CLOBEX SUMMARY
CLOBEX™ (clobetasol propionate) Lotion, 0.05% contains clobetasol propionate, a synthetic fluorinated corticosteroid, for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and antipruritic agents.
CLOBEX™ (clobetasol propionate) Lotion, 0.05% is a super-high potent corticosteroid formulation indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses only in patients 18 years of age or older (see PRECAUTIONS). Treatment should be limited to 2 consecutive weeks. The total dosage should not exceed 50 g (50 mL or 1.75 fl.oz.) per week.
For the treatment of moderate to severe plaque psoriasis, localized lesions (less than 10% body surface area) that have not sufficiently improved after the initial 2-week treatment with CLOBEX™ (clobetasol propionate) Lotion, 0.05% may be treated for up to 2 additional weeks. Any additional benefits of extending treatment should be weighed against the risk of HPA axis suppression before prescribing for more than 2 weeks.
Patients should be instructed to use CLOBEX™ (clobe-tasol propionate) Lotion, 0.05% for the minimum amount of time necessary to achieve the desired results (see PRECAUTIONS).
Use in patients younger than 18 years of age is not recommended due to numerically high rates of HPA axis suppression (see PRECAUTIONS: Pediatric Use).
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NEWS HIGHLIGHTSMedia Articles Related to Clobex (Clobetasol Topical)
Men Suffer More Severe Psoriasis, Which Explains The Higher Costs Of Care For Men
Source: Health News from Medical News Today [2013.05.18]
Men often suffer from more severe cases of psoriasis than women, which may explain why the cost of care for men is higher. This is the conclusion of researchers at Sweden's Umea University in a new study. It is known that psoriasis affects about as many women as men. However, it has been shown, both in Sweden and internationally, that men receive more frequent and more expensive care for their disease, compared to women...
Psoriasis
Source: MedicineNet Actinic Keratosis Specialty [2013.05.16]
Title: Psoriasis
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 5/16/2013 12:00:00 AM
Scalp Psoriasis
Source: MedicineNet Hair Loss Specialty [2013.05.16]
Title: Scalp Psoriasis
Category: Diseases and Conditions
Created: 7/24/2012 3:21:00 PM
Last Editorial Review: 5/16/2013 12:00:00 AM
Psoriasis Increases Risk Of High Blood Pressure
Source: Hypertension News From Medical News Today [2013.04.11]
The World Health Organization recently began raising awareness for the risks that come with high blood pressure, and with this they recommended that healthcare professionals routinely scan for the health condition in people with psoriasis, an action praised by the International Federation of Psoriasis Associations (IFPA)...
Kids With Psoriasis More Likely to Be Overweight: Study
Source: MedicineNet Psoriasis Specialty [2012.11.20]
Title: Kids With Psoriasis More Likely to Be Overweight: Study
Category: Health News
Created: 11/19/2012 4:36:00 PM
Last Editorial Review: 11/20/2012 12:00:00 AM
Published Studies Related to Clobex (Clobetasol Topical)
A comparative study in efficacy and safety of 0.1% tacrolimus and 0.05%
clobetasol propionate ointment in discoid lupus erythematosus by modified
cutaneous lupus erythematosus disease area and severity index. [2012]
CONCLUSION: The present study proved the efficacy of twice-daily tacrolimus and
A double-blind, randomized, placebo-controlled trial of topical tacrolimus 0.1% vs. clobetasol propionate 0.05% in childhood vitiligo. [2011.09]
BACKGROUND: Both clobetasol propionate 0.05% (CP 0.05%) and tacrolimus 0.1% (T 0.1%) ointments have been shown to be efficacious and safe in treating vitiligo in the paediatric population. OBJECTIVES: To assess efficacy and safety of these two therapies compared with each other and with placebo... CONCLUSIONS: Both CP 0.05% and T 0.1% ointments offer similar benefit in paediatric vitiligo, both facial and nonfacial. The facial lesions responded faster than the nonfacial ones. (c) 2011 The Authors. BJD (c) 2011 British Association of Dermatologists.
Clobetasol propionate 0.05% spray for the management of moderate-to-severe plaque psoriasis of the scalp: results from a randomized controlled trial. [2011.08]
BACKGROUND: Clobetasol propionate 0.05% spray is available for treating moderate-to-severe plaque psoriasis; however, there is limited information with plaque psoriasis of the scalp. OBJECTIVE: Evaluate the efficacy, safety, and quality-of-life impact of clobetasol propionate 0.05% spray in patients with moderate to severe plaque psoriasis of the scalp... CONCLUSION: Treatment with clobetasol propionate 0.05% spray for up to four weeks is effective and well tolerated for moderate-to-severe plaque psoriasis of the scalp.
Comparison of clobetasol propionate cream plus coal tar vs. topical psoralen and solar ultraviolet A therapy in palmoplantar psoriasis. [2011.08]
AIM: Palmoplantar psoriasis (PPP) produces significant morbidity and requires prompt treatment. Topical agents form the mainstay of therapy. We compared the efficacy and side-effect profile of a steroid/coal-tar combination with topical psoralen and solar ultraviolet A (PUVAsol) in PPP... CONCLUSION: Both treatments had comparable efficacy. In both groups, patients experienced 'good improvement' after 16 weeks of therapy. (c) The Author(s). CED (c) 2011 British Association of Dermatologists.
