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Clolar (Clofarabine) - Drug Interactions, Contraindications, Overdosage, etc

 
 



DRUG INTERACTIONS

No in-vivo drug interaction studies have been conducted [see Clinical Pharmacology ].

OVERDOSAGE

There were no known overdoses of Clolar. The highest daily dose administered to a human to date (on a mg/m2 basis) has been 70 mg/m2/day × 5 days (2 pediatric ALL patients). The toxicities included in these 2 patients included Grade 4 hyperbilirubinemia, Grade 2 and 3 vomiting, and Grade 3 maculopapular rash.

In a Phase 1 study of adults with refractory and/or relapsed hematologic malignancies, the recommended pediatric dose of 52 mg/m2/day was not tolerated.

CONTRAINDICATIONS

None

REFERENCES

  1. OSHA Hazardous Drugs. OSHA.
    http://www.osha.gov/SLTC/hazardousdrugs/index.html.

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