News From Medical News Today [2015.05.20]
Among patients with acute sciatica caused by a herniated lumbar disk (a condition also known as "acute radiculopathy"), a short course of oral steroids resulted in only modest improvement in...

more news >>

Published Studies Related to Codrix (Acetaminophen / Codeine)

Analgesic efficacy of rofecoxib compared with codeine/acetaminophen using a model of acute dental pain. [2005.10]
OBJECTIVE: To determine analgesic efficacy of a single oral dose of rofecoxib 50 mg compared with acetaminophen/codeine 600/60 mg, we conducted a double-blind, randomized, placebo- and active-comparator-controlled, parallel-group study... CONCLUSION: Rofecoxib provided superior analgesic efficacy compared with codeine/acetaminophen with fewer gastrointestinal and nervous system adverse events.

A randomized, double-blind, parallel-group study comparing the analgesic effect of etoricoxib to placebo, naproxen sodium, and acetaminophen with codeine using the dental impaction pain model. [2004.05]
OBJECTIVE: To compare the overall analgesic effect, including time to onset, peak and duration of effect for etoricoxib 120 mg, a new COX-2 selective inhibitor, in patients with acute pain to that of placebo. Naproxen sodium 550 mg and acetaminophen/codeine 600/60 mg were the active comparators.Etoricoxib was generally well tolerated.

Tramadol suppositories are less suitable for post-operative pain relief than rectal acetaminophen/codeine. [1999.07]
The suitability of tramadol suppositories for inclusion in our hospital formulary for the treatment of mild to moderate post-operative pain was evaluated. In an open randomized trial, rectal tramadol was compared with our standard treatment acetaminophen/codeine suppositories...

The analgesic efficacy of flurbiprofen compared to acetaminophen with codeine. [1991]
In a single-dose, parallel group, randomized block treatment allocation study, the relative analgesic efficacy of flurbiprofen, a nonsteroidal antiinflammatory drug, was compared to acetaminophen 650 mg with codeine 60 mg, zomepirac sodium 100 mg, and placebo... The results of this study support previous work on flurbiprofen.

Comparison of ibuprofen and acetaminophen with codeine following cosmetic facial surgery. [2009.10]
OBJECTIVES: To compare the efficacy and side effects of ibuprofen and acetaminophen with codeine when given postoperatively following cosmetic facial surgery and to assess whether bruising is worse or the incidence of hematoma is greater when ibuprofen is taken postoperatively. DESIGN: Prospective, double-blind, randomized trial. SETTING: Accredited outpatient surgery centre... CONCLUSIONS: Ibuprofen 400 mg is as effective as acetaminophen/codeine 600/60 mg for pain relief following cosmetic facial surgery. Ibuprofen is better tolerated, with fewer side effects, than acetaminophen with codeine. Ibuprofen given postoperatively does not result in increased bruising or increased incidence of hematoma.

more studies >>

Clinical Trials Related to Codrix (Acetaminophen / Codeine)

Comparison of Acetaminophen With Codeine and Ibuprofen for Children With Injuries [Completed]
We compared the pain relief of acetaminophen with codeine versus ibuprofen for children ages 5-18 years who came to the Pediatric Emergency Department with injuries to their arms or legs.

Acute Pediatric Fracture Analgesia Study [Completed]
A clinical trial comparing ibuprofen and acetaminophen with codeine for children after discharge from the emergency department. We hypothesize that Ibuprofen will provide 20% more effective analgesia compared to acetaminophen with codeine in children with uncomplicated forearm fractures.

Postoperative Analgesia in Laminectomy [Not yet recruiting]

Chiropractic Care, Medication, and Self-Care for Neck Pain
This study will compare the effectiveness of chiropractic care, medications, and self-care on neck pain, a very common condition. The broad, long-term objective of this study is to identify effective therapies for neck pain sufferers and to increase understanding of neck pain conditions.

SB-705498 Dental Pain Study After Tooth Extraction
This clinical trial is a multi centre, randomised, single-blind, parallel group, placebo-controlled, single oral dose study with a positive control arm. Patients previously scheduled for 3rd molar tooth extraction, who are otherwise healthy, will be recruited. Upon completion of surgery, e. g. prior to established pain, patients will be randomised to treatment (SB-706598, placebo or co-codamol) and dosed with the study medication

more trials >>


Page last updated: 2015-05-22

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