Efficacious and safe management of moderate to severe scalp seborrhoeic dermatitis using clobetasol propionate shampoo 0.05% combined with ketoconazole shampoo 2%: a randomized, controlled study. [2011.07]
BACKGROUND: Topical antifungals and corticosteroids are the mainstay of treatment for seborrhoeic dermatitis. The short-contact clobetasol propionate 0.05% shampoo (CP) is an efficacious and safe once-daily treatment for scalp psoriasis. OBJECTIVES: To evaluate the efficacy and safety of CP alone and combined with ketoconazole shampoo 2% (KC) in the treatment of moderate to severe scalp seborrhoeic dermatitis... CONCLUSIONS: The combination therapy of twice-weekly CP alternating with twice-weekly KC provided significantly greater efficacy than KC alone and a sustained effect in the treatment of moderate to severe scalp seborrhoeic dermatitis. (c) 2011 The Authors. BJD (c) 2011 British Association of Dermatologists 2011.
Clinical Trials Related to Clobex (Clobetasol Topical)
A Comparison Between Clobetasol Propionate 0.05% (Clobex®) Spray and Clobetasol Propionate 0.05% (Olux®) Foam [Completed]
Efficacy, Tolerance and Satisfaction With CLOBEX® Spray When Used as Monotherapy or Add-on Therapy in Plaque Psoriasis [Completed]
Evaluation of the effectiveness of Clobex® Spray, 0. 05% when used as monotherapy or add-on
therapy to existing systemic or topical anti-psoriatic agents.
Maintenance Effect of Clobex Shampoo on Subjects With Moderate to Severe Scalp Psoriasis [Completed]
The objective of the study is to assess the maintenance effect on scalp psoriasis of Clobex®
Shampoo 0. 05% when used twice weekly.
Safety and Efficacy Study of Combination Treatment With Excimer Laser, Clobex Spray, and Vectical Ointment in the Treatment of Psoriasis [Recruiting]
This is a 12-week, open-label, pilot trial evaluating the efficacy and safety of the
combination of Clobex® spray with excimer laser therapy as the initial treatment of
generalized plaque psoriasis, followed by maintenance therapy with topical Vectical. The
study will be conducted in three distinct periods, namely Period A, Period B, and Period C,
each of 4 weeks duration. During Period A (weeks 1 through 4), patients will use Clobex®
spray twice daily along with excimer laser treatments twice weekly with the Photomedex
XTRAC® Velocity machine. The goal of Period A is to achieve PASI 75 in 100% of patients
within four weeks. During Period B (weeks 5 through 8), patients would be treated with
topical Vectical® twice daily. Thus, there is a steroid-free interval during which patients
will not be using Clobex® spray. The goal of Period B is to maintain the patient's response
using only non-steroid options. During Period C of the study, patients will use Clobex®
spray BID and Vectical® BID. Period C (weeks 9 through 12) will be a "booster" period in
which the goal is to see if 100% of patients can achieve PASI 90-100. Regarding excimer
laser therapy: all patients will be receiving excimer laser therapy twice weekly for the
first 6 weeks of the study (up to the halfway point) which is 12 excimer laser treatments.
At that point, only those patients achieving
Efficacy, Safety, Preference and Response Duration of Clobex® Spray and Taclonex® Ointment in Psoriasis [Completed]
Reports of Suspected Clobex (Clobetasol Topical) Side Effects
Blister (3),
Pruritus (2),
Scab (2),
Skin Discolouration (2),
Stevens-Johnson Syndrome (2),
Drug Ineffective (1),
Haemorrhage (1),
Skin Exfoliation (1),
Skin Burning Sensation (1),
Erythema (1), more >>
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 2 ratings/reviews, Clobex has an overall score of 9.50. The effectiveness score is 9 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.
| | Clobex review by 57 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | hand dermatitis |
| Dosage & duration: | | .05%, use very small amount (dosage frequency: morning and night during outbreaks) for the period of continuing for 3 years |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | This is the only treatment, besides cortizone shots, that had any effect. My outbreaks consisted of opened , cracked sores (up to 9 at a time)on my fingers that were extremely painful. With a shot of cortizone every couple of years, Clobex takes care of the rest. When I do not have an outbreak( and outbreaks are very mild if I treat them right away, I only use it a couple of times a week for prevention. I should mention that I need to be very careful and use gloves for many household cleaning tasks. |
| Side effects: | | Nothing bad. |
| Comments: | | Put a very small amount on my hands, smooth over all of my fingers. Use twice a day during an active outbreak. Use a couple of times a week thereafter, as prevention. I also use lots of moisturizer and wear gloves for cleaning tasks, etc. |
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| | Clobex review by 51 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Considerably Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | contact dermatitis |
| Dosage & duration: | | .05% BID (dosage frequency: prn) for the period of 2 years as needed |
| Other conditions: | | anxiety disorder |
| Other drugs taken: | | klonopin | | |
Reported Results |
| Benefits: | | Clobex was effective in resolving minor contact dermatitis. It soothed the irritation and lessened the dermatitis rather quickly however, it was also used for what was thought as dermatitis around the mouth. Use continued for six months with no results. The rash was exacerbated by heat and a diagnosis of MRSA was made. The Clobex, due to steroids in the cream, did not clear the lesions but rather made them worse. Use was discontinued and Bactroban and Septra DS was highly effective at clearing the infection. Have since had no need for Clobex and have used alternate methods for any incidental dermatitis that may occur. For those who chose to traditional medications, I can recommend Clobex for mild to severe dermatitis. I was satisfied with the results, except for the misdiagnosis of Skin MRSA, yet glad to know from experience, the difference between these two rashes. |
| Side effects: | | none |
| Comments: | | Had developed contact dermatitis on my arm; cause unknown. dermatologist prescibed Clobex .05% BID until condition cleared. The solution went on easily, non-greasy and calmed any itching. No bandaging was needed. The dermatitis cleared quickly and no follow-up was necessary. |
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Page last updated: 2013-05-18
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