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Cleocin (Clindamycin Hydrochloride) - Side Effects and Adverse Reactions



The following reactions have been reported with the use of clindamycin.

Gastrointestinal: Abdominal pain, pseudomembranous colitis, esophagitis, nausea, vomiting and diarrhea (see WARNING box). The onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment (see WARNINGS).

Hypersensitivity Reactions: Generalized mild to moderate morbilliform-like (maculopapular) skin rashes are the most frequently reported adverse reactions. Vesiculobullous rashes, as well as urticaria, have been observed during drug therapy. Rare instances of erythema multiforme, some resembling Stevens-Johnson syndrome, and a few cases of anaphylactoid reactions have also been reported.

Skin and Mucous Membranes: Pruritus, vaginitis, and rare instances of exfoliative dermatitis have been reported. (See Hypersensitivity Reactions .)

Liver: Jaundice and abnormalities in liver function tests have been observed during clindamycin therapy.

Renal: Although no direct relationship of clindamycin to renal damage has been established, renal dysfunction as evidenced by azotemia, oliguria, and/or proteinuria has been observed in rare instances.

Hematopoietic: Transient neutropenia (leukopenia) and eosinophilia have been reported. Reports of agranulocytosis and thrombocytopenia have been made. No direct etiologic relationship to concurrent clindamycin therapy could be made in any of the foregoing.

Musculoskeletal: Rare instances of polyarthritis have been reported.


Below is a sample of reports where side effects / adverse reactions may be related to Cleocin. The information is not vetted and should not be considered as verified clinical evidence.

Possible Cleocin side effects / adverse reactions in 16 year old male

Reported by a consumer/non-health professional from United States on 2012-07-19

Patient: 16 year old male weighing 63.5 kg (139.7 pounds)

Reactions: Clostridium Difficile Colitis

Suspect drug(s):

Possible Cleocin side effects / adverse reactions in 72 year old female

Reported by a physician from United States on 2012-08-06

Patient: 72 year old female

Reactions: Drug Hypersensitivity

Suspect drug(s):
    Dosage: unk

Codeine Sulfate
    Dosage: unk

    Dosage: unk

    Dosage: unk

See index of all Cleocin side effect reports >>

Drug label data at the top of this Page last updated: 2009-10-23

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