Claripel Cream (Hydroquinone) - Summary

CLARIPEL CREAM SUMMARY

Hydroquinone is 1,4-benzenediol. Hydroquinone is structurally related to monobenzone. Hydroquinone occurs as fine, white needles. The drug is freely soluble in water and in alcohol and has a pKa of 9.96. Topical application of hydroquinone produces a reversible depigmentation of the skin by inhibition of the enzymatic oxidation of tyrosine to 3-(3,4-dihydroxyphenyl) alanine (dopa) and suppression of other melanocyte metabolic processes.

Claripel Cream is indicated for the gradual treatment of ultraviolet induced dyschromia and discoloration resulting from the use of oral contraceptives, pregnancy, hormone replacement therapy, or skin trauma.

See all indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Claripel Cream (Hydroquinone)

Benefits of using a hydroquinone/tretinoin skin care system in patients undergoing intense pulsed light therapy for photorejuvenation: a placebo-controlled study. [2009.09]
A hydroquinone/tretinoin (HQ/tret) skin care system designed for use with non-surgical facial rejuvenation procedures has recently become available. In this observer-masked study, 36 patients with moderate-to-severe wrinkling of the skin around the eyes and lips were randomly assigned to use either the 4% hydroquinone/0.05% tretinoin skin care system or placebo products, each day for 90 days...

A randomized controlled trial of the efficacy and safety of a fixed triple combination (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%) compared with hydroquinone 4% cream in Asian patients with moderate to severe melasma. [2008.09]
BACKGROUND: Melasma is an acquired, chronic hypermelanosis for which therapy remains a challenge. OBJECTIVES: To compare the efficacy and safety of a triple combination [TC: fluocinolone acetonide 0.01%, hydroquinone (HQ) 4%, tretinoin 0.05%] vs. HQ 4% after 8 weeks of treatment of moderate to severe facial melasma in Asian patients... CONCLUSIONS: Efficacy in Asians and patient satisfaction were superior with the fixed TC than with HQ 4%.

Comparative evaluation of beneficiary effects of priming agents (2% hydroquinone and 0.025% retinoic acid) in the treatment of melasma with glycolic acid peels. [2008.08]
BACKGROUND: Chemical peels have become a popular modality in the treatment of melasma. The most disturbing side effect of this procedure is postinflammatory hyperpigmentation. This may be minimized with the help of priming agents. Because there is a paucity of such studies, this study was taken up to evaluate the beneficial effects of hydroquinone versus tretinoin as priming agents in treatment of melasma with glycolic acid peels... CONCLUSIONS: Results are better with hydroquinone as priming agent compared to tretinoin in enhancing the results with glycolic acid peels in melasma and in decreasing postpeel postinflammatory hyperpigmentation.

A randomized controlled trial of the efficacy and safety of a fixed triple combination (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%) compared with hydroquinone 4% cream in Asian patients with moderate to severe melasma. [2008.06.28]
Background Melasma is an acquired, chronic hypermelanosis for which therapy remains a challenge... Conclusions Efficacy in Asians and patient satisfaction were superior with the fixed TC than with HQ 4%.

A hydroquinone formulation with increased stability and decreased potential for irritation. [2007.06]
BACKGROUND: Long-term treatment with a high-strength hydroquinone (HQ) cream (usually 4% HQ) is the mainstay therapy for hyperpigmentation disorders. Instability and high potential for irritancy hinders patient compliance. A new 4% HQ preparation has been designed with an innovative antioxidant for stability and a biomimetic of an herbal extract for skin calming. AIMS: To investigate the activity, stability, and irritancy of a new HQ cream... CONCLUSION: Based on its improved stability, lower irritancy, and activity in skin lightening, the new approach to the formulation of 4% HQ may improve therapeutic outcomes by improving patient compliance to dosing.

more studies >>

Clinical Trials Related to Claripel Cream (Hydroquinone)

Azelaic Acid Versus Hydroquinone in Melasma [Recruiting]

Salicylic Acid Peels Combined With 4% Hydroquinone in the Treatment of Moderate to Severe Melasma in Hispanic Women [Active, not recruiting]
This study will enroll 20 adult Hispanic women. Participants will apply 4% hydroquinone cream twice daily to affected areas on the face for 14 weeks and half the face will be peeled with 20-30% salicylic acid every two weeks for a total of 4 peels. The first two peels will be 20% salicylic acid and the second two peels will be with 30% salicylic acid. The purpose of the study will be to evaluate the safety and efficacy of salicylic acid combined with 4% hydroquinone versus 4% hydroquinone alone.

