NEWS HIGHLIGHTSMedia Articles Related to Codeine
Codeine Risky for Kids After Certain Surgeries, FDA Says
Source: MedicineNet acetaminophen Specialty [2013.02.22]
Title: Codeine Risky for Kids After Certain Surgeries, FDA Says
Category: Health News
Created: 2/21/2013 2:36:00 PM
Last Editorial Review: 2/22/2013 12:00:00 AM
FDA: Codeine May Be Risky for Kids After Surgery
Source: MedicineNet codeine Specialty [2012.08.16]
Title: FDA: Codeine May Be Risky for Kids After Surgery
Category: Health News
Created: 8/16/2012 11:00:00 AM
Last Editorial Review: 8/16/2012 12:00:00 AM
Codeine After Surgery Could Endanger Certain Kids: Study
Source: MedicineNet codeine Specialty [2012.04.11]
Title: Codeine After Surgery Could Endanger Certain Kids: Study
Category: Health News
Created: 4/11/2012 10:05:00 AM
Last Editorial Review: 4/11/2012 12:00:00 AM
Question Mark Over Combination Pain Relief Products
Source: Body Aches News From Medical News Today [2010.08.02]
Codeine is a weak opioid used in many combination pain relief products, but its role in managing acute pain is questioned in this month's edition of Australian Prescriber. In the article Dr Bridin Murnion, from the Drug Health Service at Royal Prince Alfred Hospital Sydney, discusses the evidence around combinations of different painkillers in the same tablet (eg...
Erectile Dysfunction Tied To Long Term Painkiller Use
Source: Erectile Dysfunction / Premature Ejaculation News From Medical News Today [2013.05.16]
A new study suggests that long term use of opioid prescription painkillers for back pain is tied to a higher risk of erectile dysfunction (ED). The findings are published in the 15 May online issue of the journal Spine. Lead author Richard A...
Published Studies Related to Codeine
A randomized controlled trial comparing acetaminophen, acetaminophen and ibuprofen, and acetaminophen and codeine for postoperative pain relief after Mohs surgery and cutaneous reconstruction. [2011.07]
BACKGROUND: There are no population-based data comparing analgesics after Mohs micrographic surgery (MMS) and reconstruction. OBJECTIVE To compare the efficacy in pain management of three analgesic combinations... CONCLUSIONS: The combination of Ac+Ib is superior to Ac alone or Ac+Co in controlling postoperative pain after MMS and cutaneous reconstruction. (c) 2011 by the American Society for Dermatologic Surgery, Inc.
Analgesia with paracetamol/tramadol vs. paracetamol/codeine in one day-surgery: a randomized open study. [2011.02]
OBJECTIVES: The analgesic efficacy of two fixed combinations of tramadol/paracetamol (TP 37.5/325 mg) and codeine/paracetamol (CP 30/500 mg) was compared in 122 patients undergoing one-day surgical procedures (hallux valgus, haemorrhoidectomy, varicectomy and inguinal hernia repair), randomly treated with TP 37.5/325 mg or CP 30/500 mg one tablet after surgery ended, followed by one tablet four times daily for 48 hours... CONCLUSIONS: We conclude that a fixed association of tramadol/paracetamol is a valuable and safe tool for pain management in day hospital surgery, especially whenever any effort is done to reduce the time for hospitalization.
Influence of codeine on lobeline-induced respiratory reflexes and sensations and on ventilation with exercise in healthy subjects. [2011.01.31]
In 15 healthy subjects, the effect of 60 mg oral codeine and placebo was examined on intravenously injected lobeline-elicited respiratory reflexes and sensations. Its influence was also studied on ventilation and appearance of distressful respiratory sensations with modest but incremental exercise.It also suggests that codeine decreased these receptors' known contribution to respiratory augmentation and motor inhibition during exercise, which was seen as a delay in the onset of, and a decrease in the magnitude of respiratory discomfort during treadmill walking and an increase in the duration walked by more than half the subjects.
The effects of methylnaltrexone alone and in combination with acutely administered codeine on gastrointestinal and colonic transit in health. [2010.10]
BACKGROUND: The short-term effects of methylnaltrexone (MNTX), a peripherally acting mu-opioid receptor antagonist, on gastrointestinal and colonic transit remain unclear. AIM: To compare the effects of placebo, codeine, subcutaneous (s.c.) MNTX and codeine with s.c. MNTX on gastrointestinal and colonic transit of solids in healthy humans... CONCLUSION: Methylnaltrexone does not alter gastrointestinal or colonic transit and does not reverse acute codeine-associated delayed gut transit in health.
