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Clobex (Clobetasol Propionate Topical) - Summary



CLOBEX (clobetasol propionate) Shampoo, 0.05%, contains clobetasol propionate, a synthetic fluorinated corticosteroid, for topical use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and antipruritic agents.
The chemical name of clobetasol propionate is 21-chloro-9-fluoro-11β, 17-dihydroxy-16β-methylpregna-1, 4-diene-3, 20-dione 17-propionate.


CLOBEX Shampoo, 0.05%, is a super-high potent topical corticosteroid formulation indicated for the treatment of moderate to severe forms of scalp psoriasis in subjects 18 years of age and older. Treatment should be limited to 4 consecutive weeks. The total dosage should not exceed 50 g (50 mL or 1.75 fl. oz.) per week.

Patients should be instructed to use CLOBEX Shampoo, 0.05%, for the minimum time period necessary to achieve the desired results [see Dosage and Administration].

Use in patients younger than 18 years of age is not recommended due to numerically high rates of hypothalamic-pituitary-adrenal (HPA) axis suppression [ see Warnings and Precautions and Use in Specific Populations (8.4) ].

Limitations of Use

CLOBEX Shampoo, 0.05%, should not be used on the face, groin or axillae. Avoid any contact of the drug product with the eyes and lips. In case of contact, rinse thoroughly with water all parts of the body that came in contact with the shampoo.

See all Clobex indications & dosage >>


Media Articles Related to Clobex (Clobetasol Topical)

Psoriasis Patients Face Increased Risk of Heart Attacks and Death
Source: Medscape Medical News Headlines [2017.09.29]
People with psoriasis, a chronic inflammatory disease, may be more likely than others to experience heart attacks and strokes at least in part because inflammation damages their vascular system, a recent study suggests.
Reuters Health Information

How Safe Are Various Systemic Therapies for Pediatric Psoriasis?
Source: Medscape Dermatology Headlines [2017.09.26]
Both methotrexate and TNF inhibitors appear to be safe for the majority of children, though cost is a big consideration.
Reuters Health Information

Psoriasis Quiz: Test Your Medical IQ
Source: MedicineNet Psoriasis Specialty [2017.09.19]
Title: Psoriasis Quiz: Test Your Medical IQ
Category: MedicineNet Quiz
Created: 4/21/2011 3:23:00 PM
Last Editorial Review: 9/19/2017 6:17:30 PM

Severe Psoriasis Linked to Higher Risk of Earlier Death
Source: MedicineNet Psoriasis Specialty [2017.09.06]
Title: Severe Psoriasis Linked to Higher Risk of Earlier Death
Category: Health News
Created: 9/5/2017 12:00:00 AM
Last Editorial Review: 9/6/2017 12:00:00 AM

Is Psoriasis Contagious?
Source: MedicineNet Psoriasis Specialty [2017.09.05]
Title: Is Psoriasis Contagious?
Category: Diseases and Conditions
Created: 6/22/2015 12:00:00 AM
Last Editorial Review: 9/5/2017 12:00:00 AM

more news >>

Published Studies Related to Clobex (Clobetasol Topical)

Clobetasol propionate, 0.05%, vs hydrocortisone, 1%, for alopecia areata in children: a randomized clinical trial. [2014]
IMPORTANCE: Alopecia areata is an idiopathic cause of hair loss with limited therapeutic repertoire. OBJECTIVE: To compare the efficacy and safety of a high- vs low-potency topical corticosteroid in pediatric patients...

A comparative study in efficacy and safety of 0.1% tacrolimus and 0.05% clobetasol propionate ointment in discoid lupus erythematosus by modified cutaneous lupus erythematosus disease area and severity index. [2012]
CONCLUSION: The present study proved the efficacy of twice-daily tacrolimus and

A double-blind, randomized, placebo-controlled trial of topical tacrolimus 0.1% vs. clobetasol propionate 0.05% in childhood vitiligo. [2011.09]
BACKGROUND: Both clobetasol propionate 0.05% (CP 0.05%) and tacrolimus 0.1% (T 0.1%) ointments have been shown to be efficacious and safe in treating vitiligo in the paediatric population. OBJECTIVES: To assess efficacy and safety of these two therapies compared with each other and with placebo... CONCLUSIONS: Both CP 0.05% and T 0.1% ointments offer similar benefit in paediatric vitiligo, both facial and nonfacial. The facial lesions responded faster than the nonfacial ones. (c) 2011 The Authors. BJD (c) 2011 British Association of Dermatologists.

