Claripel Cream (Hydroquinone) - Summary

CLARIPEL CREAM SUMMARY

Hydroquinone is 1,4-benzenediol. Hydroquinone is structurally related to monobenzone. Hydroquinone occurs as fine, white needles. The drug is freely soluble in water and in alcohol and has a pKa of 9.96. Topical application of hydroquinone produces a reversible depigmentation of the skin by inhibition of the enzymatic oxidation of tyrosine to 3-(3,4-dihydroxyphenyl) alanine (dopa) and suppression of other melanocyte metabolic processes.

Claripel Cream is indicated for the gradual treatment of ultraviolet induced dyschromia and discoloration resulting from the use of oral contraceptives, pregnancy, hormone replacement therapy, or skin trauma.

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NEWS HIGHLIGHTS

Published Studies Related to Claripel Cream (Hydroquinone)

Further enhancement of facial appearance with a hydroquinone skin care system plus tretinoin in patients previously treated with botulinum toxin Type A. [2011.07]
BACKGROUND: A hydroquinone (HQ) skin care system has been designed for use in conjunction with nonsurgical procedures. OBJECTIVE: The authors evaluate the efficacy of this system plus tretinoin for improving facial appearance in comparison to a standard skin care regimen in users of botulinum toxin Type A (BoNT-A)... CONCLUSIONS: Adjunctive use of the HQ system plus tretinoin can further enhance the improvements in facial appearance attained with BoNT-A. Applying the HQ system plus tretinoin offers multiple clinical benefits over standard skin care, including significantly greater improvements in fine lines/wrinkles and hyperpigmentation.

Evaluation of a kojic acid, emblica extract, and glycolic acid formulation compared with hydroquinone 4% for skin lightening. [2010.09]
Hydroquinone has been the standard prescription agent for skin lightening; however, its use recently has become controversial. Hydroquinone is banned in Europe and parts of Asia because of potential long-term consequences, including carcinogenesis when orally consumed... Thus this novel skin lightening preparation is an alternative to hydroquinone 4% for participants with mild to moderate facial dyschromia.

Treating photodamage of the decolletage area with a novel copper zinc malonate complex plus hydroquinone and tretinoin. [2010.03]
There has been a proliferation of treatments for facial rejuvenation but, curiously, the use of such treatments on other areas of the body has not been widely investigated. The clinical effects of treating photodamaged skin of the neck and anterior chest area (decolletage) with a proprietary copper zinc malonate lotion and a proprietary 4% hydroquinone cream (twice daily), plus tretinoin cream (once daily), were evaluated in 42 females in a 24-week investigator-blind randomized study...

Benefits of using a hydroquinone/tretinoin skin care system in patients undergoing intense pulsed light therapy for photorejuvenation: a placebo-controlled study. [2009.09]
A hydroquinone/tretinoin (HQ/tret) skin care system designed for use with non-surgical facial rejuvenation procedures has recently become available. In this observer-masked study, 36 patients with moderate-to-severe wrinkling of the skin around the eyes and lips were randomly assigned to use either the 4% hydroquinone/0.05% tretinoin skin care system or placebo products, each day for 90 days...

A randomized controlled trial of the efficacy and safety of a fixed triple combination (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%) compared with hydroquinone 4% cream in Asian patients with moderate to severe melasma. [2008.09]
BACKGROUND: Melasma is an acquired, chronic hypermelanosis for which therapy remains a challenge. OBJECTIVES: To compare the efficacy and safety of a triple combination [TC: fluocinolone acetonide 0.01%, hydroquinone (HQ) 4%, tretinoin 0.05%] vs. HQ 4% after 8 weeks of treatment of moderate to severe facial melasma in Asian patients... CONCLUSIONS: Efficacy in Asians and patient satisfaction were superior with the fixed TC than with HQ 4%.

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Clinical Trials Related to Claripel Cream (Hydroquinone)

Clinical Trial of Hydroquinone Versus Miconazol in Melasma [Recruiting]
Melasma is an acquired discoloration of the skin characterized by brown colour changes commonly on the face. The duration of this double-blind clinical trial will be 12 weeks. The control group will receive treatment with topical Hydroquinone (4%), and the other group topical miconazole. Miconazol has antimelanotic properties and can be used as treatment for melasma patients. The estimated number of subjects to be recruited and randomized for the study is at least 30. The purpose of this study is determine if there is a difference in the effectiveness of these two agents. Melasma Area and Severity Index (MASI) score will be assessed at the beginning of the study and at weeks 4, 8, and 12. Photographs, colorimetry and histological assessment will be also evaluated. Occurrence of adverse effects will also be recorded.

