Media Articles Related to Codeine
Long-Term Pain Outcomes With DBS in Parkinson's
Source: Medscape NeurologyHeadlines [2015.04.10]
Overall, pain improved in patients with Parkinson's 8 years after having deep brain stimulation, but new pain, mostly musculoskeletal, developed.
Medscape Medical News
MOVANTIK (naloxegol) tablets for the treatment of opioid-induced constipation in adult patients with chronic non-cancer pain launched in the US
Source: GastroIntestinal / Gastroenterology News From Medical News Today [2015.04.10]
AstraZeneca has announced that MOVANTIK (naloxegol) has launched in the United States.
Combining morphine and nortriptyline relieves chronic neuropathic pain better than using either drug alone
Source: Neurology / Neuroscience News From Medical News Today [2015.04.10]
Combining nortriptyline and morphine provides better pain relief than using either drug alone, according to a new study led by Queen's researcher Ian GilronThe combination of two well-known drugs...
Enhancing mechanism of capsaicin-evoked pain sensation
Source: Pain / Anesthetics News From Medical News Today [2015.04.09]
Calcium influx through TRPV1 causes anoctamin 1 activationDrs. Takayama and Tominaga in National Institute for Physiological Sciences (NIPS) (Okazaki Institute for Integrative Bioscience)...
Shift From IV to Oral Sedation for Pain Procedures?
Source: Medscape Emergency Medicine Headlines [2015.04.08]
One pain center reports benefits from a policy shifting from intravenous sedation to oral anxiolysis, but some argue IV sedation is often important.
Medscape Medical News
Published Studies Related to Codeine
Randomized clinical trial of hydrocodone/acetaminophen versus
codeine/acetaminophen in the treatment of acute extremity pain after emergency
department discharge. 
(DEA) Schedule III narcotics... CONCLUSIONS: Both medications decreased NRS pain scores by approximately 50%.
A randomized controlled trial comparing acetaminophen, acetaminophen and ibuprofen, and acetaminophen and codeine for postoperative pain relief after Mohs surgery and cutaneous reconstruction. [2011.07]
BACKGROUND: There are no population-based data comparing analgesics after Mohs micrographic surgery (MMS) and reconstruction. OBJECTIVE To compare the efficacy in pain management of three analgesic combinations... CONCLUSIONS: The combination of Ac+Ib is superior to Ac alone or Ac+Co in controlling postoperative pain after MMS and cutaneous reconstruction. (c) 2011 by the American Society for Dermatologic Surgery, Inc.
Analgesia with paracetamol/tramadol vs. paracetamol/codeine in one day-surgery: a randomized open study. [2011.02]
OBJECTIVES: The analgesic efficacy of two fixed combinations of tramadol/paracetamol (TP 37.5/325 mg) and codeine/paracetamol (CP 30/500 mg) was compared in 122 patients undergoing one-day surgical procedures (hallux valgus, haemorrhoidectomy, varicectomy and inguinal hernia repair), randomly treated with TP 37.5/325 mg or CP 30/500 mg one tablet after surgery ended, followed by one tablet four times daily for 48 hours... CONCLUSIONS: We conclude that a fixed association of tramadol/paracetamol is a valuable and safe tool for pain management in day hospital surgery, especially whenever any effort is done to reduce the time for hospitalization.
Influence of codeine on lobeline-induced respiratory reflexes and sensations and on ventilation with exercise in healthy subjects. [2011.01.31]
In 15 healthy subjects, the effect of 60 mg oral codeine and placebo was examined on intravenously injected lobeline-elicited respiratory reflexes and sensations. Its influence was also studied on ventilation and appearance of distressful respiratory sensations with modest but incremental exercise.It also suggests that codeine decreased these receptors' known contribution to respiratory augmentation and motor inhibition during exercise, which was seen as a delay in the onset of, and a decrease in the magnitude of respiratory discomfort during treadmill walking and an increase in the duration walked by more than half the subjects.
