Cleocin (Clindamycin Hydrochloride) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

The following reactions have been reported with the use of clindamycin.

Gastrointestinal:    Abdominal pain, pseudomembranous colitis, esophagitis, nausea, vomiting and diarrhea (see WARNING box). The onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment (see WARNINGS).

Hypersensitivity Reactions:    Generalized mild to moderate morbilliform-like (maculopapular) skin rashes are the most frequently reported adverse reactions. Vesiculobullous rashes, as well as urticaria, have been observed during drug therapy. Rare instances of erythema multiforme, some resembling Stevens-Johnson syndrome, and a few cases of anaphylactoid reactions have also been reported.

Skin and Mucous Membranes:    Pruritus, vaginitis, and rare instances of exfoliative dermatitis have been reported. (See Hypersensitivity Reactions.)

Liver:    Jaundice and abnormalities in liver function tests have been observed during clindamycin therapy.

Renal:    Although no direct relationship of clindamycin to renal damage has been established, renal dysfunction as evidenced by azotemia, oliguria, and/or proteinuria has been observed in rare instances.

Hematopoietic:    Transient neutropenia (leukopenia) and eosinophilia have been reported. Reports of agranulocytosis and thrombocytopenia have been made. No direct etiologic relationship to concurrent clindamycin therapy could be made in any of the foregoing.

Musculoskeletal:    Rare instances of polyarthritis have been reported.

REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO CLEOCIN

Possible Cleocin side effects / adverse reactions in 48 year old female

Reported by a consumer/non-health professional from United States on 2009-06-10

Patient: 48 year old female weighing 120.2 kg (264.4 pounds)

Reactions: LIP Swelling, Swelling Face, Rash, Swollen Tongue, Pruritus Generalised, LIP Blister, Tongue Disorder, Swelling, Nasal Disorder

Suspect drug(s):
Cleocin

Other drugs received by patient: Aygestin

Possible Cleocin side effects / adverse reactions in 85 year old female

Reported by a consumer/non-health professional from United States on 2009-08-13

Patient: 85 year old female weighing 78.0 kg (171.6 pounds)

Reactions: Frequent Bowel Movements, Nausea, Diarrhoea, Discomfort

Adverse event resulted in: life threatening event, hospitalization

Suspect drug(s):
Cleocin

Possible Cleocin side effects / adverse reactions in 77 year old female

Reported by a pharmacist from United States on 2009-10-09

Patient: 77 year old female weighing 101.6 kg (223.5 pounds)

Reactions: Hypersensitivity, Drug Ineffective, Drug Interaction, Pyrexia

Adverse event resulted in: hospitalization

Suspect drug(s):
Cleocin

Glipizide

Benzylpenicillin and Benzylpenicillin Potassium and Benzylpenicillin S

Other drugs received by patient possibly interacting with the suspect drug:
Zyvox
    Dosage: unk, q12h
    Administration route: Oral
    Indication: Enterococcal Infection
    Start date: 2009-09-04
    End date: 2009-09-01

Zyvox
    Indication: Pseudomonas Infection

Omeprazole
    Dosage: 40 mg, daily
    Start date: 2009-09-03

Cranberry/ Vitamin C/vitamin E
    Dosage: unk
    Administration route: Oral
    Start date: 2009-09-07

Other drugs received by patient: Doripenem; Vancomycin