Azelaic Acid Versus Hydroquinone in Melasma [Recruiting]

Salicylic Acid Peels Combined With 4% Hydroquinone in the Treatment of Moderate to Severe Melasma in Hispanic Women [Active, not recruiting]
This study will enroll 20 adult Hispanic women. Participants will apply 4% hydroquinone cream twice daily to affected areas on the face for 14 weeks and half the face will be peeled with 20-30% salicylic acid every two weeks for a total of 4 peels. The first two peels will be 20% salicylic acid and the second two peels will be with 30% salicylic acid. The purpose of the study will be to evaluate the safety and efficacy of salicylic acid combined with 4% hydroquinone versus 4% hydroquinone alone.

Effectiveness of Low Dose Complex B-Vitamins on Homocysteine Lowering Among Chinese Elderly--Randomized Control Trial (RCT) [Recruiting]
The purpose of this study is to evaluate whether low dose complex B-vitamins (folic acid,vitamin B6 and vitamin B12) can lower the risk of developing hyperhomocysteinemia in an apparently healthy population with low folate/B12 and high Hcy status.

Bone Health in Pregnancy [Recruiting]
Women between the ages of 19 and 40 are needed for a study that looks at the effect of calcium and vitamin D supplementation on bone health during pregnancy in black and white women. Study subjects will be divided into three groups. Each group will take 2 study supplements each day, the supplement will be calcium, vitamin D or placebo (a pill with neither calcium nor vitamin D). The study involves five visits to the Children's Hospital of Oakland Research Institute; each visit will be 1-2 hours in length. There are 3 study visits during pregnancy and 2 in the first year after delivery. At each visit you will have your blood drawn and be asked questions about what you eat and what type of activities you do. At visit 16 and 36 weeks and 4 and 12 months postpartum you will have your bone density measured. You will be paid $235 for completing the study.

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PATIENT REVIEWS / RATINGS / COMMENTS

Claripel Cream review by 32 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		hyperpigmatation
Dosage & duration:		fluo. acet. 0.01%, hydro4%, tret 0.5% (dosage frequency: one 20 gram tube every eight weeks) for the period of once per night
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		hydeoquione mitigated uneven tone of face as well as freckles. It additionally left the skin with a taught texture. My skin seemd to look 10 years younger
Side effects:		I wore 60 SPF everyday even in the winter to avoid any sun damage. I did not experience any side affects.
Comments:		I was seen by my doctor and he thought the medication would be the best route to take for my condition. I was told to put it on my face three time a week at night. However- I used it every night

Claripel Cream review by 23 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		pigmentation
Dosage & duration:		2% (dosage frequency: 1x daily) for the period of 4 months
Other conditions:		Redness
Other drugs taken:		Vitamin C
		Reported Results
Benefits:		Minimized pigmentation if not absolved them altogether. Good results for both hypo- and hyper- pigmentation.
Side effects:		So far none, however there could be future side effects. I've read recent studies that have come out stating the carcinogenic nature of this drug. I would not advise anyone else to use this drug since there are natural alternatives.
Comments:		Placed the cream daily on the pigmented lesions for 4 months. I have stopped using this drug altogether after reading the reports.

Claripel Cream review by 43 year old female patient
		Rating
Overall rating:
Effectiveness:		Ineffective
Side effects:		Moderate Side Effects
		Treatment Info
Condition / reason:		hyperpigmentation
Dosage & duration:		4% cream (dosage frequency: two a day) for the period of four weeks
Other conditions:		some acne
Other drugs taken:		none
		Reported Results
Benefits:		I did not have any benefits by using hydroquinone
Side effects:		I had some light hyperpigmentations, and hydroquinone made my hyperpigmentation darker.
Comments:		My dermatologist prescribed hydroquinone 4% cream to helped me with a light hyperpigmentation problem. However, hydroquinone did not work at all. I had the opposite effect. My hyperpigmentation became darker.