The effects of methylnaltrexone alone and in combination with acutely administered codeine on gastrointestinal and colonic transit in health. [2010.10]
BACKGROUND: The short-term effects of methylnaltrexone (MNTX), a peripherally acting mu-opioid receptor antagonist, on gastrointestinal and colonic transit remain unclear. AIM: To compare the effects of placebo, codeine, subcutaneous (s.c.) MNTX and codeine with s.c. MNTX on gastrointestinal and colonic transit of solids in healthy humans... CONCLUSION: Methylnaltrexone does not alter gastrointestinal or colonic transit and does not reverse acute codeine-associated delayed gut transit in health.
Clinical Trials Related to Codeine
A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy [Recruiting]
Tonsillectomy is the most common pediatric surgical procedure performed in the US. The
postoperative period can be particularly painful. Codeine (usually in mixed formulation with
acetaminophen) is the most commonly prescribed opioid in the US. However, evolving data
questions its ability to provide optimal pain relief, while avoiding side effects,
especially in the postoperative setting. Tramadol may be a better option for children in the
postoperative setting due to its well-documented analgesic properties, low potential for
side effects, and excellent safety profile. Seventy-two children scheduled to undergo
tonsillectomy (with or without adenoidectomy) at Children's will be invited to participate
in a randomized, prospective, double-blinded study to evaluate the efficacy and side effects
of codeine with acetaminophen versus tramadol. Using a 10-day take-home diary, caregivers
will be asked to record daily information about their child's postoperative pain and other
core outcomes and domains as recommended in the recent consensus statement put forth by the
Pediatric Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials
(IMMPACT) (McGrath et al., 2008). This study will offer new information regarding the
efficacy and side effects associated with tramadol as compared with codeine/acetaminophen
(the current practice standard) in a pediatric population.
H1: Children who receive scheduled tramadol following tonsillectomy will report better pain
control than children who receive scheduled codeine/acetaminophen.
H2: Children who receive scheduled tramadol following tonsillectomy will report fewer side
effects than children who receive scheduled codeine/acetaminophen.
Codeine in Sickle Cell Disease [Recruiting]
The objective of this study is to determine if a subject’s genetic make-up would affect the
treatment response to codeine in subjects with sickle cell disease.
A Study of Oral Codeine Sulfate in Pediatric Patients With Post-procedural Pain [Recruiting]
This is a multicenter, open-label study to evaluate the safety and PK of oral codeine
sulfate in pediatric subjects with mild to moderate post-procedural pain.
Assessment of Opioid Analgesia in Sickle Cell [Recruiting]
To develop and validate a non-invasive, in vivo, phenotyping method for CYP2D6 using the
non-injurious neuroselective electrical stimulation technique: pain perception
threshold/pain tolerance threshold (PPT/PTT) in children and adolescents with sickle cell
Comparison of the Efficacy of Oral Oxycodone and Oral Codeine in the Treatment of Postcraniotomy Pain [Recruiting]
The efficacy of codeine is dependent on its demethylation to morphine. This extent of
demethylation has wide inter-individual variability, making codeine's efficacy as a
analgesic variable. Oxycodone is a semi-synthetic opioid and is a weak agonist on mu opioid
Codeine has been the mainstay of analgesia for patients after craniotomy for many years.
Traditionally, craniotomies were not thought to be very painful procedures, hence the use of
codeine, a moderately potent opioid (when compared to morphine).
However, in recent years, it has been found that up to 70% of post-craniotomy patients have
moderate to severe pain and codeine did not provide adequate analgesic relief. Many studies
have compared codeine to other drugs such as PCA morphine, fentanyl and tramadol, and
patients on these stronger opioids generally had lower pain scores and better satisfaction.
No study has been conducted to determine the efficacy of analgesia of oral oxycodone to oral
Hence, the hypothesis is that oxycodone is more effective than codeine in providing pain
relief in post-craniotomy patients.
Reports of Suspected Codeine Side Effects
Drug Hypersensitivity (71),
Toxicity TO Various Agents (14),
Abdominal Distension (11),
Drug Abuse (10),
Cardio-Respiratory Arrest (10),
Completed Suicide (9),
Dyspnoea (9), more >>