Claritin (Loratadine) - Summary

CLARITIN SUMMARY

Claritin (Loratadine) is an antihistamine.
Claritin (Loratadine) is used to relieve symproms of hay fever and allergy, including sneezing, runny nose, and red, itchy and tearing eyes.
It works by blocking histamine, a substance in the body that causes allergic symptoms. Loratadine may cause less drowsiness than other antihistamines.

CLARITIN is indicated for the relief of nasal and non-nasal symptoms of seasonal allergic rhinitis and for the treatment of chronic idiopathic urticaria in patients 2 years of age or older.

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NEWS HIGHLIGHTS

Published Studies Related to Claritin (Loratadine)

Petasol butenoate complex (Ze 339) relieves allergic rhinitis-induced nasal obstruction more effectively than desloratadine. [2011.06]
BACKGROUND: Allergic rhinitis symptoms of itching, sneezing, rhinorrhea, and nasal obstruction significantly decrease patients' quality of life. Compared with histamine and leukotriene receptor antagonists, the petasol butenoate complex Ze 339 displays pharmacologically distinct properties. In vitro it inhibits the biosynthesis of leukotrienes and mediator release from activated eosinophils. OBJECTIVE: This study aimed to assess the efficacy and mode of action of Ze 339, desloratadine, and placebo on allergic rhinitis symptoms, nasal airflow, and local mediator levels after unilateral nasal allergen provocation... CONCLUSION: When compared with desloratadine and placebo, Ze 339 shows better efficacy in relieving nasal obstruction symptoms and inhibiting critical components of the chemokine network and as such represents a novel symptomatic and possible prophylactic treatment for allergic rhinitis. Copyright (c) 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

Use of montelukast alone or in combination with desloratadine or levocetirizine in patients with persistent allergic rhinitis. [2011]
alone or combinations of antihistamine and montelukast... CONCLUSION: Montelukast alone or in combination with antihistamines gave a

Petasol butenoate complex (Ze 339) relieves allergic rhinitis-induced nasal obstruction more effectively than desloratadine. [2011]
local mediator levels after unilateral nasal allergen provocation... CONCLUSION: When compared with desloratadine and placebo, Ze 339 shows better

The effectiveness of levocetirizine and desloratadine in up to 4 times conventional doses in difficult-to-treat urticaria. [2010.03]
BACKGROUND: H(1)-antihistamines are first line treatment of chronic urticaria, but many patients do not get satisfactory relief with recommended doses. European guidelines recommend increased antihistamine doses of up to 4-fold. OBJECTIVE: To provide supportive evidence for the European guidelines... CONCLUSION: Increasing the dosage of levocetirizine and desloratadine up to 4-fold improves chronic urticaria symptoms without compromising safety in approximately three quarters of patients with difficult-to-treat chronic urticaria.

Onset of action of loratadine/montelukast in seasonal allergic rhinitis patients exposed to grass pollen. [2010]
Given the impact of allergic rhinitis (AR) on quality of life, it is important that AR medications have rapid onset of symptom relief. The objective of this study was to determine the onset of action of loratadine (CAS 79794-75-5)/montelukast (CAS 151767-02-1) 10 mg/10 mg (L/M) versus placebo in seasonal AR (SAR) subjects.

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Clinical Trials Related to Claritin (Loratadine)

Evaluation of Loratadine for Prevention of Pegfilgrastim-Induced Pain [Recruiting]
The purpose of this study is to determine the incidence of pegfilgrastim-induced back and leg pain and to determine whether the antihistamine loratadine can prevent pegfilgrastim-induced back and leg pain.

Post Approval Pharmacokinetic Study of Loratadine in Japanese Pediatric and Adult Patients (Study P05539) [Completed]

Observation of Use of Claritin (Loratadine) Tablet, RediTabs, and Dry Syrup in Children (Study P05834)(COMPLETED) [Completed]
The purpose of this study is to collect information on unexpected adverse reactions (ADRs), how often ADRs occur, and factors that can affect the safety and effectiveness of Claritin (loratadine) when used in children. Patients will be observed while they are taking Claritin, and ADRs and symptom scores will be recorded. At the end of treatment, improvement in symptoms will be recorded. Post-marketing surveys are not considered applicable clinical trials and thus the results of this survey will not be posted at its conclusion. The results will be submitted to public health officials as required by applicable national and international laws.

The Efficacy of Claritin in Healthy Subjects [Completed]

Bioequivalnce Study of Loratadine / Pseudoephedrine Sulfate 10/ 240 mg Extended-Release Tablets Under Fasting Conditions [Completed]
The objective of this study was to compare the single-dose relative bioavailability of Ranbaxy and Schering (Claritin-D® 24 hour) Loratadine 10mg /Pseudoephedrine Sulfate 240 mg Extended-Release Tablets, in a fully replicated design, under fasting conditions.

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Reports of Suspected Claritin (Loratadine) Side Effects

Drug Ineffective (66),  Overdose (34),  NO Therapeutic Response (26),  Dizziness (18),  Headache (16),  Accidental Overdose (12),  Feeling Abnormal (10),  Hypersensitivity (9),  Drug Effect Decreased (9),  Pain in Extremity (9), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Claritin review by 30 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		Seasonal Allergies
Dosage & duration:		10 mg taken 1 per day for the period of as needed
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		After 4 to 5 days on the medication, Claritin greatly reduces itchiness, sneezing, scratchy throat associated with seasonal allergies
Side effects:		I experienced absolutely no adverse side effects. None whatsoever. No side effects at all. It does not take me 50 words to explain there were no side effects, but there were no side effects.
Comments:		Take 1 Claritin tablet every day during allergy season. I take the dose every moring. Again, 1 pill per day each morning during allergy season

Claritin review by 27 year old female patient
		Rating
Overall rating:
Effectiveness:		Moderately Effective
Side effects:		Moderate Side Effects
		Treatment Info
Condition / reason:		chronic sinus congestion
Dosage & duration:		1 pill every 4-6 hours or as needed taken as prescribed/when needed for the period of off and on until sinuses cleared
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		The drug cleared my sinuses but took some time to become effective after use. The effect only lasted about half a day. I would take this off and on for about 3 months.
Side effects:		I felt like I was hopped up the whole time. My skin would feel crawly and I would be generally jittery and not able to focus. I lost concentration and felt high the whole time. It also made me feel really dehydrated.
Comments:		The medication was for my use during a sinus infection at first to help relieve congestion. When the sinus infection subsided I still had congestion fairly often so was prescribed to take is as needed. I would usually take one in the morning when it was worst. I stopped after a few months due to side effects and made diet changes to relieve it.

Claritin review by 40 year old female patient
		Rating
Overall rating:
Effectiveness:		Ineffective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		allergies sneezing , watery runny nose
Dosage & duration:		10mg taken 1 every 24 hrs. for the period of 2 days
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		none
Side effects:		none
Comments:		all day sneezing and continually runny nose secondary to seasonal allergy. This medication stopped the sneezing for about 4 hrs. Then it resumed as did the continuous runny nose. Directions say take 1 only every 24 hrs. I won't buy this medication again. No noticeable side effects at all except it certainly didn't work at all.