Adverse Reactions Section
The following reactions have been reported with the use of clindamycin.
Abdominal pain, pseudomembranous colitis, esophagitis, nausea, vomiting, and diarrhea (see
box). The onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment (see
Generalized mild to moderate morbilliform-like (maculopapular) skin rashes are the most frequently reported adverse reactions.
Vesiculobullous rashes, as well as urticaria, have been observed during drug therapy. Rare instances of erythema multiforme, some resembling Stevens-Johnson syndrome, and a few cases of anaphylactoid reactions have also been reported.
Skin and Mucous Membranes:
Pruritus, vaginitis, and rare instances of exfoliative dermatitis have been reported. (See
Jaundice and abnormalities in liver function tests have been observed during clindamycin therapy.
Although no direct relationship of clindamycin to renal damage has been established, renal dysfunction as evidenced by azotemia, oliguria, and/or proteinuria has been observed in rare instances.
Transient neutropenia (leukopenia) and eosinophilia have been reported. Reports of agranulocytosis and thrombocytopenia have been made. No direct etiologic relationship to concurrent clindamycin therapy could be made in any of the foregoing.
Rare instances of polyarthritis have been reported.