Clarinex (Desloratadine) - Summary

CLARINEX SUMMARY

CLARINEX (desloratadine) Tablets are light blue, round, film coated tablets containing 5 mg desloratadine, an antihistamine, to be administered orally.

CLARINEX is indicated for the following:

Seasonal Allergic Rhinitis: CLARINEX is indicated for the relief of the nasal and non-nasal symptoms of seasonal allergic rhinitis in patients 2 years of age and older.

Perennial Allergic Rhinitis: CLARINEX is indicated for the relief of the nasal and non-nasal symptoms of perennial allergic rhinitis in patients 6 months of age and older.

Chronic Idiopathic Urticaria: CLARINEX is indicated for the symptomatic relief of pruritus, reduction in the number of hives, and size of hives, in patients with chronic idiopathic urticaria 6 months of age and older.

See all indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Clarinex (Desloratadine)

Allergy drug tackles nasal congestion: study (Reuters)
Source: Y! Health Allergy News [2009.11.12]
Reuters - The "second generation" allergy drug desloratadine (brand name Clarinex) significantly reduces both the runny nose and congestion of seasonal and persistent allergic rhinitis, a study shows.

more news >>

Published Studies Related to Clarinex (Desloratadine)

Efficacy of desloratadine in intermittent allergic rhinitis: a GA(2)LEN study. [2009.10]
BACKGROUND: The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines proposed a classification for allergic rhinitis based on the duration of symptoms (intermittent, persistent) rather than on the time of allergen exposure (seasonal, perennial). There is no placebo-controlled, randomized clinical trial on intermittent allergic rhinitis (IAR) to date. Desloratadine (DL) is recommended for the first-line treatment of seasonal and perennial allergic rhinitis. OBJECTIVES: To assess the efficacy and safety of DL in subjects with IAR based on the ARIA classification... CONCLUSIONS: This is the first large trial to show that treatment can be effective in IAR. Desloratadine was effective and safe.

Evaluation of desloratadine on conjunctival allergen challenge-induced ocular symptoms. [2009.07]
BACKGROUND: Allergic conjunctivitis (AC) is frequently associated with allergic rhinitis (AR) and affects up to 91% of patients with AR. Desloratadine, an orally administered, non-sedating second-generation antihistamine, has proven efficacy and safety in the control of nasal and non-nasal--including ocular--symptoms of AR. This randomized-controlled trial is the first to evaluate the effects of continuous oral desloratadine treatment on ocular symptoms after conjunctival allergen challenge. OBJECTIVE: To evaluate the impact of administering oral desloratadine 5 mg daily for 7 days on ocular symptoms in conjunctival allergen-challenged subjects... CONCLUSION: Treatment with desloratadine 5 mg daily for 7 days reduced allergic ocular symptoms following allergen challenge.

Single-dose desloratadine and montelukast and allergen-induced late airway responses. [2009.06]
Montelukast and desloratadine synergistically inhibit the allergen-induced early asthmatic response...

How to prescribe antihistamines for chronic idiopathic urticaria: desloratadine daily vs PRN and quality of life. [2009.04]
BACKGROUND: Chronic idiopathic urticaria (CIU) impairs quality of life (QoL). Currently, no consensus exists regarding how second-generation H(1)-antihistamines (proven to control CIU symptoms) should be taken long-term: as daily treatment or only when symptoms return (PRN). We sought to determine which regimen improves or better maintains QoL in CIU: desloratadine (DL) daily or PRN... CONCLUSION: Continuous daily therapy with DL 5 mg is a better regimen than PRN treatment to maintain or improve QoL in subjects with CIU.

