Clarinex (Desloratadine) - Summary

CLARINEX SUMMARY

CLARINEX (desloratadine) Tablets are light blue, round, film coated tablets containing 5 mg desloratadine, an antihistamine, to be administered orally.

CLARINEX is indicated for the following:

Seasonal Allergic Rhinitis: CLARINEX is indicated for the relief of the nasal and non-nasal symptoms of seasonal allergic rhinitis in patients 2 years of age and older.

Perennial Allergic Rhinitis: CLARINEX is indicated for the relief of the nasal and non-nasal symptoms of perennial allergic rhinitis in patients 6 months of age and older.

Chronic Idiopathic Urticaria: CLARINEX is indicated for the symptomatic relief of pruritus, reduction in the number of hives, and size of hives, in patients with chronic idiopathic urticaria 6 months of age and older.

See all Clarinex indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Clarinex (Desloratadine)

Petasol butenoate complex (Ze 339) relieves allergic rhinitis-induced nasal obstruction more effectively than desloratadine. [2011.06]
BACKGROUND: Allergic rhinitis symptoms of itching, sneezing, rhinorrhea, and nasal obstruction significantly decrease patients' quality of life. Compared with histamine and leukotriene receptor antagonists, the petasol butenoate complex Ze 339 displays pharmacologically distinct properties. In vitro it inhibits the biosynthesis of leukotrienes and mediator release from activated eosinophils. OBJECTIVE: This study aimed to assess the efficacy and mode of action of Ze 339, desloratadine, and placebo on allergic rhinitis symptoms, nasal airflow, and local mediator levels after unilateral nasal allergen provocation... CONCLUSION: When compared with desloratadine and placebo, Ze 339 shows better efficacy in relieving nasal obstruction symptoms and inhibiting critical components of the chemokine network and as such represents a novel symptomatic and possible prophylactic treatment for allergic rhinitis. Copyright (c) 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

Use of montelukast alone or in combination with desloratadine or levocetirizine in patients with persistent allergic rhinitis. [2011.01]
BACKGROUND: We assessed the course of treatment in patients with persistent allergic rhinitis (AR) treated with montelukast, levocetirizine, or desloratadine alone or combinations of antihistamine and montelukast... CONCLUSION: Montelukast alone or in combination with antihistamines gave a gradual increase in nasal symptom improvement within 6 weeks of treatment in patients with persistent AR.

Use of montelukast alone or in combination with desloratadine or levocetirizine in patients with persistent allergic rhinitis. [2011]
alone or combinations of antihistamine and montelukast... CONCLUSION: Montelukast alone or in combination with antihistamines gave a

Petasol butenoate complex (Ze 339) relieves allergic rhinitis-induced nasal obstruction more effectively than desloratadine. [2011]
local mediator levels after unilateral nasal allergen provocation... CONCLUSION: When compared with desloratadine and placebo, Ze 339 shows better

Efficacy of Desloratadine in Persistent Allergic Rhinitis - A GALEN Study. [2010.06.18]
Background: The ARIA (Allergic Rhinitis and its Impact on Asthma) guidelines proposed a classification for allergic rhinitis based on the duration of symptoms (intermittent or persistent) rather than on the time of allergen exposure (seasonal or perennial)...

more studies >>

Clinical Trials Related to Clarinex (Desloratadine)

Fexofenadine (Allegra®) in Healthy Adults Who Have Been Identified as Slow Metabolizers for Desloratadine [Completed]
To evaluate the single-dose and steady-state pharmacokinetics of desloratadine and fexofenadine in desloratadine slow metabolizers. To evaluate the safety and tolerability of desloratadine compared to fexofenadine following single and multiple oral doses administered to desloratadine slow metabolizers.

A Study to Assess and Compare the Effects of 5 mg vs. 20 mg Desloratadine on the Development of Cold Urticaria Lesions [Completed]
The aim of this study is to compare cold urticaria lesions by thermography, volumetry and digital time lapse photography in ACU patients treated with placebo, 5 mg and 20 mg desloratadine. Hypothesis: The updosing of desloratadine (20 mg)is more effective in the treatment of ACU symptoms as compared to standard doses (5 mg desloratadine) and placebo.

Study for the Treatment of Chronic Idiopathic Urticaria With High Doses of AERIUS (Study P04849AM4) [Recruiting]
This study will investigate the effectiveness of desloratadine at doses higher (10 mg and 20 mg) than currently approved (5 mg) for the treatment of chronic idiopathic urticaria. Subjects with chronic urticaria who are currently taking a second generation antihistamine will be treated with desloratadine (5, 10, or 20 mg) for 28 days.

Study for the Treatment of Persistent Allergic Rhinitis With Desloratadine (Study P04684AM2)(COMPLETED) [Completed]
This study will investigate the effectiveness of desloratadine in treating subjects with allergic rhinitis who meet the criteria for persistent allergic rhinitis.

Study for the Treatment of Intermittent Allergic Rhinitis With Desloratadine (Study P04683AM1)(COMPLETED) [Completed]
This study will investigate the effectiveness of desloratadine in treating subjects with allergic rhinitis (AR) who meet the criteria for intermittent allergic rhinitis.

more trials >>

Reports of Suspected Clarinex (Desloratadine) Side Effects

Drug Ineffective (3),  Dyspnoea (3),  Nasal Congestion (3),  Headache (2),  Myalgia (2),  Dizziness (2),  Drug Hypersensitivity (2),  Anxiety (2),  Insomnia (2),  Tongue Ulceration (1), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Clarinex review by 32 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		Sinus Allergies/Hives
Dosage & duration:		5mg taken 1/day for the period of 3 years
Other conditions:		N/A
Other drugs taken:		N/A
		Reported Results
Benefits:		I sometimes get hives or sinus type allergies. When I take this anti-histamine I notice that it works quickly and is very effective for hours. I never get sleepy like I do with most other over the counter anti-histamines.
Side effects:		I did not notice any side effects.
Comments:		One small pill a day is all it takes to relieve my mild to moderate sinus allergies and occassional hives.

Clarinex review by 57 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		allergies and asthma
Dosage & duration:		10mg taken 1 x day for the period of 3 years
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		helped relieve the allegy symptoms for a part of the day
Side effects:		sleepiness
Comments:		while this product worked for a limited time, I have found another product that works 24/7. This is an isotonic product (2 oz drink)that goes directly to the blood stream and among many other benefits dramatically reduces allergy symptoms. http://www.marketamerica.com/topproducts-13009/isotonix-opc3.htm I have no side effects from this treatment

Clarinex review by 49 year old male patient
		Rating
Overall rating:
Effectiveness:		Marginally Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		allergies
Dosage & duration:		5mg taken 1/day for the period of 2 weeks
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		Did stop the sniffles and clear the nasal passages. Headaches were still a problem. However, coupling this product with aspirin provided a good solution.
Side effects:		Did cause some drowsiness. Alcohol did intensify this experience. No reported upset stomach, as is the case with some of these products.
Comments:		Treatment regimen was 1 5mg pill per day. Did not need to take with food.