Differential effect of codeine on thermal nociceptive sensitivity in sleepy versus nonsleepy healthy subjects. [2010.06]
Basal sleepiness-alertness modulates drug effects...
Clinical Trials Related to Codeine
A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy [Recruiting]
Tonsillectomy is the most common pediatric surgical procedure performed in the US. The
postoperative period can be particularly painful. Codeine (usually in mixed formulation with
acetaminophen) is the most commonly prescribed opioid in the US. However, evolving data
questions its ability to provide optimal pain relief, while avoiding side effects,
especially in the postoperative setting. Tramadol may be a better option for children in the
postoperative setting due to its well-documented analgesic properties, low potential for
side effects, and excellent safety profile. Seventy-two children scheduled to undergo
tonsillectomy (with or without adenoidectomy) at Children's will be invited to participate
in a randomized, prospective, double-blinded study to evaluate the efficacy and side effects
of codeine with acetaminophen versus tramadol. Using a 10-day take-home diary, caregivers
will be asked to record daily information about their child's postoperative pain and other
core outcomes and domains as recommended in the recent consensus statement put forth by the
Pediatric Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials
(IMMPACT) (McGrath et al., 2008). This study will offer new information regarding the
efficacy and side effects associated with tramadol as compared with codeine/acetaminophen
(the current practice standard) in a pediatric population.
Hypotheses
H1: Children who receive scheduled tramadol following tonsillectomy will report better pain
control than children who receive scheduled codeine/acetaminophen.
H2: Children who receive scheduled tramadol following tonsillectomy will report fewer side
effects than children who receive scheduled codeine/acetaminophen.
Comparison of the Efficacy of Oral Oxycodone and Oral Codeine in the Treatment of Postcraniotomy Pain [Recruiting]
The efficacy of codeine is dependent on its demethylation to morphine. This extent of
demethylation has wide inter-individual variability, making codeine's efficacy as a
analgesic variable. Oxycodone is a semi-synthetic opioid and is a weak agonist on mu opioid
receptors.
Codeine has been the mainstay of analgesia for patients after craniotomy for many years.
Traditionally, craniotomies were not thought to be very painful procedures, hence the use of
codeine, a moderately potent opioid (when compared to morphine).
However, in recent years, it has been found that up to 70% of post-craniotomy patients have
moderate to severe pain and codeine did not provide adequate analgesic relief. Many studies
have compared codeine to other drugs such as PCA morphine, fentanyl and tramadol, and
patients on these stronger opioids generally had lower pain scores and better satisfaction.
No study has been conducted to determine the efficacy of analgesia of oral oxycodone to oral
codeine.
Hence, the hypothesis is that oxycodone is more effective than codeine in providing pain
relief in post-craniotomy patients.
Analgesic Effect of Paracetamol, Paracetamol + Codeine, Ibuprofen and Their Combination [Recruiting]
The purpose of this study is to determine whether the combination of paracetamol
(acetaminophen) and other NSAIDs with or without weak opioids can give synergistic analgesic
effect.
Codeine in Mechanically Ventilated Neonates [Recruiting]
The purpose of this study is to determine the absorption and bioavailability of codeine in
relation to postnatal (PNA) and postconceptional (PCA) age; determine the parent drug
(codeine), its active metabolites, their formation rates and their ratios in relation with
PCA and PNA; and identify relevant genetic polymorphisms of opioid metabolism in the study
population and their potential relationship to the biodisposition and pharmacodynamic
effects of codeine. The study population is intubated and mechanically ventilated infants
equal to or greater than 26 weeks gestational age at birth and less than 4 weeks postnatal
age.
Codeine in Sickle Cell Disease [Recruiting]
The objective of this study is to determine if a subject’s genetic make-up would affect the
treatment response to codeine in subjects with sickle cell disease.
Reports of Suspected Codeine Side Effects
Drug Hypersensitivity (71),
Vomiting (17),
Toxicity TO Various Agents (14),
Nausea (13),
Pain (11),
Abdominal Distension (11),
Drug Abuse (10),
Cardio-Respiratory Arrest (10),
Completed Suicide (9),
Dyspnoea (9), more >>
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