Clindamycin (Clindamycin Hydrochloride) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

The following reactions have been reported with the use of clindamycin.

Gastrointestinal: Abdominal pain, pseudomembranous colitis, esophagitis, nausea, vomiting and diarrhea (see WARNING box). The onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment (see WARNINGS).

Hypersensitivity Reactions: Generalized mild to moderate morbilliform-like (maculopapular) skin rashes are the most frequently reported adverse reactions. Vesiculobullous rashes, as well as urticaria, have been observed during drug therapy. Rare instances of erythema multiforme, some resembling Stevens-Johnson syndrome, and a few cases of anaphylactoid reactions have also been reported.

Skin and Mucous Membranes: Pruritus, vaginitis, and rare instances of exfoliative dermatitis have been reported. (See Hypersensitivity Reactions .)

Liver: Jaundice and abnormalities in liver function tests have been observed during clindamycin therapy.

Renal: Although no direct relationship of clindamycin to renal damage has been established, renal dysfunction as evidenced by azotemia, oliguria, and/or proteinuria has been observed in rare instances.

Hematopoietic: Transient neutropenia (leukopenia) and eosinophilia have been reported. Reports of agranulocytosis and thrombocytopenia have been made. No direct etiologic relationship to concurrent clindamycin therapy could be made in any of the foregoing.

Musculoskeletal: Rare instances of polyarthritis have been reported.

REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO CLINDAMYCIN

Possible Clindamycin side effects / adverse reactions in 86 year old male

Reported by a pharmacist from United States on 2007-01-02

Patient: 86 year old male weighing 89.0 kg (195.8 pounds)

Reactions: Dysphagia, Odynophagia

Adverse event resulted in: hospitalization, disablity

Suspect drug(s):
Clindamycin

Other drugs received by patient: Atenolol; Citalopram Hydrobromide; Furosemide; Glyburide; Hydrocortisone 1% Ointment; Hydroxyzine Pamoate; Loratadine; Omeprazole; Terazosin HCL

Possible Clindamycin side effects / adverse reactions in 54 year old female

Reported by a consumer/non-health professional from United States on 2007-01-05

Patient: 54 year old female weighing 107.3 kg (236.1 pounds)

Reactions: Weight Increased, Diarrhoea, Staphylococcal Infection, Clostridial Infection

Suspect drug(s):
Ciprofloxacin
    Indication: Staphylococcal Infection

Clindamycin
    Indication: Staphylococcal Infection
    Start date: 2006-11-01
    End date: 2006-11-01

Lotronex
    Dosage: 1mg per day
    Administration route: Oral
    Indication: Irritable Bowel Syndrome
    Start date: 2006-06-01
    End date: 2006-12-15

Other drugs received by patient: Liquibid D; Avandia; Metformin HCL; Crestor; Protonix; Estradiol; Lexapro; Centrum Silver; Aspirin; Imitrex; Mycolog

Possible Clindamycin side effects / adverse reactions in 8 month old male

Reported by a consumer/non-health professional from United States on 2007-01-09

Patient: 8 month old male weighing 9.5 kg (21.0 pounds)

Reactions: Malaise, Vomiting, Drug Exposure VIA Breast Milk, Pyrexia, Pallor, Lethargy

Suspect drug(s):
Clindamycin
    Dosage: 2% 1x day vag
    Indication: Infection
    Start date: 2006-01-06
    End date: 2006-01-06

Clindamycin
    Dosage: 2% 1x day vag
    Indication: Infection
    Start date: 2006-01-09
    End date: 2006-01-09

Other drugs received by patient: Clindamycin