Comparison of the efficacy of levocetirizine 5 mg and desloratadine 5 mg in chronic idiopathic urticaria patients. [2009.04]
BACKGROUND: Nonsedating H(1)-antihistamines are recommended for the treatment of urticaria by the recent EAACI/GA(2)LEN/EDF guidelines. The aim of this study was to compare the efficacy, after 4 weeks of treatment, with levocetirizine 5 mg and desloratadine 5 mg, both once daily in the morning, in symptomatic chronic idiopathic urticaria (CIU) patients... CONCLUSIONS: Levocetirizine 5 mg was significantly more efficacious than desloratadine 5 mg in the treatment of CIU symptoms.

more studies >>

Clinical Trials Related to Clarinex (Desloratadine)

Fexofenadine (Allegra®) in Healthy Adults Who Have Been Identified as Slow Metabolizers for Desloratadine [Completed]
To evaluate the single-dose and steady-state pharmacokinetics of desloratadine and fexofenadine in desloratadine slow metabolizers. To evaluate the safety and tolerability of desloratadine compared to fexofenadine following single and multiple oral doses administered to desloratadine slow metabolizers.

A Study to Assess and Compare the Effects of 5 mg vs. 20 mg Desloratadine on the Development of Cold Urticaria Lesions [Completed]
The aim of this study is to compare cold urticaria lesions by thermography, volumetry and digital time lapse photography in ACU patients treated with placebo, 5 mg and 20 mg desloratadine. Hypothesis: The updosing of desloratadine (20 mg)is more effective in the treatment of ACU symptoms as compared to standard doses (5 mg desloratadine) and placebo.

Study for the Treatment of Chronic Idiopathic Urticaria With High Doses of AERIUS (Study P04849AM4) [Recruiting]
This study will investigate the effectiveness of desloratadine at doses higher (10 mg and 20 mg) than currently approved (5 mg) for the treatment of chronic idiopathic urticaria. Subjects with chronic urticaria who are currently taking a second generation antihistamine will be treated with desloratadine (5, 10, or 20 mg) for 28 days.

Study for the Treatment of Persistent Allergic Rhinitis With Desloratadine (Study P04684AM2)(COMPLETED) [Completed]
This study will investigate the effectiveness of desloratadine in treating subjects with allergic rhinitis who meet the criteria for persistent allergic rhinitis.

Study for the Treatment of Intermittent Allergic Rhinitis With Desloratadine (Study P04683AM1)(COMPLETED) [Completed]
This study will investigate the effectiveness of desloratadine in treating subjects with allergic rhinitis (AR) who meet the criteria for intermittent allergic rhinitis.

more trials >>

PATIENT REVIEWS / RATINGS / COMMENTS

Clarinex review by 32 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		Sinus Allergies/Hives
Dosage & duration:		5mg taken 1/day for the period of 3 years
Other conditions:		N/A
Other drugs taken:		N/A
		Reported Results
Benefits:		I sometimes get hives or sinus type allergies. When I take this anti-histamine I notice that it works quickly and is very effective for hours. I never get sleepy like I do with most other over the counter anti-histamines.
Side effects:		I did not notice any side effects.
Comments:		One small pill a day is all it takes to relieve my mild to moderate sinus allergies and occassional hives.

Clarinex review by 49 year old male patient
		Rating
Overall rating:
Effectiveness:		Marginally Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		allergies
Dosage & duration:		5mg taken 1/day for the period of 2 weeks
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		Did stop the sniffles and clear the nasal passages. Headaches were still a problem. However, coupling this product with aspirin provided a good solution.
Side effects:		Did cause some drowsiness. Alcohol did intensify this experience. No reported upset stomach, as is the case with some of these products.
Comments:		Treatment regimen was 1 5mg pill per day. Did not need to take with food.

Clarinex review by 49 year old male patient
		Rating
Overall rating:
Effectiveness:		Marginally Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		allergies
Dosage & duration:		5mg taken 1/day for the period of 2 weeks
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		Did stop the sniffles and clear the nasal passages. Headaches were still a problem. However, coupling this product with aspirin provided a good solution.
Side effects:		Did cause some drowsiness. Alcohol did intensify this experience. No reported upset stomach, as is the case with some of these products.
Comments:		Treatment regimen was 1 5mg pill per day. Did not need to take with food.