Exercise Training in Obesity-Prone Black and White Women [Completed]
Overweight premenopausal Black and White women are randomized to either diet-only, diet+aerobic or diet+resistance exercise training. Diet/behavior intervention, with or without the aerobic or resistance exercise training, will be provided throughout the 18 months of study. Major outcomes will include measures of perceived and physiologic difficulty of exercise (cardiac, ventilatory, electromyographic responses to standardized exercise tasks); aerobic fitness; strength fitness; and spontaneous free-living energy expenditure (all derived from doubly labeled water). The results will provide insight into the effectiveness of, and the mechanisms by which, different types of exercise training can improve physical fitness, spontaneous engagement in physical activities of daily living and, in turn, weight-loss maintenance.

Efficacy and Safety of Therapy With Tri-Luma® Cream in Sequence With Glycolic Acid Peels for Melasma [Completed]
To determine the effectiveness and safety of sequential therapy with of Tri-Luma® Cream and a series of Glycolic Acid peels in treatment of moderate to severe melasma.

Effectiveness of Low Dose Complex B-Vitamins on Homocysteine Lowering Among Chinese Elderly--Randomized Control Trial (RCT) [Recruiting]
The purpose of this study is to evaluate whether low dose complex B-vitamins (folic acid,vitamin B6 and vitamin B12) can lower the risk of developing hyperhomocysteinemia in an apparently healthy population with low folate/B12 and high Hcy status.

more trials >>

PATIENT REVIEWS / RATINGS / COMMENTS

Claripel Cream review by 24 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		pigmentation
Dosage & duration:		4 % (dosage frequency: once a day) for the period of 3 month
Other conditions:		large pore, dryness
Other drugs taken:		none
		Reported Results
Benefits:		Minimized pigmentation. Some of my acne scar has faded but some still remain.
Side effects:		peeling. It has made my skin really dry. Caused irritation and more redness. Skin was very sensitive
Comments:		once a day at night time for a period of 3 month. I wear sunscreen every day. However, I have stopped using it after reading the reports that it has harmful side effects in the long term.

Claripel Cream review by 45 year old female patient
		Rating
Overall rating:
Effectiveness:		Moderately Effective
Side effects:		Moderate Side Effects
		Treatment Info
Condition / reason:		age spots
Dosage & duration:		2x morning and night (dosage frequency: 1xat night) for the period of 1 year
Other conditions:		large pores, redness,dry patches, sun damage
Other drugs taken:		none
		Reported Results
Benefits:		Some of the larger brown spots faded. Skin seemed smoother.
Side effects:		Caused irritation and more redness. Skin was very sensitive. Some dryness. Most suncreens caused burning and itching.
Comments:		Told to use in morning and night all over face. This proved to be too much for my skin so I tried just at bedtime. Need to wait after washing face for skin to dry and settle. Was also suggested to try different face cream moisturiser and sunscreen during the day. Sunscreen a must. Also used some anti-wrinkle cream with retinoid...

Claripel Cream review by 44 year old male patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Severe Side Effects
		Treatment Info
Condition / reason:		reaction with benzoyl peroxide
Dosage & duration:		twice daily (dosage frequency: twice daily) for the period of 10 days
Other conditions:		acne scarring
Other drugs taken:		benzoyl peroxide
		Reported Results
Benefits:		The product did lighten the skin, which was the desired results. The was some redness and skin warming, but those side effects were tolerable.
Side effects:		I had an allergic reaction when used with benzoyl peroxide. My pores became enlarged, and were plugged with blackheads. My research found that when used with benzoyl peroxide, staining and pore enlargement might be a side effect, which I did suffer.
Comments:		I was prescribed hydroquinone to lighten/even my skin tone prior to laser treatment of scarring due to acne. About two days in to the treatment, I noticed the pore enlargement and staining. After 10 days, I discontinued the treatment due to the side effects.