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Clarinex (Desloratadine) - Summary

 
 



CLARINEX SUMMARY

CLARINEX (desloratadine) Tablets are light blue, round, film coated tablets containing 5 mg desloratadine, an antihistamine, to be administered orally.

CLARINEX is indicated for the following:

Seasonal Allergic Rhinitis: CLARINEX is indicated for the relief of the nasal and non-nasal symptoms of seasonal allergic rhinitis in patients 2 years of age and older.

Perennial Allergic Rhinitis: CLARINEX is indicated for the relief of the nasal and non-nasal symptoms of perennial allergic rhinitis in patients 6 months of age and older.

Chronic Idiopathic Urticaria: CLARINEX is indicated for the symptomatic relief of pruritus, reduction in the number of hives, and size of hives, in patients with chronic idiopathic urticaria 6 months of age and older.


See all Clarinex indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Clarinex (Desloratadine)

Petasol butenoate complex (Ze 339) relieves allergic rhinitis-induced nasal obstruction more effectively than desloratadine. [2011.06]
BACKGROUND: Allergic rhinitis symptoms of itching, sneezing, rhinorrhea, and nasal obstruction significantly decrease patients' quality of life. Compared with histamine and leukotriene receptor antagonists, the petasol butenoate complex Ze 339 displays pharmacologically distinct properties. In vitro it inhibits the biosynthesis of leukotrienes and mediator release from activated eosinophils. OBJECTIVE: This study aimed to assess the efficacy and mode of action of Ze 339, desloratadine, and placebo on allergic rhinitis symptoms, nasal airflow, and local mediator levels after unilateral nasal allergen provocation... CONCLUSION: When compared with desloratadine and placebo, Ze 339 shows better efficacy in relieving nasal obstruction symptoms and inhibiting critical components of the chemokine network and as such represents a novel symptomatic and possible prophylactic treatment for allergic rhinitis. Copyright (c) 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

Use of montelukast alone or in combination with desloratadine or levocetirizine in patients with persistent allergic rhinitis. [2011.01]
BACKGROUND: We assessed the course of treatment in patients with persistent allergic rhinitis (AR) treated with montelukast, levocetirizine, or desloratadine alone or combinations of antihistamine and montelukast... CONCLUSION: Montelukast alone or in combination with antihistamines gave a gradual increase in nasal symptom improvement within 6 weeks of treatment in patients with persistent AR.

Use of montelukast alone or in combination with desloratadine or levocetirizine in patients with persistent allergic rhinitis. [2011]
alone or combinations of antihistamine and montelukast... CONCLUSION: Montelukast alone or in combination with antihistamines gave a

Petasol butenoate complex (Ze 339) relieves allergic rhinitis-induced nasal obstruction more effectively than desloratadine. [2011]
local mediator levels after unilateral nasal allergen provocation... CONCLUSION: When compared with desloratadine and placebo, Ze 339 shows better

Efficacy of Desloratadine in Persistent Allergic Rhinitis - A GALEN Study. [2010.06.18]
Background: The ARIA (Allergic Rhinitis and its Impact on Asthma) guidelines proposed a classification for allergic rhinitis based on the duration of symptoms (intermittent or persistent) rather than on the time of allergen exposure (seasonal or perennial)...

more studies >>

Clinical Trials Related to Clarinex (Desloratadine)

Preference for Clarinex Tablets vs. Zyrtec Tablets in Patients With Allergies (P03180) [Completed]
This was a crossover study designed to see if patients with allergy symptoms preferred Clarinex® or Zyrtec®. Patients were randomized to take 7 days of Clarinex or Zyrtec treatment, followed by a 5 to 28-day washout period (days when no drug is given), followed by 7 days of the opposite treatment. At the end of each 7-day treatment, patients were asked questions to determine which drug, Clarinex or Zyrtec, the patient prefers more.