Clobetasol propionate 0.05% spray for the management of moderate-to-severe plaque psoriasis of the scalp: results from a randomized controlled trial. [2011.08]
BACKGROUND: Clobetasol propionate 0.05% spray is available for treating moderate-to-severe plaque psoriasis; however, there is limited information with plaque psoriasis of the scalp. OBJECTIVE: Evaluate the efficacy, safety, and quality-of-life impact of clobetasol propionate 0.05% spray in patients with moderate to severe plaque psoriasis of the scalp... CONCLUSION: Treatment with clobetasol propionate 0.05% spray for up to four weeks is effective and well tolerated for moderate-to-severe plaque psoriasis of the scalp.

Comparison of clobetasol propionate cream plus coal tar vs. topical psoralen and solar ultraviolet A therapy in palmoplantar psoriasis. [2011.08]
AIM: Palmoplantar psoriasis (PPP) produces significant morbidity and requires prompt treatment. Topical agents form the mainstay of therapy. We compared the efficacy and side-effect profile of a steroid/coal-tar combination with topical psoralen and solar ultraviolet A (PUVAsol) in PPP... CONCLUSION: Both treatments had comparable efficacy. In both groups, patients experienced 'good improvement' after 16 weeks of therapy. (c) The Author(s). CED (c) 2011 British Association of Dermatologists.

more studies >>

Reports of Suspected Clobex (Clobetasol Topical) Side Effects

Blister (3)Pruritus (2)Scab (2)Skin Discolouration (2)Stevens-Johnson Syndrome (2)Drug Ineffective (1)Haemorrhage (1)Skin Exfoliation (1)Skin Burning Sensation (1)Erythema (1)more >>


Based on a total of 2 ratings/reviews, Clobex has an overall score of 9.50. The effectiveness score is 9 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.

Clobex review by 57 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
Treatment Info
Condition / reason:   hand dermatitis
Dosage & duration:   .05%, use very small amount (dosage frequency: morning and night during outbreaks) for the period of continuing for 3 years
Other conditions:   none
Other drugs taken:   none
Reported Results
Benefits:   This is the only treatment, besides cortizone shots, that had any effect. My outbreaks consisted of opened , cracked sores (up to 9 at a time)on my fingers that were extremely painful. With a shot of cortizone every couple of years, Clobex takes care of the rest. When I do not have an outbreak( and outbreaks are very mild if I treat them right away, I only use it a couple of times a week for prevention. I should mention that I need to be very careful and use gloves for many household cleaning tasks.
Side effects:   Nothing bad.
Comments:   Put a very small amount on my hands, smooth over all of my fingers. Use twice a day during an active outbreak. Use a couple of times a week thereafter, as prevention. I also use lots of moisturizer and wear gloves for cleaning tasks, etc.


Clobex review by 51 year old female patient

Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
Treatment Info
Condition / reason:   contact dermatitis
Dosage & duration:   .05% BID (dosage frequency: prn) for the period of 2 years as needed
Other conditions:   anxiety disorder
Other drugs taken:   klonopin
Reported Results
Benefits:   Clobex was effective in resolving minor contact dermatitis. It soothed the irritation and lessened the dermatitis rather quickly however, it was also used for what was thought as dermatitis around the mouth. Use continued for six months with no results. The rash was exacerbated by heat and a diagnosis of MRSA was made. The Clobex, due to steroids in the cream, did not clear the lesions but rather made them worse. Use was discontinued and Bactroban and Septra DS was highly effective at clearing the infection. Have since had no need for Clobex and have used alternate methods for any incidental dermatitis that may occur. For those who chose to traditional medications, I can recommend Clobex for mild to severe dermatitis. I was satisfied with the results, except for the misdiagnosis of Skin MRSA, yet glad to know from experience, the difference between these two rashes.
Side effects:   none
Comments:   Had developed contact dermatitis on my arm; cause unknown. dermatologist prescibed Clobex .05% BID until condition cleared. The solution went on easily, non-greasy and calmed any itching. No bandaging was needed. The dermatitis cleared quickly and no follow-up was necessary.

See all Clobex reviews / ratings >>

Page last updated: 2017-09-29

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