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Clindamycin (Clindamycin Hydrochloride) - Side Effects and Adverse Reactions



The following reactions have been reported with the use of clindamycin.

Gastrointestinal: Abdominal pain, pseudomembranous colitis, esophagitis, nausea, vomiting and diarrhea (see WARNING box). The onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment (see WARNINGS).

Hypersensitivity Reactions: Generalized mild to moderate morbilliform-like (maculopapular) skin rashes are the most frequently reported adverse reactions. Vesiculobullous rashes, as well as urticaria, have been observed during drug therapy. Rare instances of erythema multiforme, some resembling Stevens-Johnson syndrome, and a few cases of anaphylactoid reactions have also been reported.

Skin and Mucous Membranes: Pruritus, vaginitis, and rare instances of exfoliative dermatitis have been reported. (See Hypersensitivity Reactions .)

Liver: Jaundice and abnormalities in liver function tests have been observed during clindamycin therapy.

Renal: Although no direct relationship of clindamycin to renal damage has been established, renal dysfunction as evidenced by azotemia, oliguria, and/or proteinuria has been observed in rare instances.

Hematopoietic: Transient neutropenia (leukopenia) and eosinophilia have been reported. Reports of agranulocytosis and thrombocytopenia have been made. No direct etiologic relationship to concurrent clindamycin therapy could be made in any of the foregoing.

Musculoskeletal: Rare instances of polyarthritis have been reported.


Below is a sample of reports where side effects / adverse reactions may be related to Clindamycin. The information is not vetted and should not be considered as verified clinical evidence.

Possible Clindamycin side effects / adverse reactions in 62 year old male

Reported by a pharmacist from United States on 2011-10-03

Patient: 62 year old male weighing 166.4 kg (366.1 pounds)

Reactions: Rash

Adverse event resulted in: hospitalization

Suspect drug(s):

Possible Clindamycin side effects / adverse reactions in 15 year old male

Reported by a health professional (non-physician/pharmacist) from Singapore on 2011-10-05

Patient: 15 year old male

Reactions: Periorbital Oedema

Suspect drug(s):
Ciprobay 100 Infusion 100 Mg/50 ML






Possible Clindamycin side effects / adverse reactions in 81 year old female

Reported by a consumer/non-health professional from United States on 2011-10-13

Patient: 81 year old female weighing 67.1 kg (147.7 pounds)

Reactions: Product Quality Issue, Confusional State, Fatigue, Activities of Daily Living Impaired, Dizziness

Adverse event resulted in: disablity

Suspect drug(s):

See index of all Clindamycin side effect reports >>

Drug label data at the top of this Page last updated: 2006-10-25

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