Preference for Clarinex Tablets vs. Zyrtec Tablets in Patients With Allergies (P03182) [Completed]
This was a crossover study designed to see if patients with allergy symptoms preferred Clarinex® or Zyrtec®. Patients were randomized to take 7 days of Clarinex or Zyrtec treatment, followed by a 5 to 28-day washout period (days when no drug is given), followed by 7 days of the opposite treatment. At the end of each 7-day treatment, patients were asked questions to determine which drug, Clarinex or Zyrtec, the patient prefers more.

Preference for Clarinex Tablets vs. Zyrtec Tablets in Patients With Allergies (P03181) [Completed]
This was a crossover study designed to see if patients with allergy symptoms preferred Clarinex® or Zyrtec®. Patients were randomized to take 7 days of Clarinex or Zyrtec treatment, followed by a 5 to 28-day washout period (days when no drug is given), followed by 7 days of the opposite treatment. At the end of each 7-day treatment, patients were asked questions to determine which drug, Clarinex or Zyrtec, the patient prefers more.

Study for the Treatment of Chronic Idiopathic Urticaria With High Doses of AERIUS (Desloratadine) (Study P04849) [Completed]
This study will investigate the effectiveness of desloratadine at doses higher (10 mg and 20 mg) than currently approved (5 mg) for the treatment of chronic idiopathic urticaria. Subjects with chronic urticaria who are currently taking a second generation antihistamine will be treated with desloratadine (5, 10, or 20 mg) for 28 days.

Preference for Clarinex Tablets vs Allegra Tablets in Patients With Seasonal Allergies (P03178) [Completed]
This was a crossover study designed to see if patients with seasonal allergy symptoms preferred Clarinex® or Allegra®. Patients were randomized to take 7 days of Clarinex or Allegra treatment, followed by a 5 to 28-day washout period (days when no drug is given), followed by 7 days of the opposite treatment. At the end of each 7-day treatment, patients were asked questions to determine which drug, Clarinex or Allegra, the patient prefers more.

more trials >>

Reports of Suspected Clarinex (Desloratadine) Side Effects

Drug Ineffective (3)Dyspnoea (3)Nasal Congestion (3)Headache (2)Myalgia (2)Dizziness (2)Drug Hypersensitivity (2)Anxiety (2)Insomnia (2)Tongue Ulceration (1)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 5 ratings/reviews, Clarinex has an overall score of 7.80. The effectiveness score is 8 and the side effect score is 9.20. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Clarinex review by 32 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Sinus Allergies/Hives
Dosage & duration:   5mg taken 1/day for the period of 3 years
Other conditions:   N/A
Other drugs taken:   N/A
  
Reported Results
Benefits:   I sometimes get hives or sinus type allergies. When I take this anti-histamine I notice that it works quickly and is very effective for hours. I never get sleepy like I do with most other over the counter anti-histamines.
Side effects:   I did not notice any side effects.
Comments:   One small pill a day is all it takes to relieve my mild to moderate sinus allergies and occassional hives.

 

Clarinex review by 57 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   allergies and asthma
Dosage & duration:   10mg taken 1 x day for the period of 3 years
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   helped relieve the allegy symptoms for a part of the day
Side effects:   sleepiness
Comments:   while this product worked for a limited time, I have found another product that works 24/7. This is an isotonic product (2 oz drink)that goes directly to the blood stream and among many other benefits dramatically reduces allergy symptoms. http://www.marketamerica.com/topproducts-13009/isotonix-opc3.htm I have no side effects from this treatment

 

Clarinex review by 49 year old male patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   allergies
Dosage & duration:   5mg taken 1/day for the period of 2 weeks
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   Did stop the sniffles and clear the nasal passages. Headaches were still a problem. However, coupling this product with aspirin provided a good solution.
Side effects:   Did cause some drowsiness. Alcohol did intensify this experience. No reported upset stomach, as is the case with some of these products.
Comments:   Treatment regimen was 1 5mg pill per day. Did not need to take with food.

See all Clarinex reviews / ratings >>

Page last updated: 2013-02-10

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