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Cilostazol (Cilostazol) - Summary

 

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CONTRAINDICATION
Cilostazol and several of its metabolites are inhibitors of phosphodiesterase III. Several drugs with this pharmacologic effect have caused decreased survival compared to placebo in patients with class III-IV congestive heart failure. Cilostazol is contraindicated in patients with congestive heart failure of any severity.

 

CILOSTAZOL SUMMARY

Cilostazol Tablets
50 mg and 100 mg
Rx only

Cilostazol is a quinolinone derivative that inhibits cellular phosphodiesterase (morespecific for phosphodiesterase III).

Cilostazol is indicated for the reduction of symptoms of intermittent claudication, as indicated by an increased walking distance.

CILOSTAZOL NEWS HIGHLIGHTS

Published Studies Related to Cilostazol

Protective Effects of Cilostazol against Transient Focal Cerebral ischemia and Chronic Cerebral Hypoperfusion Injury. [2008.06]

Long-term safety of cilostazol in patients with peripheral artery disease: the CASTLE study (Cilostazol: A Study in Long-term Effects). [2008.02]

Effects of triple antiplatelet therapy (aspirin, clopidogrel, and cilostazol) on platelet aggregation and P-selectin expression in patients undergoing coronary artery stent implantation. [2007.08.15]

Cilostazol reduces inflammatory burden and oxidative stress in hypertensive type 2 diabetes mellitus patients. [2007.08]

Cilostazol reduces inflammatory burden and oxidative stress in hypertensive type 2 diabetes mellitus patients. [2007.05.03]

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Clinical Trials Related to Cilostazol

Fasting Study of Cilostazol Tablets 100 mg and PletalŪ Tablets 100 mg [Completed]

Post-Marketing Study of Cilostazol (Cilostazol Stroke Prevention Study 2) [Active, not recruiting]

Cilostazol in Acute Ischemic Stroke Treatment (CAIST) [Active, not recruiting]

Efficacy and Safety Study of Cilostazol to Prevent Reoccurrence of Stroke [Completed]

Study to Assess the Effect of Pharmacokinetics/Pharmacodynamics (PK/PD) Interaction After co-Administration of Cilostazol With Ginkgo Biloba or Placebo [Active, not recruiting]

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Page last updated: 2008-06-22

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