CLARIPEL CREAM SUMMARY
Hydroquinone is 1,4-benzenediol. Hydroquinone is structurally related to monobenzone. Hydroquinone occurs as fine, white needles. The drug is freely soluble in water and in alcohol and has a pKa of 9.96. Topical application of hydroquinone produces a reversible depigmentation of the skin by inhibition of the enzymatic oxidation of tyrosine to 3-(3,4-dihydroxyphenyl) alanine (dopa) and suppression of other melanocyte metabolic processes.
Claripel Cream is indicated for the gradual treatment of ultraviolet induced dyschromia and discoloration resulting from the use of oral contraceptives, pregnancy, hormone replacement therapy, or skin trauma.
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CLARIPEL CREAM NEWS HIGHLIGHTS
Published Studies Related to Claripel Cream (Hydroquinone)
A randomized controlled trial of the efficacy and safety of a fixed triple combination (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%) compared with hydroquinone 4% cream in Asian patients with moderate to severe melasma. [2008.09]
Comparative evaluation of beneficiary effects of priming agents (2% hydroquinone and 0.025% retinoic acid) in the treatment of melasma with glycolic acid peels. [2008.08]
A randomized controlled trial of the efficacy and safety of a fixed triple combination (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%) compared with hydroquinone 4% cream in Asian patients with moderate to severe melasma. [2008.06.28]
A hydroquinone formulation with increased stability and decreased potential for irritation. [2007.06]
A comparison of triple combination cream and hydroquinone 4% cream for the treatment of moderate to severe facial melasma. [2007.03]
Clinical Trials Related to Claripel Cream (Hydroquinone)
Salicylic Acid Peels Combined With 4% Hydroquinone in the Treatment of Moderate to Severe Melasma in Hispanic Women [Active, not recruiting]
Exercise Training in Obesity-Prone Black and White Women [Completed]
Efficacy and Safety of Therapy With Tri-LumaŽ Cream in Sequence With Glycolic Acid Peels for Melasma [Completed]
Effectiveness of Low Dose Complex B-Vitamins on Homocysteine Lowering Among Chinese Elderly--Randomized Control Trial (RCT) [Recruiting]
A Comparison of Hemorrhagic and Ischemic Strokes Among Blacks and Whites [Active, not recruiting]
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CLARIPEL CREAM PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 2 ratings/reviews, Claripel Cream has an overall score of 6. The effectiveness score is 7 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
| | Claripel Cream review by 45 year old female patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Moderately Effective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | age spots |
| Dosage & duration: | | 2x morning and night (dosage frequency: 1xat night) for the period of 1 year |
| Other conditions: | | large pores, redness,dry patches, sun damage |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | Some of the larger brown spots faded. Skin seemed smoother. |
| Side effects: | | Caused irritation and more redness. Skin was very sensitive. Some dryness. Most suncreens caused burning and itching. |
| Comments: | | Told to use in morning and night all over face. This proved to be too much for my skin so I tried just at bedtime. Need to wait after washing face for skin to dry and settle. Was also suggested to try different face cream moisturiser and sunscreen during the day. Sunscreen a must. Also used some anti-wrinkle cream with retinoid... |
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| | Claripel Cream review by 23 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Considerably Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | pigmentation |
| Dosage & duration: | | 2% (dosage frequency: 1x daily) for the period of 4 months |
| Other conditions: | | Redness |
| Other drugs taken: | | Vitamin C | | |
Reported Results |
| Benefits: | | Minimized pigmentation if not absolved them altogether. Good results for both hypo- and hyper- pigmentation. |
| Side effects: | | So far none, however there could be future side effects. I've read recent studies that have come out stating the carcinogenic nature of this drug. I would not advise anyone else to use this drug since there are natural alternatives. |
| Comments: | | Placed the cream daily on the pigmented lesions for 4 months. I have stopped using this drug altogether after reading the reports. |
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Page last updated: 2008-11-02
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